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Chinese Medical Journal 2013年第16期126卷 3048-3052页

作者： MO Xiao-dong XU Lan-ping LIU Dai-hong CHEN Yu-hong ZHANG Xiao-hui CHEN Huan HAN Wei WANG Yu WANG Feng-rong WANG Jing-zhi LIU Kai-yan HUANG Xiao-jun Peking University People's Hospital & Institute of Hematology Beijing Key laboratory of Hematopoitic Stem Cell TransplantationBeijing 100044 China

Background Chronic graft-versus-host disease （GVHD）,the commonest long-term complication after allogeneic hematopoietic stem cell transplantation （HSCT）,has a negative impact on patients＇ health related quality of life （HRQoL）.This study was designed to investigate the HRQoL in patients with chronic GVHD in *** Two hundred and sixty-four patients with chronic GVHD who were ＞24 months post-HSCT and had been in continuous complete remission since HSCT were enrolled in this retrospective *** was evaluated using an SF-36 *** analysis was used to identify the factors that affect HRQoL in patients with chronic *** HRQoL in patients categorized as having mild and moderate chronic GVHD was significantly better than in those in the severe *** the moderate chronic GVHD category,markedly poorer HRQoL was observed in patients with both multiple organ involvement and more severe organ impairment than in those without these *** to multivariate analysis,chronic GVHD severity had the greatest significant negative impact on patients＇ HRQoL; whereas being female was associated with a negative impact on psychological *** Chronic GVHD severity strongly correlates with negative impacts on patients＇ HRQoL.

关键词： chronic graft-versus-host disease health related quality of life National Institutes of health consensus criteria

Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第42期20卷 15787-15796页

作者： Tibor Hlavaty Anna Krajcovicova Tomas Koller Jozef Toth Monika Nevidanska Martin Huorka Juraj Payer Department of Internal Medicine Division of Gastroenterology and Hepatology University Hospital Bratislava Department of Internal Medicine Center for Osteoporosis and Metabolic Bone Diseases University Hospital Bratislava

AIM: To investigate the effect of vitamin D (VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease (IBD) patients.

关键词： Vitamin D Crohn’ s disease Ulcerative colitis health related quality of life Vitamin D supplementation

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Journal of Diabetes Mellitus 2022年第4期12卷 243-251页

作者： Md. Motiur Rahman Hafiza Sultana Farkhanda Mah Jebin Tanmoy Saha Wahida Yasmeen Foisal Mohammad Mosiul Alom Syeda Tahmina Ferdous Jinia Syed Ahmed Laiak Ahammed Sheikh Sayera Khatun Medical College and Hospital Gopalganj Bangladesh National Institute of Preventive & Social Medicine (NIPSOM) Dhaka Bangladesh Khwaja Yunus Ali Medical College Sirajganj Bangladesh Tooth Fairy Foundation Dhaka Bangladesh Udayan Dental College Rajshahi Bangladesh National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR) Dhaka Bangladesh Institute of Epidemiology Disease Control and Research (IEDCR) Dhaka Bangladesh Bangabandhu Sheikh Mujib Medical College Fraidpur Bangladesh

Introduction: The health related quality of life (HRQoL) has an important role in adults suffering from diabetes. Objective: To assess the health related quality of life in adult with type 2 diabetes mellitus. Materials and methods: A cross-sectional study was conducted to assess diabetic patient’s HRQoL on 119 purposively selected type-2 DM patients (aged ≥ 18 years and duration of diabetes ≥ 1 year). Data were collected by face-to-face interview and by medical record review through a Bangle version of SF-36 semi-structured questionnaire and a checklist. Place and period of study: The study was conducted at outpatient department in Gopalganj 50 bedded diabetic hospital from 1st January, 2018 to 31st December 2018. Results: The mean age of the respondents was 52.34 (SD ± 10.19) years. Age group shows a significant difference associated with all domains of quality of life except role emotion (>0.05), gender shows the significant in social and pain domain (0.05) respectively co-morbidity shows the significant difference with all domains expect pain (>0.05). Physical functioning, emotional, pain and general health of the quality of life show the significant difference associated with use of insulin (Conclusion: The overall QoL of type-2 DM patients was poor and had lower score of health related quality of life.

