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Maternal organic selenium supplementation during gestation enhances muscle fiber area and muscle fiber maturation of offspring in porcine model

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Journal of Animal Science and Biotechnology 2023年第2期14卷 654-665页

作者： Yan Lin Hui Yan Lei Cao Daolin Mou Dajiang Ding Binting Qin Lianqiang Che Zhengfeng Fang Shengyu Xu Yong Zhuo Jian Li Jianping Wang Chao Huang Yuanfeng Zou Lixia Li De Wu Bin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Key Laboratory of Animal Disease‑Resistant Nutrition of Ministry of Education Sichuan Agricultural UniversityChengduChina College of Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background:Organic selenium supplementation during gestation improves the antioxidant status and reproduc-tive performance of sows and increases the antioxidative capacity of the intestines of their *** study was conducted to investigate the effect of maternal basel diet(control)supplemented with an organic Se,2-hydroxy-4-methylselenobutanoic acid(hmseba),or inorganic sodium selenite(Na_(2)SeO_(3))during gestation on the antioxidant status and development of muscle in newborn and weaned *** piglets before colostrum intake and weaned piglets were selected for longissimus dorsi(LD)muscle collection and ***:The results showed that maternal hmseba supplementation increased the muscle area and content of Se in the LD muscle of newborn piglets,improved gene expression of selenoproteins,and decreased oxidative status in the LD muscle of both newborn and weaned piglets compared with the *** expression of muscle development-related genes of newborn piglets in the hmseba group was lower than in the control group,whereas the expression of MRF4 in weaned piglets was higher in the hmseba group than in the control and Na_(2)SeO_(3)*** addition,hmseba supplementation decreased the mRNA expressions of myosin heavy chains(MyHC)IIx and MyHC IIb and the percentage of MyHC IIb;increased the expression of PGC-1αin the LD muscle of newborn piglets;increased the gene expression of MyHC IIa;and decreased the protein expression of slow MyHC and the activity of malate dehydrogenase in the LD muscle of weaned piglets compared with the control ***:Maternal hmseba supplementation during gestation can improve the antioxidative capacity of the muscle of their offspring and promote the maturity of muscle fibres in weaned offspring.

关键词： Antioxidation hmseba Muscle Offspring Sows

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Selenogenome and AMPK signal insight into the protective effect of dietary selenium on chronic heat stress-induced hepatic metabolic disorder in growing pigs

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Journal of Animal Science and Biotechnology 2022年第1期13卷 152-165页

作者： Yan Liu Jiayong Tang Ying He Gang Jia Guangmang Liu Gang Tian Xiaoling Chen Jingyi Cai Bo Kang Hua Zhao Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory for Animal Disease-Resistance Nutrition Ministry of EducationHuimin RoadWenjiang DistrictChengdu 611130SichuanChina College of Animal Science and Technology Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background:Chronic heat stress(CHS)disrupts hepatic metabolic homeostasis and jeopardizes product quality of ***(Se)may regulate the metabolic state through affect ***,we investigate the protective effect of dietary hydroxy-4-methylselenobutanoic acid(hmseba)on CHS induced hepatic metabolic disorder in growing pigs,and the corresponding response of ***:Forty crossbreed growing pigs were randomly assigned to five groups:control group raised in the thermoneutral environment(22±2℃)with basal diet;four CHS groups raised in hyperthermal condition(33±2℃)with basal diet and supplied with 0.0,0.2,0.4,and 0.6 mg Se/kg hmseba,*** trial lasted 28 *** serum biochemical,hepatic metabolism related enzyme,protein and gene expression and 25 selenoproteins in liver tissue were determined by real-time PCR,ELISA and western ***:CHS significantly increased the rectal temperature,respiration rate,serum aspartate aminotransferase(AST)and low-density lipoprotein cholesterol(LDL-C)of pigs,up-regulated hepatic heat shock protein 70(HSP70)and induced lower liver weight,glycogen content,hepatic glucokinase and glutathione peroxidase(GSH-Px).The CHSinduced liver metabolic disorder was associated with the aberrant expression of 6 metabolism-related gene and 11 selenoprotein encoding genes,and decreased the protein abundance of GCK,GPX4 and *** improved anti-oxidative capacity of liver.0.4 or 0.6 mg Se/kg hmseba supplementation recovered the liver weight,glycogen content and rescue of mRNA abundance of genes related to metabolism and protein levels of *** supplementation changed expressions of 15 selenoprotein encoding genes,and enhanced protein expression of GPX1,GPX4 and SELENOS in the liver affected by *** alone showed no impact while hmseba supplementation increased protein levels of p-AMPKαin the ***:In summary,hmseba supplementation beyond nutrient requirement mitigates CHS-induced hepati

