Meta-analysis of outcomes from drug-eluting stent implantation in infrapopliteal arteries
作者机构：Department of Vascular SurgeryBeijing Fengtai You'anmen HospitalBeijing 100069China
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2023年第11卷第22期
页 面：5273-5287页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Infrapopliteal Drug-eluting stent Below-the-knee Meta-analysis Hazard ratio
摘 要：BACKGROUND Percutaneous drug-eluting stent implantation(DESI)is an emerging and promising treatment modality for infrapopliteal artery diseases(IPADs).This systematic review and meta-analysis summarizes and quantitatively analyzes the outcomes of DESI in IPADs considering the hazard ratio(HR),which is a more accurate and appropriate outcome measure than the more commonly used relative risk and odds *** To explore the superiority of drug-eluting stents(DESs)vs traditional treatment modalities for *** The following postoperative indicators were the outcomes of interest:All-cause death(ACD)-free survival,major amputation(MA)-free survival,target lesion revascularization(TLR)-free survival,adverse event(AE)-free survival,and primary patency(PP)*** outcome measures were then compared according to their respective HRs with 95%confidence intervals(CIs).The participants were human IPAD patients who underwent treatments for infrapopliteal *** was set as the intervention arm,and traditional percutaneous transluminal angioplasty(PTA)with or without bare metal stent implantation(BMSI)was set as the control arm.A systematic search in the Excerpta Medica Database(Embase),PubMed,Web of Science,and Cochrane Library was performed on November 29,*** controlled studies published in English with sufficient data on outcomes of interest for extraction or conversion were *** studies did not directly report the HRs but gave a corresponding survival curve,we utilized Engauge Digitizer software and standard formulas to convert the information and derive ***,meta-analyses were conducted using a random-effects *** Five randomized controlled trials and three cohort studies involving 2639 participants were *** ACDfree and MA-free survival HR values for DESI were not statistically significant from those of the control treatment(P0.05);however,the HR values for TLR-free,AE-free,and PP-survival differed significantly[2.65(95%
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