关键词： Type 2 Diabetes Mellitus health related quality of life Diabetes Mellitus

Prevalence of hypertension among individuals aged 50 years and over and its impact on health related quality of life in a semi-rural area of western TUrkey

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Chinese Medical Journal 2008年第16期121卷 1524-1531页

作者： Didem Arslantas Unal Ayranci Alaettin Unsal Mustafa Tozun Osmangazi University Medical Faculty Public Health Department 26480 Meselik-Eskisehir Turkey Osmangazi University Medico-Social Center 26480 Meselik- Eskisehir Turkey

Background Hypertension is common, especially in individuals aged 40 years and over, and it affects about half of the population aged 60 years and over. This study aimed to determine the frequency and risk factors of hypertension among individuals aged 50 years and over, and to examine its effect on the health related quality of life （HRQOL）. Methods This population-based cross-sectional study was conducted in two settlements in a region of western Turkey between March 1 and April 30, 2007. A questionnaire concerning life habits associated with hypertension, medical histories, and demographic characteristics was filled in by a face to face interview. The SF-36 scale was used to assess HRQOL. Body mass index （BMI） was calculated by measuring the weight and length of the body. Results Of 1599 individuals living in the region, 1193 participated in the survey （48.3% men and 51.7% women）. The overall prevalence rate of hypertension was 59.5% （n=-710）, being 58.0% in men and 60.9% in women （P 〉0.05）. The variables that most positively influenced hypertension （P ≤0.05, for each one） were older age （especially the age group of those aged 60 and over）, single, no health insurance, consumption of animal fat in meals, and family history of hypertension. The HRQOL of the patients with hypertension was lower than that of those without hypertension （P ≤0.05）. The HRQOL was better in hypertensive patients whose blood pressure was under control, whereas it was worse in those with at least one chronic disorder accompanying hypertension （P≤0.05, for each one）. Conclusions Great emphasis should be placed on the need for a public health program for the detection, prevention, and control of hypertension, including other risk factors, as well as for the modification of foods and life habits, specifically in individuals who are most likely to be at risk of hypertension.

关键词： hypertension bloodpressure prevalence health related quality of life elderly people

Associated factors of self-reported psychopathology and health related quality of life among men who have sex with men (MSM) with HIV/AIDS in Dalian, China: a pilot study

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Infectious Diseases of Poverty 2016年第1期5卷 993-1002页

作者： Tesfaldet Habtemariam Hidru Feng Wang Sainyugu Lolokote Yong Jia Min Chen Wei Tong Xiao-Feng Li Department of Epidemiology and Biostatistics Dalian Medical UniversityDalianLiaoning 116044People’s Republic of China School of Public health Dalian Medical UniversityDalianLiaoning 116044People’s Republic of China Department of HIV/AIDS Dalian Center for Disease Control and PreventionDalian 116023LiaoningPeople’s Republic of China

Background:Despite the availability of Anti-Retroviral Therapy(ART),the health-related quality of life(HRQoL)among HIV-positive men who have sex with men(HIVMSM)in China remains *** study aimed to explore the relationship between self-reported psychopathology and HRQoL among HIVMSM in Dalian,***:A cross-sectional study was conducted in 112 *** check list 90(SCL 90):a measure of psychopathology and World health Organization quality of life in HIV infection(WHOQOL-HIV-Bref):a measure of HRQoL were *** and multiple regression analysis were employed to explore the association between self-reported psychopathology and HRQoL in ***:Out of the total 112 HIVMSM cases,9(8%)cases were homosexuals and 103(92%)ones were *** participants who had low family income(P=0.001),perceived discrimination(P=0.001)and lack of regular attendance in medical follow-ups(P=0.014)reported poorer HRQoL than their ***,obsession,depression,phobia and overall SCL 90 scores in self-reported psycholpathology had a negative impact on the domains of HRQoL among ***:Total quality of life was predicted by family income,perceived discrimination,and medical follow-up ***-reported psychopathology was negatively correlated with HRQoL in *** Strategies that target MSM focusing on linking and engaging HIV-positive patients in medical care is the key step to improve their *** emphasis is needed on the newly diagnosed HIVMSM in Dalian in order to develop a more targeted intervention to prevent perceived discrimination and lack of proper medical follow-up *** registration:The trial registration number does not require for this *** study is cross-sectional design that do not involve intervention at all,it is not a clinical trial.

关键词： Men who have sex with men HIV/AIDS Psychopathology Mental health health related quality of life

A Review of Systemic Lupus Erythematosus (SLE): Symptoms, Risk Factors, Treatment, and health related quality of life Issues

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第4期11卷 115-143页

作者： Sarah N. Al-Gahtani Department of Internal Medicine King Fahd Medical City Riyadh Saudi Arabia

In this paper, we present a thorough review of one of the most life-threatening autoimmune diseases, Systemic lupus erythematosus (lupus). Symptoms, risk factors, including genetic and epidemiological factors are discussed. Treatment, life expectancies, and health related quality of life of patients with SLE will be discussed as well. Special attention will be given to Lupus Nephritis.

