检索结果-南通市图书馆

Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

Acta Pharmaceutica Sinica B 2024年第9期14卷 3983-4000页

作者： Ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying Zhao Xiaoming Zou Fudi Wang Yuan Ping Qiang Ma The Seventh Affiliated Hospital Southern Medical UniversityFoshan 528244China Department of Biopharmaceutics School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China Medical Critical Care Medicine General Hospital of Southern Theatre Command of PLAGuangzhou 510000China Guangdong Branch Center National Clinical Research Center for Geriatric Diseases(Chinese PLA General Hospital)Guangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaip1Macao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402China Department of General Surgery Nanfang Hospitalthe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510000China The Fourth Affiliated Hospital the First Affiliated HospitalSchool of Public HealthInstitute of Translational MedicineCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhou 310000China The First Affiliated Hospital the Second Affiliated HospitalBasic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 421200China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310000China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 310000China Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China

With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver *** other forms of liver injury,heat strokeinduced damage is characterized by heat cytotoxicity and heightened inflammation,directly contributing to elevated mortality *** clinical assessments have identified elevated bilirubin levels as indicative of Kupffer cell dysfunction,their specific correlation with heat stroke liver injury remains *** hypothesis proposes the involvement of Kupffer cell ferroptosis during heat stroke,initiating IL-1bmediated *** single-cell RNA sequencing of murine macrophages,a distinct and highly susceptible Kupffer cell subtype,Clec4Ft/CD206t,emerged,with heme oxygenase 1(HMOX-1)playing a pivotal ***,heat-induced HMOX-1,regulated by early growth response factor 1,mediated ferroptosis in Kupffer cells,specifically in the Clec4F t/CD206 t subtype(KC2),activating phosphatidylinositol 4-kinase beta and promoting PI4P *** cascade triggered NLRP3 inflammasome activation and maturation of *** findings underscore the critical role of targeted therapy against HMOX-1 in ferroptosis within Kupffer cells,particularly in Clec4F t/CD206 t *** an approach has the potential to mitigate inflammation and alleviate acute liver injury in the context of heat stroke,offering a promising avenue for future therapeutic interventions.

关键词： heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

heat stroke alters hippocampal and cerebellar transmitter metabonomics

引用

World Journal of Emergency Medicine 2023年第4期14卷 287-293页

作者： Guoxin He Ancong Xu Xichong Yu Fan Huang Lei Su The First School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine the Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhou 325035China

BACKGROUND:The mechanisms underlying heat stroke(HS)-induced hippocampal injury remain *** study aimed to evaluate the HS-induced metabonomics of hippocampal and cerebellar ***:The HS model was established with male Sprague-Dawley rats subjected to heat exposure of up to 42℃ at a humidity of(55.0±5.0)%.The hippocampal and cerebellar transmitters and metabolites of rats were tested via ultra-high-performance liquid chromatography–mass spectrometry(UPLC-MS/MS).The primary transmitters and metabolites were identified by principal component analysis(PCA)and orthogonal partial least square-discriminant analysis(OPLS-DA).The major metabolic pathways for HS were selected after *** brain injury was evaluated by histological ***:HS induced hippocampal and cerebellar injuries in *** upregulated the protein levels of hippocampal glutamate,glutamine,gamma-aminobutyric acid,L-tryptophan(Trp),5-hydroxy-indoleacetic acid,and kynurenine;however,it downregulated asparagine,tryptamine,5-hydroxytryptophan,melatonin,3,4-dihydroxyphenylalanine(L-DOPA),and vanillylmandelic *** also sharply elevated the protein levels of cerebellar methionine and Trp,and decreased the levels of serotonin,L-alanine,L-asparagine,L-aspartate,cysteine,norepinephrine,spermine,spermidine,and *** glutamate,monoamine transmitters,cerebellar aspartate acid,and catecholamine transmitters’metabolic pathways were identified as the main metablic pathways in ***:The hippocampus and cerebellum were injured in rats with HS,possibly induced the disorder of hippocampal glutamate and serotonin metabolism,cerebellar aspartate acid and catecholamine transmitter metabolism,and related metabolic pathways.

