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Association between Baseline SBP/DBP and All-Cause Mortality in Residents of Shanxi,China:A Population-based Cohort Study from 2002 to 2015

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Biomedical and Environmental Sciences 2021年第1期34卷 1-8页

作者： WANG Zhuo Qun ZHAI Yi LI Man YANG Xiu Feng ZHANG Jian REN Ze Ping ZHANG Mei SONG Peng Kun ZHAO Yan Fang MI Sheng Quan ZHANG Lu YANG Mao Xiang ZHAO Wen Hua National Center for Chronic and Noncommunicable Disease Control and Prevention China CDCBeijing 100050China Beijing Tian tan Hospital Capital Medical UniversityChina National Clinical Research Center for Neurological DiseasesBeijing 100070China Hebei Key Laboratory of Environment and Human Health Department of Epidemiology and StatisticHebei Medical UniversityShijiazhuang 050017HebeiChina Xinfu Center for Disease Control and Prevention Xinfu 034000ShanxiChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Shanxi Center for Disease Control and Prevention Taiyuan 030012ShanxiChina College of Biochemical Engineering Beijing Union UniversityBeijing 100023China

Objective To investigate the association between blood pressure and all-cause mortality in Shanxi,*** The‘2002 China Nutrition and Health Survey’baseline data in Shanxi province was used.A retrospective investigation was performed in *** effects of SBP and DBP on the all-cause mortality were analyzed using the Cox regression *** hazard ratio(HR)and 95%confidence interval(CI)were estimated by the sex and age *** The follow-up rate was 76.52%over 13 years,while the cumulative mortality rate for all participants was 917.12/100,000 *** mortality rose with an increasing SBP(χ_(trend)^(2)=270.537,P60-year-old *** with DBP≥100 mm Hg had a significantly higher mortality,with an HR(95%CI)of 2.715(1.377–5.351).Conclusion Adults with SBP>160 mm Hg and DBP>100 mm Hg had a higher mortality *** and age difference was noted in both DBP and mortality risk.

关键词： Blood pressure Mortality Cohort study hazard ratio Shanxi province

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Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1412-1423页

作者： Yun-Ji Xu Hong-Jie He Peng Wu Wen-Bing Li Department of General Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)has very low overall *** to global cancer statistics,approximately 905677 new cases were reported in 2020,with at least 830180 of them being *** of differentiation 147(CD147)is a novel,transmembrane glycoprotein that is expressed in a wide variety of tumor cells and plays an important role in various stages of tumor *** on the reports described previously,we theorize that CD147 may be used as a novel biological indicator to predict the prognosis of *** study this possibility,expression profiles of CD147 and corresponding clinical data from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases were analyzed,and a hazard ratio(HR)was *** To explore the pattern of CD147 expression and its applicability in the prognosis of *** establish HRs and probability points for predicting the prognosis of HCC by correlating CD147 expression with clinical *** determine if CD147 can be a reliable biomarker in HCC *** The CD147 expression profile in HCC and corresponding clinical data were obtained from TCGA *** expression patterns of CD147 were then validated by analyzing data from the GEO *** addition,CD147 immunohistochemistry in HCC was obtained from the Human Protein ***147 expression patterns and clinical characteristics in the prognosis of HCC were analyzed by accessing the UALCAN web ***,sensitivity,and specificity of the CD147 expression profile in predictive prognosis were determined by the time-dependent receiver operating characteristic(ROC)***-Meier curves were plotted to estimate the HR of survival in *** and multivariate Cox regression proportional hazards analyses of CD147 expression levels and clinical characteristics as prognostic factors of HCC were *** were used to establish probability points and predict *** Data from TCGA and GEO databa

关键词： Hepatocellular carcinoma Cluster of differentiation 147 Prognosis Clinical characteristics hazard ratio

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Meta-analysis of outcomes from drug-eluting stent implantation in infrapopliteal arteries

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World Journal of Clinical Cases 2023年第22期11卷 5273-5287页

