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Schistosoma haematobium and Plasmodium falciparum coinfection with protection against Plasmodium falciparum malaria in Nigerian children

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 16-20页

作者： Nmorsi OPG Isaac C Ukwandu NCD Ekundayo AO Ekozien MI Tropical Diseases Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria Department of Medical Microbiology Ambrose Alli UniversityEkpomaNigeria Department of Microbiology Ambrose Alli UniversityEkpomaNigeria

Objective:Malaria remains the single leading killer of children in sub - Sahara Africa and Schistosomiasis is considered to be second to malaria in global *** - infection of malaria and urinary schistosomiasis has been reported to exacerbate disease morbidity such as *** different part of the globe,the co - infection between malaria and schistosomiasis provides some protections on the infected *** protective effect of this co - infection elucidated immunologically using cytokines is lacking in our ***:Urine and blood samples obtained from the 160 volunteers were subjected to standard parasitological techniques for diagnosis of urinary schistosomiasis and malaria *** samples collected from these volunteers comprising 80 children with schistosomiasis and malaria and the 80 children who had malaria only were subjected to cytokines concentration determination using commercial standard enzyme linked immunosorbent assay kits(Abeam,UK).Results:Eighty participants with co - infection had a mean malarial parasitaemia of 662±201.1μL while the 80 participants with only *** malaria had a mean malarial parasiteamia of 5943±3270.7μ*** the volunteers had mean haemoglobin of 11.2 g/dL for co - infected individuals and 5.7 g/dL for participants with single infection of *** serum cytokine levels of the children with S. haematobium and *** and only *** infection are as follows;interleukin - 4(16.6 pg/ mL versus 5.2 pg/mL),IL - 5(501.3 pg/mL versus 357.5 pg/mL);IL -8(2 550 pg/mL versus 309 pg/mL),IL - 10(273 pg/mL versus 290 pg/mL),TNF -α(25 pg/mL versus 290 pg/mL) and IFN -γ(21.9 pg/mL versus 2.5 pg/mL).The TNF -α/IL - 10 ratio is 7 for the children with co - infection while those with only *** malaria infection had a TNF -α/IL - 10 ratio of ***:We conclude that the elevated IL - 4,IL - 5,IL - 8 and IFN -γconcentration induced by schistosomiasis altered the Th1/Th 2 profile a

关键词： Schistosoma haematobium Plasmodium falciparum Malaria

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Effect of pre-existing Schistosoma haematobium infection on Plasmodium berghei multiplications in imprinting control region mice

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 486-490页

作者： Benjamin Amoani Elvis Ofori Ameyaw Du-Bois Asante Francis Ackah Armah James Prah Collins Paa Kwesi Botchey Johnson Nyarko Boampong Department of Biomedical and Forensic Sciences University of Cape Coast Noguchi Memorial Institute for Medical Research University of Ghana University of Cape Coast Hospital

Objective: To investigate the effect of pre-existing Schistosoma haematobium(S. haematobium) infection on malaria disease ***: The study involved the use of twenty-i ve imprinting control region mice, i fteen of which were initially infected with S. haematobium. Five of the remaining ten schistouninfected mice together with i ve schisto-infected mice were infected with Plasmodium berghei(P. berghei) after four weeks(acute stage) of schistosoma infection. The remaining i ve schisto-uninfected mice together with i ve schisto-infected mice were also infected with P. berghei after seven weeks(chronic stage) of schistosoma infection. The last i ve schistoinfected mice were used as control group. They were then monitored for changes in P. berghei parasitaemia on Days 3, 5, 7, 9 and 11 post-infection. Records on their survivability were also ***: The co-infected mice had signii cantly higher malaria parasitaemia, compared with the mono-infected mice during acute S. haematobium infection. In contrast, the co-infected mice had signii cantly lower malaria parasitaemia during chronic S. haematobium infection and a higher survival ***: Co-infection of mice with P. berghei during acute S. haematobium infection resulted in rapid P. berghei development and increased malaria parasitaemia. However, the co-infection resulted in slower P. berghei development and decreased malaria parasitaemia with enhanced survivability of the mice during chronic S. haematobium infection. Therefore, pre-existing chronic S. haematobium infection may provide some protection to the host by reducing parasitaemia.

