Recombinant HIV to kill latent reservoir cells: a hypothetical therapeutic strategy

作     者：Umesh Chandra Hader 

作者机构：Department of ZoologyRaniganj Girls’CollegeSearsole-RajbariPaschim BardhamanRaniganj 713358West BengalIndia. 

出 版 物：《Medical Theory and Hypothesis》 (医学理论与假说)

年 卷 期：2022年第5卷第4期

页      面：32-38页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：HIV latency recombinant HIV tBid homologous recombination antiretroviral therapy lentiviral vectors 

摘      要：Latency is the pivotal factor that governs the long-term pathogenecity and persistence of HIV-1 *** is also the primary impediment to cure and successful treatment,resulting in patient *** of HIV-1 infection promotes failure of the conventional antiretroviral therapy(ART).Cessation of ART immediately leads to viral reactivation and attainment of viral load in peripheral *** comes with severe side effects and is ineffective at treating latent *** eliminate latent infection,alternate therapeutic strategies such as Shock and Kill,Block and Lock,gene editing and vaccination have been *** these strategies have experimentally been proven successful,they possess major ***,in this hypothesis,an alternate therapeutic strategy has been proposed to solve the threat of *** proposed model encompasses the generation and administration of recombinant HIV-1 particles whose genomes having pro-apoptotic gene,tBid,will activate apoptotic cell death pathways after infecting only the latent cells,thereby removing latent HIV host cells from patients’bodies.