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The impact of hearing impairment and noise-induced hearing injury on quality of life in the active-duty military population:challenges to the study of this issue

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Journal of Medical Colleges of PLA(China) 2016年第3期31卷 153-161页

作者： Hasanat Alamgir Caryn A.Turner Nicole J.Wong Sharon P.Cooper Jose A.Betancourt James Henry Andrew J.Senchak Tanisha L.Hammill Mark D.Packer Deptartment of Health Policy and Management School of Health Sciences and PracticeNew York Medical CollegeValhallaNY 10595USA School of Public Health The University of Texas Health Science Center at Houston7411 John Smith Drive Suite 1100 San AntonioTX 78229USA National Center for Rehabilitative Auditory Research 3710 SW US Veteran Hospital RoadPortlandOR 87239USA Walter Reed National Military Medical Center 8901 Wisconsin AveBethesdaMD 20814USA Department of Defense hearing Center of Excellence 59MDW/SG02O2200 Bergqiust Drive Suite 1JBSA LacklandTX 78236USA.

The objectives of this review were to 1)summarize the available evidence on the impact of hearing loss on quality of life(QOL)among ***-duty service members,2)describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life,3)examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members,and 4)provide recommendations for future studies that seek to quantify the impact of hearing loss in this *** is a lack of literature that addresses the intersection of hearing impairment,the military population,and quality of life *** audiological research,*** personnel offer a unique research population,as they are exposed to noise levels and blast environments that are highly unusual in civilian work settings and can serve as a model population for studying the impact on QOL associated with these *** review recommends conducting a study on the active-duty service member population using a measurement instrument suitable for determining decreases in QOL specifically due to hearing loss.

关键词： Quality of life(QOL) hearing impairment Noise-induced hearing injury hearing loss Tinnitus hearing impairment and noise-induced hearing injury(HINIHI) Military Service members

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Single nucleotide polymorphisms and haplotypes analysis of DFNB1 locus in Chinese sporadic hearing impairment population

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Chinese Medical Journal 2009年第13期122卷 1549-1553页

作者： CHENG Hong-bo CHEN Zhi-bin WEI Qing-jun LU Ya-jie XING Guang-qian CAO Xin Department of Biotechnology Nanjing Medical University Nanjing Jiangsu 210029 China Department of Otorhinolaryngology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China

Background The DFNB1 locus, which contains the gap junction beta-2 （GJB2） and gap junction beta-6 （GJB6） genes, plays a key role in the nonsyndromic and sporadic hearing impairment. Mutations of DFNB1 result in autosomaJ recessive nonsyndromic hearing impairment （ARNSHI）. Previous researches have identified mutations in GJB2 and GJB6, but single nucleotide polymorphisms （SNPs） of DFNB1 locus have not been studied. So we chose five SNPs to evaluate whether there is difference between deafness people and normal-hearing people in Han Chinese. Methods Five SNPs in the DFNB1 region were examined using a case-control association study between cases with sporadic hearing impairment and controls with normal hearing. The HWEsoft and SHEsis softwares were used to analyze the results. Results Single-locus association analysis showed a positive association for three SNPs： rs9315400, rs2274084 and 235delC. When we compared the distributions of the haplotypes, we also found significant differences between cases and controls in the haplotype combination of rs2274084 and rs2274083 （Х^2=12.978, df=3, global P=0.004719）. Conclusions The haplotypes composed of rs2274084 and rs2274083 suggested that C-C may be a risk haplotype for the sporadic hearing impairment while T-T may be protective against hearing impairment. From that point of view, we can conclude that the SNPs of DFNB1 locus also plays an important role in sporadic hearing impairment cases.

关键词： DFNB1 locus single nucleotide polymorphisms haplotype hearing impairment

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Does hearing impairment Have an Impact on the Children’s Education in Casamance, South of Senegal?

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第4期10卷 313-319页

作者： Ndadi Tchiengang K. Junie Evelyne Siga Diom Bay Karim Diallo ENT and CCF Department Peace Hospital Ziguinchor Senegal ENT and CCF Department Albert Royer Children’s Hospital Dakar Senegal

Goal: To determine the impact of deafness on the schooling of children in Casamance and the factors that characterize these repercussions. Patients and Methods: This was a retrospective, cross-sectional and multicenter study carried out in the ENT departments of the peace and regional hospitals of Ziguinchor over a period of 7 years from January 1, 2012 to December 31, 2019. It included hearing impaired children aged 1 to 18. Results: 178 hearing impaired children were collected during the study period. One hundred and forty-seven children were in school (82, 58%), the majority (85.03%) attending formal schools. Fifty-seven children had a speech disorder (32.02%). The average age of screening for deafness was 9 years. Deafness was mild in 53 patients. Thirteen patients had severe deafness. Two patients presented with cophosis. Conclusion: Our study shows that deafness does indeed have an impact on a child’s education in Casamance, but this impact is hardly taken into account.

