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Biological investigations of medicinal plants of heliotropium indicum indigenous to Bangladesh

Journal of Coastal Life Medicine 2016年第11期4卷 874-878页

作者： Karim Samira Kawsar Md Farhina Rahman Laboni Azima Sultana Julie Uddin Jalal Zubair Khalid Labu Department of Pharmacy World University of Bangladesh(WUB)151/8 Green RoadDhakaBangladesh

Objective:To investigate the clot lysis,antimicrobic and membrane stabilizing potentials of ethanolic extractives of the leaves of heliotropium indicum(***).Methods:Crude ethanolic extracts of *** leaves were partitioned successively using solvents of different polarity and subjected to determine qualitatively and quantitatively for the presence of different bioactive constitutes and fractions which were assessed for their possible clot lysis,antimicrobic,and membrane stabilizing activities as compared with the known ***:For the thrombolytic activity,the petroleum ether soluble fraction showed the highest percent of clot lysis(35.4%)among all fractions,while streptokinase and water resulted in 65.15%and 3.77%clot lysis,*** respect to the membrane stabilizing activity,carbon tetrachloride soluble fraction of *** profoundly interdicted the hemolysis of erythrocytes brought about by osmotic induction(39.24%)or by heat(40.20%).The other fractions exhibited less significant membrane stabilizing *** contrast,acetylsalicylic acid resulted in 72.25%±0.30%inhibition of osmotically induced hemolysis and showed a lower level of protection of heat induced hemolysis(42.56%).Crude ethanolic extracts were moderately sensitive against known pathogenic *** pharmacological activities of *** are due to the presence of bioactive compounds,we detected and quantified the presence of significant levels of flavonoid and tannin ***:The outcomes of this research show that the leaves of *** have the potential to be used as a remedy for thrombosis,inflammatory diseases and against few important bacterial pathogens.

关键词： heliotropium indicum Thrombolytic Membrane stabilizing Antimicrobial activity

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