Health related quality of life among patients with chronic graft-versus-host disease in China
Health related quality of life among patients with chronic graft-versus-host disease in China作者机构：Peking University People's Hospital & Institute of HematologyBeijing Key laboratory of Hematopoitic Stem Cell TransplantationBeijing 100044 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2013年第126卷第16期
页 面：3048-3052页
核心收录：
学科分类：0710[理学-生物学] 02[经济学] 0201[经济学-理论经济学] 1002[医学-临床医学] 07[理学] 020105[经济学-世界经济] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：This work was partly supported by the National High Technology Research and Development Program of China (Program 863 No. 2011AA020105) and the National Natural Science Foundation of China (No. 30971292).Acknowledgment: This manuscript has been edited by Lena R and Ryan L of American Journal Experts
主 题：chronic graft-versus-host disease health related quality of life National Institutes of Health consensus criteria
摘 要：Background Chronic graft-versus-host disease （GVHD）,the commonest long-term complication after allogeneic hematopoietic stem cell transplantation （HSCT）,has a negative impact on patients＇ health related quality of life （HRQoL）.This study was designed to investigate the HRQoL in patients with chronic GVHD in *** Two hundred and sixty-four patients with chronic GVHD who were 24 months post-HSCT and had been in continuous complete remission since HSCT were enrolled in this retrospective *** was evaluated using an SF-36 *** analysis was used to identify the factors that affect HRQoL in patients with chronic *** HRQoL in patients categorized as having mild and moderate chronic GVHD was significantly better than in those in the severe *** the moderate chronic GVHD category,markedly poorer HRQoL was observed in patients with both multiple organ involvement and more severe organ impairment than in those without these *** to multivariate analysis,chronic GVHD severity had the greatest significant negative impact on patients＇ HRQoL; whereas being female was associated with a negative impact on psychological *** Chronic GVHD severity strongly correlates with negative impacts on patients＇ HRQoL.
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