关键词： Repercussion hearing impairment Child Casamance

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Influence of pump noise on the health of fish in a large pumping station

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Journal of Hydrodynamics 2022年第3期34卷 522-531页

作者： Fan Zhang Lu-feng Zhu Xiao-tao Shi Ke Chen Desmond Appiah Shou-qi Yuan Jin-feng Zhang National Research Center of Pumps Jiangsu UniversityZhenjiang212013China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang443002China

The axial flow pump,characteristic of a large flow,is widely used in pumping stations of hydraulic ***,the internal noise of the axial-flow pump of a high sound pressure level is notable,with a great influence on the fishing *** present,the studies of the impact of the noise on fish are mainly focused on the explosion,the offshore wind power plant,the ship and other fields,with little attention on the noise generated by the pumping *** paper applies the combination of the computational fluid dynamics and the Actran to study the sound pressure level distribution in the high-noise area inside the axial-flow pump and the noise distribution in the downstream areas of the pumping *** comparisons are made of the hearing threshold and the hearing damage threshold of fish,and it is revealed that the noise inside the axial-flow pump exceeds the hearing damage threshold of fish,which could lead to the hearing damage of over-pumped ***,the noises emitted from the pumping station to the downstream are beyond the fish hearing threshold and will also have a significant impact on the fish around the pumping *** study can provide a reference for studying the impact of the noise generated by various large-scale water transfer projects on fish.

关键词： Fish numerical analysis axial flow pump ACTRAN hearing impairment

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Acceptable noise level as a deciding factor for prescribing hearing aids for older adults with cochlear hearing loss-A scoping review

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Journal of Otology 2015年第3期10卷 93-98页

作者： Hemanth Narayan Shetty Swathi Subbanna All India Institute of Speech and hearing

Older adults often find it difficult to perceive speech, especially in noisy conditions. Though hearing aid is one of the rehabilitative devices available to older adults to alleviate hearing loss, some of them may experience annoyance through hearing aid and hence reject it, may be due to circuitry noise and/or background noise. Acceptable noise level is a direct behavioural measure to estimate the extent of how much a person is able to put up with noise while simultaneously listening to speech. Acceptable noise level is a central auditory measure and it is not influenced by age, gender, presentation level or speaker. Using this measure, we can quantify the annoyance level experienced by an individual. This in-formation is of utmost importance and caution should be paid before setting the parameters in hearing aid, especially for those who are unable to accept noise. In this review article, an attempt has been made to document how to optimize the hearing aid program by setting parameters such as noise reduction circuit, microphone sensitivity and gain. These adjustments of parameters might help to reduce rejection rate of hearing aids, especially in those individuals who are annoyed by background noise. Copyright ? 2015 The Authors. Production & hosting by Elsevier (Singapore) Pte Ltd On behalf of PLA General Hospital Department of Otolaryngology Head and Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Annoyance Amplification Speech perception in noise Older adults hearing impairment

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GJB2 mutation spectrum in Inner Mongolia and its comparison with other Asian populations

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Journal of Otology 2007年第2期2卷 81-91页

作者： Lee-Jun C. Wong Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas USA

Mutations in the GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the mutation spectrum and prevalence of mutations vary among different ethnic groups. Every year, 30, 000 babies are born with congenital hearing impairment in China. In order to provide appropriate genetic testing and counseling to the family, we investigated the molecular etiology of nonsyndromic deafness in 135 unrelated school children attending Chifeng Municipal Special Education School in Inner Mongolia, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. In addition, the 12S rRNA gene and tRNAser(UCN) of mitochondrial genome were screened for mutations responsible for hearing impairment. Sixty four GJB2 mutant alleles, including 60 confirmed pathogenic alleles and 4 unclassified variants, were identified in 31.1% (42/135) of the subjects. Twenty two subjects carried two pathogenic mutations and 20 subjects carried one mutant allele, including one subject with one autosomal dominant mutation. The 235delC was the most common mutation accounting for 65.6%(42/64) GJB2 mutant alleles. When compared to other Asian populations, our subject cohort had higher frequency of 235delC mutation than the Japanese population. The GJB2 mutant alleles account for 23.7% (64/270) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 4 most prevalent deleterious frame shift mutations(235delC, 29900delAT, 17691del16, and 56005ins46) in this cohort detected 90% of all GJB2 mutant alleles. These results demonstrate that effective genetic testing of the GJB2 gene for patients and families with nonsyndromic hearing impairment is possible in the Chinese population. Since the most common 309kb GJB6 deletion is not detected and only one 1555 A>G mutation in mitochondrial DNA is detected in our patients, investigation of mutations in other nuclear genes and/or environmental factors responsible for nonsyndromic hearin

