Biological investigations of medicinal plants of Heliotropium indicum indigenous to Bangladesh

作     者：Karim Samira Kawsar Md Farhina Rahman Laboni Azima Sultana Julie Uddin Jalal Zubair Khalid Labu 

作者机构：Department of PharmacyWorld University of Bangladesh(WUB)151/8 Green RoadDhakaBangladesh 

出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)

年 卷 期：2016年第4卷第11期

页      面：874-878页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the assistance of research section of Department of Pharmacy World University of Bangladesh(Grant No.WUBPS#04567) 

主　　题：Heliotropium indicum Thrombolytic Membrane stabilizing Antimicrobial activity 

摘      要：Objective:To investigate the clot lysis,antimicrobic and membrane stabilizing potentials of ethanolic extractives of the leaves of Heliotropium indicum(***).Methods:Crude ethanolic extracts of *** leaves were partitioned successively using solvents of different polarity and subjected to determine qualitatively and quantitatively for the presence of different bioactive constitutes and fractions which were assessed for their possible clot lysis,antimicrobic,and membrane stabilizing activities as compared with the known ***:For the thrombolytic activity,the petroleum ether soluble fraction showed the highest percent of clot lysis(35.4%)among all fractions,while streptokinase and water resulted in 65.15%and 3.77%clot lysis,*** respect to the membrane stabilizing activity,carbon tetrachloride soluble fraction of *** profoundly interdicted the hemolysis of erythrocytes brought about by osmotic induction(39.24%)or by heat(40.20%).The other fractions exhibited less significant membrane stabilizing *** contrast,acetylsalicylic acid resulted in 72.25%±0.30%inhibition of osmotically induced hemolysis and showed a lower level of protection of heat induced hemolysis(42.56%).Crude ethanolic extracts were moderately sensitive against known pathogenic *** pharmacological activities of *** are due to the presence of bioactive compounds,we detected and quantified the presence of significant levels of flavonoid and tannin ***:The outcomes of this research show that the leaves of *** have the potential to be used as a remedy for thrombosis,inflammatory diseases and against few important bacterial pathogens.