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hptlc-ms: an advance approach in herbal drugs using fingerprint spectra and mass spectroscopy

Traditional Medicine Research 2023年第2期8卷 21-35页

作者： Babita Sharma Atiqul Islam Alok Sharma Department of Pharmaceutical Analysis ISF College of PharmacyMoga 142001India Department of Pharmacognosy ISF College of PharmacyMoga 142001India

High-performance thin-layer chromatography-mass spectrometry(hptlc-ms)is one of the most modern hyphenated analytical methods available ***-ms has recently been used to perform extensive analytical work using advanced features and still more analyses are in progress using these advanced *** medicines contain a wide range of bioactives that require proper identification for the activity and quality ***,herbal medicine identification and quality control have become increasingly popular using high-performance liquid chromatography mass *** aim of this paper is to provide a brief overview of recent method developments in analysis,15 most significant herbal drug applications with their chromatographic conditions,pharmacological actions,and solvents used in the present *** extensive literature search was performed incorporating several databases,notably,Web of Knowledge,PubMed and Google Scholar,and other relevant published *** previous research,hptlc and its hyphenation with ms allowed for quantification of analytes in complex matrixes at nanogram and picogram *** a wide variety of analytes using these techniques has been extremely accurate,selective,and *** this review,the hptlc-ms technique is discussed in relation to the quality control of herbal ***,15 herbal drugs were identified based on their RF values and m/z ratio by mass spectrometry by hptlc-ms for the first *** this compilation,researchers can gain insights into hptlc-ms techniques for resolving quality control issues with herbal drugs using their fingerprint ***,the application of hptlc-ms methods could to be sufficiently precise and reproducible for established conditions and after validation may be used for routine quality control of herbal drugs/formulations in herbal industries.

关键词： chromatography herbal drug hptlc-ms mass spectrometry quality control

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hptlc-ms as a Neoteric Hyphenated Technique for Separation and Forensic Identification of Drugs

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Journal of Analytical Sciences, Methods and Instrumentation 2018年第1期8卷 1-15页

作者： Kanak Lata Verma Manoj Kumar Amar Pal Singh Regional Forensic Science Laboratory Government of NCT of Delhi New Delhi India Forensic Science Post Graduate Course Department of Anthropology University of Delhi New Delhi India

Drugs are traditionally been identified on basis of chromatographic-spectroscopic hyphenated techniques in instrumental analysis. Gas chromatography (GC) and Liquid chromatography (LC) hyphenated with mass spectroscopy (ms) i.e. GC-ms and LC-ms give reliable and confirmatory results in drugs identification. In the present work the novel hyphenated technique High Performance Thin Layer Chromatography-Mass Spectroscopy (hptlc-ms) has been used. This technique provides efficient, quick and simple method for identification and separation of Narcotic drugs and psychotropic substances. The drugs under study are Papaverine, Methadone, Cocaine, Ketamine, Caffeine, Codeine, Diazepam, Thebaine, Heroin, Methamphetamine, Carbamazepine, Morphine, Narcotine and Ephedrine. The present study comprising of sixteen drugs has been carried out on CAMAG hptlc instrument with automatic sampling. Thin layer chromatography (TLC) plates were developed in various solvent systems, scanned under TLC scanner and the results in terms of Retention Factor (Rf value) and UV spectrum (λmax) are presented in the manuscript. Using hyphenated technique of hptlc-ms (ms 2020 SHIMADZU) spots of these drugs from TLC plate was lifted with CAMAG TLC-ms interface and confirmed by the mass spectrum of the individual drugs by their m/z values thus delivering fast and accurate confirmatory result on the TLC plate.

关键词： Narcotic Drugs Psychotropic Substances hptlc-ms Chromatography Mass Spectroscopy Hyphenated Techniques Forensic Science

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