关键词： GJB2 mutation non-syndromic hearing impairment

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Intracellular Distribution,Assembly and Effect of Disease-associated Connexin 31 Mutants in HeLa Cells

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Acta Biochimica et Biophysica Sinica 2005年第8期37卷 547-554页

作者： Li-Qiang HE~& Yu LIU Fang CAI Zhi-Ping TAN Qian PAN De-Sheng LIANG Zhi-Gao LONG Ling-Qian WU Liang-Qun HUANG He-Ping DAI Kun XIA~* Jia-Hui XIA Zhuo-Hua ZHANG National Laboratory of Medical Genetics,Central South University,Changsha 410078,China 24#,Lane 1400,West Beijing Road,Medical Genetics Institute of Shanghai Jiaotong University.Shanghai,China National Laboratory of Medical Genetics Central South University Changsha 410078 China

Mutations in connexin 31(Cx31)are associated with erythrokeratodermia variabilis(EKV),hearing impairment and peripheral neuropathy;however,the pathological mechanism of Cx31 mutantsremains *** study analyzed 11 disease-associated Cx31 variants and one non-disease-associatedCx31 variant and compared their intracellular distribution and assembly in HeLa cells and their effect onthese *** fluorescent localization assay showed no gap junction plaque formation in the cells expressingthe recessive EKV-associated mutant(L34P)and four hearing impairment-associated mutants(66de1D,141dell,R180X and E183K),significantly reduced plaque formation in the cells with five EKV-associateddominant mutants(G12R,G12D,R42P,C86S and F137L)and no obvious change in the cells with twoother mutants(Ⅰ 141V and 652dei 12).Immunoblotting analysis showed that 12 mutated Cx31 s,like WT-Cx31,are able to form the Triton X-100 insoluble complex;however,the quantity of Triton X-100 insolublecomplex in the transfected HeLa cells varied among different Cx31 ***,the expression offive EKV-associated dominant mutants(G12R,G12D,R42P,C86S and F137L)caused cell death in ***,the five hearing impairment-associated mutants did not induce cell *** above resultssuggest that disease-associated mutants gain deleterious functions *** summary,disease-associated Cx31 mutants impair the formation of normal gap junctions at different levels,and the diseasesassociated with Cx31 mutations may result from the abnormal assembly,trafficking and metabolism of theCx31 mutants.

关键词： connexin 31 erythrokeratodermia variabilis hearing impairment peripheral neuropathy gap junctional intercellular communication(GJIC)

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Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies

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Chinese Medical Journal 2014年第12期127卷 2304-2309页

作者： Liu Yuhe Xue Junfang Zhao Danhua Chen Li Yuan Yun Wang Zhaoxia Department of Otolaryngology Head and Neck Surgery Peking University First HospitalBeijing 100034China Department of Neurology Peking University First Hospital Beijing 100034China

Background hearing impairment has been reported to be common in patients with mitochondrial disorders,a group of diseases characterized by pleiomorphic clinical manifestations due to defects in oxidative phosphorylation of *** study aimed to investigate the audiological characteristics in a large cohort of patients with mitochondrial *** Comprehensive audiological evaluations,including pure tone audiometry,tympanometry,speech audiometry,otoacoustic emissions,electrocochleography and auditory brainstem evoked potentials,were performed in 73 Chinese patients with mitochondrial encephalomyopathy and with confirmed mitochondrial DNA （mtDNA） *** Among the patients,71％ had hearing ***,the incidence rate and severity of hearing impairment were much less in the chronic progressive external ophthalmoplegia （CPEO） subtype than in the mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes （MELAS）,myoclonic epilepsy with ragged red fibers （MERRF） and Kearns-Sayre syndrome （KSS） *** most of our patients had a predominantly cochlea origin for the hearing deficit,five patients had an auditory neuropathy spectrum disorder and three patients had impairment of both cochlea and auditory *** Various portions of the auditory system could be involved in patients with mitochondrial diseases,including cochlea,auditory nerve,auditory pathway and *** loss was more associated with multisystem ***,mutant load of mtDNA and other unknown factors could contribute to heterogeneity of hearing impairment in mitochondrial disease.