作者： Ming-Xuan Li Hai-Xia Tu Meng-Chen Yin Department of Vascular Surgery Beijing Fengtai You'anmen HospitalBeijing 100069China

BACKGROUND Percutaneous drug-eluting stent implantation(DESI)is an emerging and promising treatment modality for infrapopliteal artery diseases(IPADs).This systematic review and meta-analysis summarizes and quantitatively analyzes the outcomes of DESI in IPADs considering the hazard ratio(HR),which is a more accurate and appropriate outcome measure than the more commonly used relative risk and odds *** To explore the superiority of drug-eluting stents(DESs)vs traditional treatment modalities for *** The following postoperative indicators were the outcomes of interest:All-cause death(ACD)-free survival,major amputation(MA)-free survival,target lesion revascularization(TLR)-free survival,adverse event(AE)-free survival,and primary patency(PP)*** outcome measures were then compared according to their respective HRs with 95%confidence intervals(CIs).The participants were human IPAD patients who underwent treatments for infrapopliteal *** was set as the intervention arm,and traditional percutaneous transluminal angioplasty(PTA)with or without bare metal stent implantation(BMSI)was set as the control arm.A systematic search in the Excerpta Medica Database(Embase),PubMed,Web of Science,and Cochrane Library was performed on November 29,*** controlled studies published in English with sufficient data on outcomes of interest for extraction or conversion were *** studies did not directly report the HRs but gave a corresponding survival curve,we utilized Engauge Digitizer software and standard formulas to convert the information and derive ***,meta-analyses were conducted using a random-effects *** Five randomized controlled trials and three cohort studies involving 2639 participants were *** ACDfree and MA-free survival HR values for DESI were not statistically significant from those of the control treatment(P>0.05);however,the HR values for TLR-free,AE-free,and PP-survival differed significantly[2.65(95%

关键词： Infrapopliteal Drug-eluting stent Below-the-knee Meta-analysis hazard ratio

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Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2796-2807页

作者： Minseob Kim Kyung-Do Han Seung-Hyun Ko Yoonkyung Woo Jae Hyun Han Department of Surgery Graduate School of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Division of Endocrinology and Metabolism Department of Internal MedicineSt Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247South Korea Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation Department of SurgerySt Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247South Korea

BACKGROUND The role of smoking in the incidence of colorectal cancer(CRC)or gastric cancer(GC)in populations undergoing cholecystectomy has not been *** To evaluate the effect of smoking on CRC or GC development in cholecystectomy *** A total of 174874 patients who underwent cholecystectomy between January 1,2010 and December 31,2017 were identified using the Korean National Health Insurance Service claims *** patients were matched 1:1 with mem-bers of a healthy population according to age and *** or GC risk after cholecystectomy and the association between smoking and CRC or GC risk in cholecystectomy patients were evaluated using adjusted hazard ratios(HRs)and 95%*** The risks of CRC(adjusted HR:1.15;95%CI:1.06-1.25;P=0.0013)and GC(adjusted HR:1.11;95%CI:1.01-1.22;P=0.0027)were significantly higher in cholecystectomy *** the population who underwent cholecystectomy,both CRC and GC risk were higher in those who had smoked compared to those who had never *** both cancers,the risk tended to increase in the order of non-smokers,ex-smokers,and current *** addition,a positive correlation was observed between the amount of smoking and the risks of both CRC and *** Careful follow-up and screening should be performed,focusing on the increased risk of gastrointestinal cancer in the cholecystectomy group,particularly considering the individual smoking habits.