关键词： heat stroke Transmitters Rat Hippocampus Cerebellum Metabonomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats

引用

Journal of Traditional Chinese Medicine 2013年第2期33卷 243-249页

作者： Yi Chen Huasheng Tong Xingqin Zhang Liqun Tang Zhiguo Pan Zhifeng Liu Pengkai Duan Lei Su Guangzhou University of Chinese Medicine Department of ICU General Hospital of Guangzhou Military CommandKey Laboratory of Tropical Zone Trauma Care andTissue Repair of PLA

OBJECTIVE： To evaluate the effects of Xuebijing （XBJ） injection in heat stroke （HS） rats and to inves- tigate the mechanisms underlying these effects. METHODS： Sixty anesthetized rats were random- ized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ （XBJ group） or phosphate buffered saline （HS and Sham groups） per kg body weight. HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber （ambient temperature 40℃：, humidity 60% ）. Rectal temperature, aterial pressure, and heart rate were monitored and recorded. Time to HS onset and survival were determined, and serum concentrations of tumor necrosis factor （TNF）-α, in-terleukin （IL）-1β, IL-6, alanine-aminotransferase （ALT）, and aspartate-aminotransferase （AST） were measured. Hepatic tissue was harvested for patho- logical examination and electron microscopic ex- amination. Kupffer cells （KCs） were separated from liver at HS initiation, and the concentrations of se- creted TNF-α, IL-1β3 and IL-6 were measured. RESULTS： Time to HS onset and survival were signif- icantly longer in the XBJ than in the HS group. Moreover, the concentrations of TNF-α, IL-1β, IL-6, ALT and AST were lower and liver injury was milder in the XBJ than in the HS group. heat-stress in- duced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α, IL-1β and IL-6 se- creted by KCs were lower in the XBJ than in the HS group. CONCLUSION： XBJ can alleviate HS-induced sys- temic inflammatory response syndrome and liver injury in rats, and improve outcomes. These protec- tive effects may be due to the ability of XBJ to inhib- it cytokine secretion by KCs.

关键词： heat stroke Kupffer cells Systemic in-flammatory response syndrome Xuebijing Liver in-jury Inflammatory cytokines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interpretations and comments for expert consensus on the diagnosis and treatment of heat stroke in China

引用

Military Medical Research 2020年第3期7卷 371-372页

作者： Shu-Yuan Liu Qian Wang Yun-Peng Lou Yan Gao Bo Ning Qing Song Hai-Ling Li Medical School of Chinese PLA No.28 of Fuxing RoadBeijing 100853China Emergency Department Sixth Medical CenterChinese PLA General HospitalNo.6 of Fucheng RoadBeijing 100048China Emergency Department Third Medical CenterChinese PLA General HospitalNo.69 of Yongding RoadBeijing 100039China Department of Intensive Care Unit No.971 Hospital of the People’s Liberation Army NavyNo.22 Minjiang RoadQingdao 266071China Emergency Department General Hospital of Northern Theater Command of Chinese PLANo.83 of Wenhua RoadShenyang 110016China Department of Intensive Care Unit Air Force Medical Center of ChinaNo.30 of Fucheng RoadBeijing 100142China

heat stroke is the most severe type of heat illness,it is often accompanied by severe multiorgan damage and has a high fatality *** January 2020,based on new research evidence and the experiences of Chinese experts in heat stroke,the Expert Group of heat stroke Prevention and Treatment of the Chinese People’s Liberation Army(PLA)and the Professional Committee of Critical Care Medicine of the Chinese PLA jointly issued a new Expert Consensus on the Diagnosis and Treatment of heat stroke in *** article aims to interpret and supplement the major updates to the new consensus.

关键词： heat stroke Definition Diagnosis Treatment Targeted temperature management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?

引用

World Journal of Gastroenterology 2007年第2期13卷 306-309页

作者： Kilian Weigand Carina Riediger Wolfgang Stremmel Christa Flechtenmacher Jens Encke Department of Gastroenterology and Hepatology Medicine Ⅳ University of Heidelberg 69120 Heidelberg Germany Department of Pathology University of Heidelberg 69120 Heidelberg Germany

While cardiopulmonary symptoms are common in patients undergoing dassical or, due to physical exercise, exertional heat stroke, the failure of other organs is a rarely described phenomenon. Here we present two cases of acute hepatic failure, one due to classic heat shock, while the other occurred while the patient was doing a marathon-type running. Both cases presented with very high transaminases and significantly elevated international normalized ratio （INR）. No other causes for liver failure could be identified but physical exhaustion and hyperthermia.

关键词： heat stroke Acute hepatic failure heat shock Liver failure Hyperthermia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and evaluation of a predictive nomogram for survival in heat stroke patients: a retrospective cohort study