关键词： mitochondrial disorder hearing impairment auditory neuropathy spectrum disorder

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hearing Loss in Lassa Fever: A Systematic Review

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Open Journal of Preventive Medicine 2022年第11期12卷 239-247页

作者： Ethel Nkechi Chime Peter Ekpunobi Chime Jones Ndubuisi Nwosu Department of Otorhinolaryngology University of Nigeria Teaching Hospital Ituku-Ozalla Nigeria Department of Otorhinolaryngology Enugu State University of Science and Technology Teaching Hospital Parklane Nigeria Department of Medicine Enugu State University of Science and Technology Teaching Hospital Parklane Nigeria

Background: Lassa fever is a viral haemorrhagic fever associated with several complications which include hearing loss. hearing loss in Lassa fever may become residual with its negative impact on the quality of life. Purpose: This paper is a review of various studies on Lassa fever related hearing loss. Methods: Systematic literature review was done on articles on Lassa fever patients and Lassa fever survivors. Relevant articles published in English between 1969 and 2021 were searched for using Google Scholar and PubMed databases. Eight studies which met the inclusion criteria were finally selected and included in the review. The variables of interest were extracted from the full-text articles. Results: Lassa fever related hearing loss occurs in both sexes and in all age groups. The incidence of self-reported hearing loss ranged from 12.5% to 30% with a mean of 17.6%. The incidence of audiometrically determined sensorineural hearing loss ranged from 13.5% to 29% with a mean of 22.1%. hearing loss persisted in 64% of those that were followed up. Cases of hearing loss varied in severity, ranging from mild to profound. No successful specific treatment for Lassa fever related hearing loss was reported apart from hearing rehabilitation. Conclusion: hearing loss among Lassa fever patients remains a major challenge. Lack of effective treatment for Lassa fever related hearing loss is a serious gap in the management of Lassa fever patients which should be addressed in future research.

关键词： hearing Loss hearing impairment Lassa Fever

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Auditory Clinical Profile of Nightclub Employees in the City of Parakou in 2021

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Open Journal of Epidemiology 2023年第2期13卷 144-150页

作者： Ibrahim Mama Cissé Ahoya Christophe Fabien Gounongbé Ménonli Adjobimey Carmen Abatti Fatiou Ibouraima Khadidjatou Saké Marius Flatin Department of Occupational Health Research Unit University of Parakou Parakou The Republic of Benin Department of Medicine and Medical Specialties University of Abomey-Calavi Abomey-Calavi The Republic of Benin

Introduction: hearing impairments are common among nightclub workers. The present work aims to study the hearing clinical profile of these employees in the city of Parakou in 2021. Methods: This was a cross-sectional, descriptive analytical study from March 14 to June 15, 2021. It focused on employees of 13 nightclubs in the city of Parakou. Were included in the study, employees with at least 03 months of practice and aged at least 18 to 50 years at most on the date of the survey and who had given their informed consent to participate in the study. Each employee received a questionnaire, an otoscopy and an acoumetry in tune. Noise pollution was measured at each workstation using a sound level meter. Results: A total of 114 employees were collected. The mean age was 26.38 years ± 4.81 and the sex ratio 0.87. The server position was occupied by 65 employees (57%) followed by managers, 19 or 16.70%- and 17-disc jockeys, 14.90%. Among the employees 31.60% exercised between 03 and 09 months. 76.32% were exposed to noise for more than 8 hours per day and 81.58% were exposed to noise for more than 40 hours per week. The sound level at the workstation was for 59 employees (51.75%) between 90 and 100 dB. Tinnitus was the most expressed complaint, respectively 21 (18.40%) on the right and 22 (19.30%) on the left. Rinne’s test was positive in 85.10% of employees. Weber’s test was indifferent to all frequencies in the majority of respondents. Conclusion: hearing damage among nightclub employees in the city of Parakou is a reality. It is important to put preventive measures in place.

关键词： hearing impairment Noise Nightclubs Parakou Benin 2021

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