关键词： Schistosoma haematobium Plasmodium berghei Parasitaemia Survivability

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Performance of a real-time PCR approach for diagnosing Schistosoma haematobium infections of different intensity in urine samples from Zanzibar

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Infectious Diseases of Poverty 2020年第5期9卷 22-34页

作者： Dominique Keller Julian Rothen Jean-Pierre Dangy Corina Saner Claudia Daubenberger Fiona Allan Shaali M.Ame Said M.Ali Fatma Kabole Jan Hattendorf David Rollinson Ralf Seyfarth Stefanie Knopp Biolytix AG Benkenstrasse 2544108 WitterswilSwitzerland Swiss Tropical and Public Health Institute Socinstrasse 574002 BaselSwitzerland University of Basel Petersplatz 14001 BaselSwitzerland Wolfson Wellcome Biomedical Laboratories Department of Life SciencesNatural History MuseumCromwell RoadLondon SW75BDUK Public Health Laboratory Ivo de Carneri P.O.Box 122Chake-ChakePembaUnited Republic of Tanzania Neglected Diseases Programme Ministry of HealthP.O.Box 236Zanzibar TownUngujaUnited Republic of Tanzania

Background:Efforts to control and eliminate schistosomiasis have accelerated over the past *** parasite burden,associated morbidity and egg excretion decrease,diagnosis with standard parasitological methods becomes *** assessed the robustness and performance of a real-time PCR(qPCR)approach in comparison with urine filtration microscopy and reagent strip testing for the diagnosis of Schistosoma haematobium infections of different ***:The robustness of DNA isolation and qPCR was validated in eight laboratories from Europe and ***,792 urine samples collected during cross-sectional surveys of the Zanzibar Elimination of Schistosomiasis Transmission(ZEST)project in 2012-2017 were examined with qPCR in *** sensitivity of the qPCR was calculated at different infection intensity categories,using urine filtration microscopy as reference ***'s rank correlation between Ct-values and *** egg counts was assessed and Ct-value percentiles for infection intensity categories ***:*** Dra1 DNA-positive samples were identified correctly in all eight *** of urine samples from Zanzibar revealed Dra1 DNA in 26.8%(212/792)by qPCR,*** eggs in 13.3%(105/792)by urine filtration,and microhaematuria in 13.8%(109/792)by reagent *** of the qPCR increased with augmenting egg counts:80.6%(29/36)for counts between 1 and 4 eggs,83.3%(15/18)for counts between 5 and 9 eggs,100%(23/23)for counts between 10 and 49 eggs,and 96.4%(27/28)for counts of 50+*** was a significant negative correlation between Ct-values and egg counts(Spearman's rho=-0.49,P<0.001).Seventy-five percent of the Ct-values were≥33 in the egg-negative category,<31 in the light intensity category,and<24 in the heavy intensity ***:While the sensitiivity of the qPCR was^80%for very light intensity infections(egg counts<10),in general,the Dra1 based qPCR assay detected t

关键词： Control Diagnosis Dra 1 Elimination Microhaematuria Real-time PCR Schistosoma haematobium Surveillance Urine filtration Zanzibar

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Cancer and Infectious Causes

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Open Journal of Medical Microbiology 2014年第3期4卷 161-177页

作者： Aaron J. Smith John Oertle Dino Prato Envita Scottsdale AZ USA

Various kinds of organisms, including viruses, bacteria, trematodes and fungi are known carcinogens that cause cancer. Infectious identification related to cancer may lead to better treatment for both the prevention and targeting of cancer therapy. Although nearly 20% of all cancers are caused by an infection of a microbe, the amount of evidence and information regarding the mechanisms associated with oncogenesis varies dramatically from one organism to the next. This review cannot be exhaustive because we are not aware of all infections worldwide in addition to their potential mechanisms for oncogenesis. More research is required for all of the species mentioned in this review.