关键词： Chronic heat stress Hepatic metabolism hmseba Pigs Selenoprotein

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维普期刊数据库

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不同硒源在产蛋鸡上的评价

不同硒源在产蛋鸡上的评价

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作者：孙庆艳中国农业科学院

学位级别：硕士

本试验在消除蛋鸡品种、日龄、营养水平等差异的情况下,研究硒代蛋氨酸羟基类似物(2-hydroxy-4-methylselenobutanoic acid,hmseba)、酵母硒(Yeast Selenium,YSe)、蛋氨酸硒(Selenomethionine,MetSe)、纳米硒(Nano-selenium,NSe)和亚硒酸钠(Sodium selenite,NaSe)对蛋鸡生产性能、蛋品质、血浆抗氧化能力和鸡蛋硒含量的影响。试验一饲粮中添加不同硒源对产蛋鸡生产性能和抗氧化能力的影响试验研究了饲粮中添加NaSe、hmseba、YSe、MetSe和NSe对产蛋鸡生产性能、蛋品质、血浆抗氧化能力和鸡蛋硒含量的影响,旨在为蛋鸡饲粮中硒的合理使用提供依据。选取18 WK健康、产蛋率相近的海兰灰蛋鸡648只,随机分为6组,每组6个重复,每个重复18只。对照组饲喂不添加硒的基础饲粮(总硒0.08 mg/kg),其他5组添加0.30 mg/kg硒,分别来自NaSe、hmseba、YSe、MetSe和NSe(实测硒分别为:0.37、0.37、0.38、0.34和0.41 mg/kg)。预试期1周,正试期8周。结果表明:1)不同硒源对蛋鸡的生产性能和蛋品质均无显著影响(P>0.05)。2)与对照组相比,饲粮中添加0.30 mg/kg的5种硒源均提高了血浆总超氧化物歧化酶(T-SOD)活力。4周末时,hmseba和YSe组T-SOD显著高于对照组(P0.05)。与对照组相比,饲粮中添加不同硒源均降低了血浆丙二醛(MDA)含量。4周末时,各组间MDA差异不显著(P>0.05);8周末时,hmseba和MetSe组MDA含量显著低于对照组(Phmseba组显著高于其他3组(Phmseba能更有效增加鸡蛋硒含量。试验二酵母硒对产蛋鸡的耐受性评价本试验旨在研究饲粮中添加不同水平酵母硒(YSe)对产蛋鸡生产性能、蛋品质、血液生化指标和蛋硒含量的影响。选取576只21 WK的健康海兰褐产蛋鸡,随机分为6处理,每处理6个重复,每个重复16只鸡。YSe0为对照组,饲喂基础饲粮,YSe.3、YSe.6、YSe.9、YSe3和Yse15组分别饲喂含硒0.30、0.60、0.90、3.0和15.0 mg/kg(来自YSe)的饲粮。预试期1周,正试期8周。结果表明:1)与对照组相比,YSe.9组产蛋率显著提高(P0.05)。2)饲粮中添加YSe显著影响蛋壳厚度、蛋黄颜色、蛋壳比例(P0.05)。3)饲粮中添加不同水平的YSe对红细胞数、血小板计数、红细胞压积和血红蛋白无显著影响(P>0.05);8周末时,YSe.3组的白细胞数显著低于除YSe.6组外的其他各组(P0.05);8周末时,YSe15组显著高于YSe.3组(P0.05)。5)饲粮中添加YSe能有效提高鸡蛋中硒含量(P<0.05),且随饲粮硒含量的升高线性升高(R2=0.9790)。由此可见,饲粮中添加YSe能改善产蛋鸡的生产性能和蛋品质,有效提高蛋硒含量。但过高的硒(15.0 mg/kg)引起了采食量、体重下降,肝脏转氨酶升高,不利于机体健康。因此建议开产期海兰褐产蛋鸡饲粮硒(来自YSe)添加量应低于15.0 mg/kg。试验三硒代

关键词：产蛋鸡硒源酵母硒 hmseba 生产性能抗氧化能力耐受性蛋硒含量

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