关键词： Cholecystectomy Smoking,Gastric cancer Colon cancer Risk factor hazard ratio

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Higher risk of type 2 diabetes in young women with polycystic ovary syndrome: A 10-year retrospective cohort study

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World Journal of Diabetes 2022年第3期13卷 240-250页

作者： Wan-Ting Liao Jing-Yang Huang Ming-Tsung Lee Yu-Cih Yang Chun-Chi Wu Institute of Medicine Chung-Shan Medical UniversityTaichung 402Taiwan Chinese Medicine Department Show Chwan Memorial HospitalChanghua 500Taiwan Research Center for Health Data Science Chung Shan Medical University HospitalTaichung 402Taiwan National Center for Geriatrics and Welfare Research National Health Research InstitutesYunlin 632Taiwan Clinical Trial Research Center China Medical University HospitalTaichung 404Taiwan

BACKGROUND Polycystic ovary syndrome(PCOS)is a common disorder in women of reproductive *** the last few decades,research studies have revealed that PCOS is strongly associated with metabolic disorders,including metabolic syndrome,obesity,insulin resistance and *** observation has shown that women with PCOS are expected to have an increased risk of developing type 2 diabetes(T2DM)in the *** To assess the hazard ratio(HR)of T2DM between women with/without *** This population-based,retrospective cohort study evaluated data retrieved from the National Health Insurance Research *** subjects were women with PCOS(n=2545)identified on the basis of diagnosis,testing,or treatment codes,and women without PCOS as controls(n=2545).The HR of T2DM between women with or without PCOS was the main outcome measure *** Our study found that, during a 10-year follow-up period, the overall incidence of T2DM was 6.25per 1000 person-years in the PCOS group compared with 1.49 in the control group. Afteradjustment for potential confounding variables, the overall incidence of T2DM was higher in thePCOS group vs the control group (HR = 5.13, 95%CI: 3.51-7.48, P < 0.0001). The risk of developingT2DM subsequent to PCOS decreased with increasing diagnosis age: the adjusted HR was 10.4 inthe 18–24-year age group, 5.28 in the 25-29-year age group, and 4.06 in the 29-34-year age ***, no such significant association was noted in women older than 35 *** findings highlight the importance of prompting a more aggressive treatment to preventdiabetes in women diagnosed with PCOS at a young age, and, in contrast, the lessened importanceof this type of intervention in women diagnosed with PCOS at a late reproductive age.

关键词： Polycystic ovary syndrome Diabetes Incidence hazard ratio Population-based cohort study

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Nutritional epidemiology methods and related statistical challenges and opportunities

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Statistical Theory and Related Fields 2018年第1期2卷 2-10页

作者： Ross L.Prentice Ying Huang Fred Hutchinson Cancer Research Center and University of Washington SeattleWAUSA

The public health importance of nutritional epidemiology research is discussed,along withmethodological challenges to obtaining reliable information on dietary approaches to chronicdisease *** issues in assessing dietary intake need to be addressed toobtain reliable disease association ***-reported dietary data typically incorporatemajor random and systematic *** biomarkers offer potential for more reliable analyses,but biomarkers have been established only for a few dietary variables,and these may be tooexpensive to apply to all participants in large epidemiologic cohorts.A possible way forwardinvolves additional nutritional biomarker development using high-dimensional metabolomicprofiling,using blood and urine specimens,in conjunction withfurther development of statisticalapproaches for accommodating measurement error with failure time response *** the opportunity to contribute greatly to worldwide public health through the development of statistical methods to address these nutritional epidemiology research challenges,asis elaborated in this contribution.

关键词： Chronic disease epidemiology failure time data hazard ratio measurement error metabolomics nutritional biomarker regression calibration

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A population-based cohort study of symptomatic gallstone disease in diabetic patients

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World Journal of Gastroenterology 2012年第14期18卷 1652-1659页

作者： Chi-Ming Liu Chung-Te Hsu Chung-Yi Li Chu-Chieh Chen Meng-Lun Liu Jorn-Hon Liu Department of Medical Research and Education Division of General SurgeryCheng-Hsin General HospitalTaipei 11220TaiwanChina Division of Gastroenterology Cheng-HsinGeneral Hospital National Defense Medical Center Taipei11220 Taiwan China Institute of Public Health Yang-Ming Univer-sity Taipei 11220 Taiwan China Department of Health Care Management National Taipei University of Nursing and Health SciencesTaipei 11257TaiwanChina Division of General Surgery Cheng-Hsin General HospitalTaipei 11220TaiwanChina Dean＇s Office Cheng-Hsin General HospitalTaipei 11220TaiwanChina Jorn-Hon LiuDepartment of MedicineSchool of MedicineNational Yang-Ming UniversityTaipei 11220TaiwanChina