关键词： Epstein Bar Virus Hepatitis B Virus Hepatitis C Virus Human Herpes Virus 6 Human Herpes Virus 8 Human Papillomavirus Human T-Cell Leukemia Virus Type 1 Merkel Cell Polyomavirus Chlamydia pneumonia Helicobacter pylori Mycoplasma Salmonella typhi-1 Streptococcus bovis Clonorchis sinensis Opisthorchis viverrini Schistosoma haematobium Aspergillus flavus Aspergillus parasiticus Cancer Oncogenesis

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Biological and physiological parameters of <i>Bulinus truncatus</i>snails exposed to methanol extract of the plant <i>Sesbania sesban</i>plant

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Advances in Biological Chemistry 2011年第3期1卷 65-73页

作者： Wafaa Salim Hasheesh Ragaa Taha Mohamed Sayed Abd El-Monem 不详

The effects of sublethal concentrations of methanol extract of sesbania sesban plant on survival rate, egg laying of Bulinus truncatus snails, hatchability of their eggs, infection rate with Schistosoma haemato- bium miracidia, cercarial production and certain physiological parameters of treated snails were stu- died. The sublethal concentrations of the tested plant extract (LC0, LC10 and LC25) caused considerable reduction in survival rates;egg production of B. runcates snails;hatchability of eggs as well as in the infectivity of Schistosoma haematobium miracidia to the snail. Also, the tested concentrations reduced the cercarial production per snail and the period of cer-carial shedding. The glucose level in haemolymph of exposed snails was elevated while the glycogen, pro-tein content and the activities of hexokinase (HK), pyruvatekinase (PK) and lactate dehydrogenase (LDH) showed a decrease in soft tissues when compared with the control group. It was concluded that the app lication of sublethal concentration of methanol ex- tracts of Sesania sesban may be helpful in snail con- trol as it interferes with the snails’ biology and phy- siology.

关键词： Bulinus truncatus Schistosoma haematobium Miracidia Sesbania sesban Plant

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Urinary Schistosomiasis in Children—Still a Concern in Part of the Ghanaian Capital City

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Open Journal of Medical Microbiology 2013年第3期3卷 151-158页

作者： Patience B. Tetteh-Quarcoo Simon K. Attah Eric S. Donkor Marian Nyako Andrew A. Minamor Emmanuel Afutu Edward T. Hervie Patrick F. Ayeh-Kumi Department of Biochemistry Cell and Molecular Biology University of Ghana Accra Ghana Department of Medical Laboratory Sciences University of Ghana School of Allied Health Sciences Accra Ghana Department of Microbiology University of Ghana Medical School Accra Ghana Department of Science Laboratory Technology Accra Polytechnic Accra Ghana Neglected Tropical Disease Program Disease Control & Prevention Department Ghana Health Service Accra Ghana

Schistosomiasis is a parasitic disease of the tropics which is estimated to affect up to 300 million people worldwide. While it is being successfully controlled in many countries, it remains a major public health problem, especially in developing countries including Ghana. Extensive work on schistosomiasis has been undertaken along theVoltaRiverbasin, leaving very little data and information on this infection in the urban and peri-urban areas inGhana. This study was aimed at determining the urinary schistosomiasis burden among children of school going age within Zenu, a suburb of the capital city. Urine samples were taken from 274 school children within the Zenu community and examined with urine chemistry dipsticks for detection and confirmation of haematuria, followed by microscopy for detection of Schistosoma haematobium ova. Prevalence of urinary schistosomiasis was 30.7% (95% CI: 25.2-36.2). 44 (52%) of the positive samples were collected from males whiles 40 (48%) were collected from females, but prevalence of the infection was not significantly associated with gender (χ2 = 0.041, DF = 1, P-Value = 0.839). Among the S. haematobium positive children, haematuria was detected by the dipstick in 88.1% (74/84, 95% CI: 81.2- 95.0), but it was not detected in 11.9% (10/84, 95% CI: 5.0-18.8). Meanwhile, the dipstick detected haematuria in 7.3% (20/274, 95% CI: 4.3-7.3) of the total population but microscopy could not detect the presence of Schistosoma ova in those children. An association was found between Schistosoma infection and haematuria detected by dipstick (χ2 = 84.715, DF = 1,

关键词： Schistosomiasis Haematuria Schistosoma haematobium Accra

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