引用

World Journal of Emergency Medicine 2022年第5期13卷 355-360页

作者： Fei Shao Xian Shi Shu-hua Huo Qing-yu Liu Ji-xue Shi Jian Kang Ping Gong Sheng-tao Yan Guo-xing Wang Li-jie Qin Fei Wang Ke Feng Feng-ying Chen Yong-jie Yin Tao Ma Yan Li Yang Wu Hao Cui Chang-xiao Yu Song Yang Wei Gan Sai Wang Liu-ye-zi Du Ming-chen Zhao Zi-ren Tang Shen Zhao Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Medicine Hebei Yanda HospitalLangfang 065201China Department of Emergency Medicine Beijing Huairou HospitalBeijing 101400China Department of Emergency Medicine the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Emergency Medicine the Second Affi liated Hospital of Shandong First Medical UniversityTai’an 271000China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China Department of Emergency Medicine Henan Provincial People’s HospitalZhengzhou 450003China Department of Emergency Medicine Beijing Tsinghua Changung HospitalBeijing 102218China Department of Emergency Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004China Department of Emergency Medicine the Affi liated Hospital of Inner Mongolia Medical UniversityHohhot 010050China Department of Emergency Medicine the Second Hospital of Jilin UniversityChangchun 130021China Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Department of Emergency Medicine the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Big Data Research Goodwill Hessian Health Technology Co.Ltd.Beijing 100085China School of Public Health Peking UniversityBeijing 100083China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020China Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND:This study aimed to establish an eff ective nomogram to predict the survival of heat stroke(HS)based on risk ***:This was a retrospective,observational multicenter cohort *** analyzed patients diagnosed with HS,who were treated between May 1 and September 30,2018 at 15 tertiary hospitals from 11 cities in Northern ***:Among the 175 patients,32 patients(18.29%)died before hospital *** the univariate analysis,mechanical ventilation,initial mean arterial pressure<70 mmHg,maximum heart rate,lab results on day 1(white blood cell count,alanine aminotransferase,creatinine),and Glasgow admission prediction score were included in multivariate *** Cox regression showed that invasive ventilation,initial mean arterial pressure<70 mmHg(1 mmHg=0.133 kPa),and Glasgow admission prediction score were independent risk factors for *** nomogram was established for predicting 7-d and 14-d survival in the training *** nomogram exhibited a concordance index(C-index)of 0.880(95%confidence interval[95%CI]0.831-0.930)by bootstrapping validation(B=1,000).Furthermore,the nomogram performed better when predicting 14-d survival,compared to 7-d *** prognostic index cut-off value was set at 2.085,according to the operating characteristic curve for overall survival *** model showed good calibration ability in the internal and external validation ***:A novel nomogram,integrated with prognostic factors,was proposed;it was highly predictive of the survival in HS patients.

关键词： heat stroke Nomogram Survival Prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research progress of heat stroke during 1989–2019: A bibliometric analysis

引用

Military Medical Research 2021年第3期8卷 384-394页

作者： De-Meng Xia Xu-Ren Wang Pan-Yu Zhou Tian-Le Ou Lei Su Shuo-Gui Xu Department of Emergency Changhai Hospitalthe Naval Medical UniversityShanghai 200433China Nursing College The Naval Medical UniversityShanghai 200433China Department of Clinical Medicine The Naval Medical UniversityShanghai 200433China Department of Intensive Care Unit General Hospital of Southern Theater CommandGuangzhou 510010China

Background: heat stroke(HS) is an acute physical disorder that is associated with a high risk of organ dysfunction and even death. HS patients are usually treated symptomatically and conservatively;however, there remains a lack of specific and effective drugs in clinical practice. An analysis of publication contributions from institutions, journals and authors in different countries/regions was used to study research progress and trends regarding ***: We extracted all relevant publications on HS between 1989 and 2019 from Web of Science. Using the Statistical Package for Social Science(SPSS, version 24) and the software GraphPad Prism 8, graphs were generated and statistical analyses were performed, while VOSviewer software was employed to visualize the research trends in HS from the perspectives of co-occurring ***: As of April 14, 2020, we identified 1443 publications with a citation frequency of 5216. The United States accounted for the largest number of publications(36.2%) and the highest number of citations(14,410), as well as the highest H-index at 74. Although the sum of publications from China ranked second, there was a contradiction between the quantity and quality of publications. Furthermore, Medicine & Science in Sports & Exercise published the most papers related to HS, with Lin MT publishing the most papers in this field(112), while the review by Knochel JP received the highest citation frequency at 969. The keyword heat-stress appeared most recently, with an average appearing year of 2015.5. In the clinical research cluster, exertional heat-stroke was determined to be the hotspot, while ambient-temperature and heat waves were the new trends in the epidemiological research ***: Corresponding to this important field, while the contributions of the publications from the United States were significant, the mismatch between the quantity and quality of publications from China must be examined. Moreover, it is hypothesized

关键词： heat stroke Publications Citation frequency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Full neurological recovery from severe nonexertional heat stroke with multiple organ dysfunction:A case report