AIM:To investigate the prevalence of gallstone dis-ease(GSD) and to evaluate the risk of symptomatic GSD among diabetic ***:The study was conducted by analyzing the National Health Research Institutes(NHRI) dataset of ambulatory care patients,inpatient claims,and the updated registry of beneficiaries from 2000 to 2008.A total of 615 532 diabetic patients without a prior history of hospital treatment or ambulatory care visits for symptomatic GSD were identified in the year ***-and gender-matched control individuals free from both GSD and diabetes from 1997 to 1999 were randomly selected from the NHIR database(n = 614 871).The incidence densities of symptomatic GSD were estimated according to the subjects' diabetic *** distributions of age,gender,occupation,income,and residential area urbanization were compared between diabetic patients and control subjects using Cox proportion hazards *** between the rates of selected comorbidities were also assessed in the two ***:Overall,60 734 diabetic patients and 48 116 control patients developed symptomatic GSD and underwent operations,resulting in cumulative operation rates of 9.87% and 7.83%,*** age and gender distributions of both groups were similar,with a mean age of 60 years and a predominance of *** diabetic group had a significantly higher prevalence of all comorbidities of interest.A higher incidence of symptomatic GSD was observed in females than in males in both *** the control group,females under the age of 64 had a significantly higher incidence of GSD than the corresponding males,but this difference was reduced with increasing *** cumulative incidences of operations for symptomatic GSD in the diabetic and control groups were 13.06 and 9.52 cases per 1000 person-years,*** men exhibited a higher incidence of operations for symptomatic GSD than did their counterparts in the control group(12.35 vs 8.75 cases per 1000 pe

关键词： Gallstone disease Diabetes Symptomatic Incidence density hazard ratio

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Clinicopathological and prognostic role of CEP55 expression in cancer patients:A meta‐analysis of 31 studies with 12,543 patients

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iLABMED 2024年第4期2卷 327-340页

作者： Jiangguo Zhang Xiaoyin Zhang Department of Gastroenterology Shenzhen Third People's HospitalShenzhenGuangdongChina The Second Affiliated Hospital of Southern University of Science and Technology ShenzhenGuangdongChina

Background:Dysregulated expression of centrosomal protein 55(CEP55)has been detected in multiple types of ***,the clinical value of CEP55 expression in cancer is *** current meta-analysis quantitatively investigated the association between CEP55 expression and prognostic outcomes in ***:A literature search was performed using the Chinese National Knowledge Infrastructure(CNKI),Wanfang databases,Web of Science,Embase,MEDLINE,PubMed,and Cochrane Library for primary *** pooled hazard ratios(HRs)and odds ratios(ORs)were used to investigate the association between CEP55 expression and its prognostic and clinicopatho-logical value in ***:A total of 12,543 patients from 31 studies were included in this *** CEP55 expression was significantly associated with poor dif-ferentiation,deeper tumor invasion and increased lymph node metastasis in cancer *** pooled results indicated that elevated CEP55 expression can predict a poor overall survival(OS)and disease-free survival(DFS)in *** results should be interpreted with caution because of publi-cation ***,the pooled HR for OS of lung cancers was 1.50(95%CI=1.36-1.67,p<0.01)with no heterogeneity and publication ***:CEP55 overexpression correlated with poor cancer differentia-tion,deeper tumor invasion,and increased lymph node metastasis,suggesting that CEP55 may serve as a predictive and prognostic biomarker for cancers,especially for lung cancers.

