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Recombinant hiv to kill latent reservoir cells: a hypothetical therapeutic strategy

Medical Theory and Hypothesis 2022年第4期5卷 32-38页

作者： Umesh Chandra Hader Department of Zoology Raniganj Girls’CollegeSearsole-RajbariPaschim BardhamanRaniganj 713358West BengalIndia.

latency is the pivotal factor that governs the long-term pathogenecity and persistence of hiv-1 *** is also the primary impediment to cure and successful treatment,resulting in patient *** of hiv-1 infection promotes failure of the conventional antiretroviral therapy(ART).Cessation of ART immediately leads to viral reactivation and attainment of viral load in peripheral *** comes with severe side effects and is ineffective at treating latent *** eliminate latent infection,alternate therapeutic strategies such as Shock and Kill,Block and Lock,gene editing and vaccination have been *** these strategies have experimentally been proven successful,they possess major ***,in this hypothesis,an alternate therapeutic strategy has been proposed to solve the threat of *** proposed model encompasses the generation and administration of recombinant hiv-1 particles whose genomes having pro-apoptotic gene,tBid,will activate apoptotic cell death pathways after infecting only the latent cells,thereby removing latent hiv host cells from patients’bodies.

关键词： hiv latency recombinant hiv tBid homologous recombination antiretroviral therapy lentiviral vectors

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Moving Toward a Functional Cure for hiv-1

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Infectious Diseases & Immunity 2021年第3期1卷 161-168页

作者： Wen Kang Yongtao Sun Department of Infectious Diseases Tangdu HospitalThe Fourth Military Medical UniversityXi’an 710038China

Despite the recent success of suppressing human immunodeficiency virus 1(hiv-1)replication in the peripheral blood with antiretroviral therapy,elimination of the provirus from infected cells remains challenging because the virus can integrate into the host genome and become a latent proviral *** removal of these latent viral reservoirs from tissue containing infected resting memory CD4+T cells remains a major barrier to developing a cure for *** novel strategies have recently been developed for curing hiv *** include stem cell transplantation with CCR5-D32 mutated cells,initial antiretroviral treatment in the very early stage of hiv infection,gene editing to excise the hiv genome or generate CCR5-mutated hiv-1-resistant cells,“shock-and-kill”to reactivate latent hiv using latency reversal agents combined with enhanced immune clearance methods,and an emerging“block-and-lock”strategy to reactivate latent hiv using latency reversal agents combined with enhanced immune clearance ***,the high risks and limitations to scale-up in clinics,as well as poor performance in clinical trials,have hampered these *** review aims to describe the present efforts that are being made to combat hiv latency,and critically discuss the limitations and future of the cure for hiv-1.

关键词： hiv Block-and-lock Deep latency hiv latency Shock-and-kill Transcriptional reactivation

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