引用

World Journal of Clinical Cases 2023年第10期11卷 2355-2362页

作者： Fang Du Jun-Wei Zheng Yan-Bo Zhao Kai Yang Hu-Nian Li Emergency and Critical Care Center Hubei University of MedicineRenmin HospitalShiyan 442000Hubei ProvinceChina Department of Anesthesiology Hubei University of MedicineRenmin HospitalShiyan 442000Hubei ProvinceChina

BACKGROUND We report a rare case of full neurological recovery from severe nonexertional heat stroke in a 67-year-old woman with an initial Glasgow Coma Scale of *** report raises awareness among doctors that when heatstroke is diagnosed,comprehensive treatment should be implemented as soon as ***,targeted temperature management,combination therapy with hemodialysis and hemoperfusion,and hyperbaric oxygen therapy may alleviate multiorgan failure and prevent neurological sequelae caused by *** SUMMARY A previously healthy 67-year-old woman with an initial Glasgow Coma Scale of 3 was found lying prone on the road at noon on a summer *** tests revealed multiorgan *** soon as heatstroke was diagnosed,comprehensive treatment was *** hospital Day 3,the patient was *** initial Sequential Organ Failure Assessment score at hospitalization was 14 and decreased to 2 on hospital Day *** the seventh day following hospital admission,as the patient’s general condition improved,the levels of laboratory test findings decreased ***,the patient gradually recovered with no other neurological symptoms(the Glasgow Coma Scale at discharge was 15,and her ability to walk independently was restored).CONCLUSION This case demonstrated that targeted temperature management,combination therapy with hemodialysis and hemoperfusion,and hyperbaric oxygen therapy may alleviate multiorgan failure and prevent neurological sequelae caused by heatstroke.

关键词： heat stroke Multiple organ failure Neurological Recovery Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A bibliometric analysis of exertional heat stroke research in Web of Science

引用

Journal of Medical Colleges of PLA(China) 2016年第4期31卷 188-193页

作者： Zhi Mao Chao Liu Shuo Chen Zheng-Guo Zhu Hong-Jun Kang Fei-Hu Zhou Department of Critical Care Medicine Chinese PLA General Hospital Department of Medical Information Chinese PLA General Hospital Department of Orthopedics Chinese PLA General Hospital

Background:Exertional heat stroke is a fatal condition and remains a health *** paper evaluates the publication trend regarding exertional heat stroke research between 1996 and 2015 using a bibliometric ***:Articles regarding exertional heat stroke research published between 1996 and December 2015 were searched for in the SCI-EXPANDED database of Web of *** search results were analyzed with regard to publication year;publication quantity regarding countries/regions;authors;citation frequency;and journal *** Space(v3.6) was used for a document co-citation visualization ***:In total,289 publications on heat stroke were *** selection,209 original articles conducted across 28 countries/regions and published in 83 journals were included in the *** USA,Isreal,and France were the most common locations for exertional heat stroke *** Cite Space visualization cluster analysis showed that exertional heat stroke-related mortality and protective measures were constant concerns of ***:Research related to exertional heat stroke has been continuous *** is still the leading country in this field.

关键词： heat stroke Bibliometric analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Association Study of CASQ1 Gene Polymorphisms and heat stroke

引用

Genomics, Proteomics & Bioinformatics 2014年第3期12卷 127-132页

作者： Ying Li Yu Wang Lin Ma Department of Radiology Chinese PLA Medical School Department of Health Medicine Beijing Electric Power Hospital

Although molecular mechanisms of heat stroke under physiological and pathological conditions have not yet been elucidated, a novel disease-associated gene encoding a calcium-binding protein, calsequestrin-1 （CASQ1）, was suggested relevant based on results from a transgenic murine model. Here, we show the association between single nucleotide polymorphisms （SNPs） of CASQ1 and physiological parameters for heat stroke from a study involving 150 patients. Pooled DNA from heat stroke patients were subjected to sequencing and 3 SNPs were identified. Genotypes were assigned for all patients according to g. 175A 〉 G, one SNP which leads to a nonsynonymous sub- stitution （N59D） in the first exon of human CASQ1 gene. We analyzed the genotypic data with a linear model based on significance scores between SNP （175A 〉 G） and heat stroke parameters. As a result, we found a significant association between SNP A175G and heat stroke （P ~ 0.05）. Further bioinformatics analysis of the 1-Mb flanking sequence revealed the presence of two genes that encode DDB1 and CUL4 associated factor 8 （DCAF8）, and peroxisomal biogenesis factor 19 （PEX19）, respectively, which might be functionally related to CASQ1. Our results showed that the blood calcium of patients with allele D increased significantly, compared to patients with allele N （P 〈 0.05）, which may result from the decreased calcium in muscle, suggesting that N59D in CASQ1 might account for the dysfunction of CASQ1 in calcium regulation during heat stroke.

关键词： CASQ1 heat stroke Single nucleotidepolymorphism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：