关键词： cancer centrosomal protein 55 clinicopathological significance hazard ratio odds ratio prognostic significance

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The Cox Proportional hazard Regression Model Vis-à-Vis ITN-Factor Impact on Mortality Due to Malaria

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Open Journal of Statistics 2021年第6期11卷 931-962页

作者： Anthony Joe Turkson John Awuah Addor Francis Ayiah-Mensah Department of Mathematics Statistics and Actuarial Science Takoradi Technical University Takoradi Ghana

This study has provided a starting point for defining and working with Cox models in respect of multivariate modeling. In medical researches, there may be situations, where several risk factors potentially affect patient prognosis, howbeit, only one or two might predict patient’s predicament. In seeking to find out which of the risk factors contribute the most to the survival times of patients, there was the need for researchers to adjust the covariates to realize their impact on survival times of patients. Aside the multivariate nature of the covariates, some covariates might be categorical while others might be quantitative. Again, there might be cases where researchers need a model that has the capability of extending survival analysis methods to assessing simultaneously the effect of several risk factors on survival times. This study unveiled the Cox model as a robust technique which could accomplish the aforementioned cases. An investigation meant to evaluate the ITN-factor vis-à-vis its contribution towards death due to Malaria was exemplified with the Cox model. Data were taken from hospitals in Ghana. In doing so, we assessed hospital in-patients who reported cases of malaria (origin state) to time until death or censoring (destination stage) as a result of predictive factors (exposure to the malaria parasites) and some socioeconomic variables. We purposefully used Cox models to quantify the effect of the ITN-factor in the presence of other risk factors to obtain some measures of effect that could describe the relationship between the exposure variable and time until death adjusting for other variables. PH assumption holds for all three covariate

关键词： Baseline hazard Cox Model hazard Function hazard ratio Survival Function

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Biomechanical Considerations in the Unruptured Cerebral Aneurysm Study (UCAS Japan): Rupture Risk and True Stress of Wall

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Journal of Biosciences and Medicines 2021年第10期9卷 172-189页

作者： Fumio Nogata Yasunari Yokota Yoko Kawamura Hiroyuki Morita Yoshiyuki Uno Tetsuya Mouri William R. Walsh Takakahiko Kawamura Nigishi Hotta Kenji Kagechika Gifu University Gifu Japan Department of Electrical Electronic and Computer Engineering Faculty of Engineering Gifu University Gifu Japan Faculty of Engineering Gifu University Gifu Japan Department of General Medicine and General Internal Medicine Gifu University Graduate School of Medicine Gifu Japan Department of General Medicine Gifu Prefectural General Medical Center Gifu Japan Department of Mechanical Engineering Faculty of Engineering Gifu University Gifu Japan Prince of Wales Hospital University of New South Wales Kensington Australia Chubu Rosai Hospital Aichi Japan Diabetes and Endocrine Internal Medicine Nagoya Japan Nagoya University and Chubu Rosai Hospital Internal Medicine Nagoya Japan Toyama Prefectural Rehabilitation Hospital and Support Center for Children with Disabilities Toyama Japan

When an unruptured aneurysm is found, deciding whether to operate or follow up is one of the most important issues. There are guidelines for making the best final decision on treatment, taking into account the effectiveness of diagnostic and therapeutic devices and the risk-benefit ratio of patients, caregivers, and healthcare professionals. The guidelines evidence-based of large clinical data for this purpose are presented by national medical societies. As one of the rupture risk indicators, there is the hazard risk ratio derived by the UCAS Japan research group based on the statistical method of 6697 aneurysms in 5720 patients with cerebral aneurysms of 3 mm or more. Therefore, we investigated the biomechanical significance of this hazard risk ratio using a spherical aneurysm model. It was revealed that 1) the reason why the frequency of aneurysm rupture is relatively high up to about 10 mm, 2) the UCAS hazard risk ratio corresponds to stress of the aneurysm wall, and the true stress can be calculated by multiplying the patient’s blood pressure, and 3) the factors that cause the daughter’s sac (irregular protrusion of the aneurysm wall). In addition, our two methods for measuring the strength of the blood vessel wall of an individual patient were described.

关键词： Cerebral Aneurysm Rupture Risk UCAS hazard ratio Biomechanics

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