关键词： Autoimmune Disorders Systemic Lupus Erythematosus Environmental Risk Factors Familial Aggregation Lupus Nephritis Treatment of SLE health related quality of life

Influence of anxiety/depression on health related quality of life of patients with various pacing modes

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South China Journal of Cardiology 2010年第1期11卷 34-40,45页

作者：梅百强区丽明陈剑区展鹏郑伊颖马欢黄晔磊朱春燕 Department of Cardiology Guangdong Cardiovascular Institute Guangdong Academy of Medical Sciences Guangdong Provincial People's Hospital Stomatology Hospital Liwan District

Background The thesis is to study the influence of anxiety/depression on health related quality of life （HRQoL） of patients with various pacing modes a month after they have had a pacemaker implanted. Methods HRQoL was assessed consecutively in patients （50 men, 48 women, mean age 52.7±14.1 years） with implanted pacemaker （PM） from June to December 2009 in our hospital （22 patients received VVI pacemaker, 26 received VVIR pacemaker, 26 received DDD pacemaker, 24 received DDDR pacemaker）. HRQoL was measured by the SF-36 and Aquarel questionnaires, anxiety by Zung anxiety scale （SAS） and depression by Zung depression scale （SDS）. Results Patients with rate-adaptive pacing had higher scores in SF-36 scales （health perception, vitality, social functioning and mental health） and Aquarel （chest pain, dyspnea and arrhytmia）; they also presented lower degree of anxiety and depression compared with those with non-rate-adaptive pacing. Differences were shown only in the group with dual chamber pacemakers, but not in the group with single chamber pacemakers. Significant differences were observed between patients with single chamber and dual chamber PM in rate-adaptive pacing. There was a strong correlation between the degree of anxiety and depression and the HRQoL for pacemaker patients. Conclusion Dual chamber rate-adaptive pacing offers better HRQoL and psychological profile than dual chamber non-rate-adaptive pacing. Significant improvement in five SF-36 subscales was observed with DDDR pacing compared with VVIR pacing. Anxiety and depression are important factors in the HRQoL of patients with implanted pacemakers. Early detection and intervention in patients with psychological problems are imperative.

关键词： anxiety depression cardiac pacing health related quality of life

Temperament and character as predictor of health related quality of life after metacarpophalangeal joint arthroplasty ——Personality and MCP joint arthroplasty outcome

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health 2010年第9期2卷 1101-1109页

作者： Sven Brandstrom Kurt Pettersson Jorg Richter Department of Neuroscience and Locomotion Division of Psychiatry Linkoping UniversityLinkopingSweden Department of Hand Surgery Orebro University HospitalOrebroSweden Department of Psychology Center for Child and Adolescent Mental HealthOsloNorway

Purpose: To evaluate personality characteris- tics’ impact upon outcome after silicone-based MP arthroplasty in RA patients. Methods: 40 RA patients who had undergone operations on their MP joints were investigated in a one-year fol- low-up. Objective measurement to assess grip strength and active range of motion—Paper- pencil-tests to assess pain during activity and at rest performance, QoL, and personality. Results: Significant improvement was observed in func- tion and pain related scores except for the pain related VAS and in several QoL facets and do- mains. Patients who experienced improvement reported higher scores on the activities of daily living facet of the WHO QoL questionnaire. Those with lower pain showed more independ- ence. The variance of the QoL domain scores, other than social and physical domains, could substantially and meaningfully be explained by variance of objective measures combined with personality scores. Conclusions: Most RA pa- tients’ QoL can be improved by MP arthroplasty despite remaining substantial level of pain. NS and HA seem to play an important role in the adaptation process during the long term, chronic illness;whereas SD represents a tool of coping with the burden of pain and disability. Personal- ity characteristics are highly predictive for QoL suggesting their important mediating role be- tween experienced pain and disability and HR QoL.

关键词： Rheumatoid Arthritis health related quality of life MP Joint Arthroplasty Temperament Character

Hepatitis C virus eradication with directly acting antivirals improves health-related quality of life and psychological symptoms

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World Journal of Gastroenterology 2019年第48期25卷 6928-6938页

作者： Silvia Nardelli Oliviero Riggio Davide Rosati Stefania Gioia Alessio Farcomeni Lorenzo Ridola Department of Translational and Precision Medicine “Sapienza”University of RomeRome 00185Italy Department of Economics&Finance University of Rome“Tor Vergata”Rome 00185Italy

BACKGROUND Alterations in health-related quality of life(HRQoL)and neuropsychological disorders were described in the hepatitis C virus(HCV)*** several studies investigated the modifications of HRQoL after HCV eradication,no data exists on the modifications of neuropsychological *** To investigate the effect of directly acting antivirals(DAAs)treatment on HRQoL and neuropsychological *** Thirty nine patients with HCV infection underwent a neuropsychological assessment,including Zung-Self Depression-Rating-Scale,Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs *** was detected by Short-Form-36(SF-36).RESULTS All HRQoL domains,but role limitation physical and bodily pain,significantly improved after ***,after DAAs treatment,all domains of HRQoL returned similar to those of *** neuropsychological test significantly improved after HCV eradication.A significant correlation was observed among each psychological test and the summary components of *** multiple linear regression analysis including each psychological test as possible covariates,Zung-Self Depression Rating Scale(Zung-SDS)score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the *** Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.

关键词： Hepatitis C virus health related quality of life Depression State and trait anxiety Alexithymia Directly acting antivirals