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A mitochondria-targeted h_(2)s-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury

Chinese Chemical Letters 2024年第6期35卷 370-375页

作者： Bin Fang Jiaqi Yang Limin Wang haoqin Li Jiaying Guo Jiaxin Zhang Qingyuan Guo Bo Peng Kedi Liu Miaomiao Xi hua Bai Li Fu Lin Li school of Materials science and Engineering Northwestern Polytechnical UniversityXi’an 710072China Frontiers science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and TechnologyWuhan 430074China TANK Medicinal Biology Institute of Xi’an Xi’an 710032China

hepatic ischemia-reperfusion injury(hIRI)is the cause of postoperative hepatic dysfunction and failure,and even *** an important biological effector molecule,hydrogen sulfide(h_(2)s)of mitochondria as a gasotransmitter that is usually used to protect against acute hIRI ***,the exact relationship between hIRI and mitochondrial h_(2)s remains tangled due to the lack of an effective analytical ***,we have fabricated a mitochondria-targeted h_(2)s-activatable fluorogenic probe(Mito-GW)to explore the stability of mitochondrial h_(2)s and track the changes of mitochondrial h_(2)s during the *** virtue of pyridinium electropositivity and its amphiphilicity,Mito-GW could accumulate in *** goes through an analyte-prompted immolation when reacts with h_(2)s,resulting in the releasing of the fluorophore(GW).Therefore,the extent of Mito-GW conversion to GW can be used to evaluate the changes of mitochondrial h_(2)s level in living cells and *** proof-of-principle,we have used MitoGW to demonstrate the mitochondria h_(2)s-levels increase and then decrease during hIRI in vitro and in *** research highlights the tremendous potential of Mito-GW as a mitochondrial h_(2)s fluorogenic probe in elucidating the pathogenesis of hIRI,providing a powerful tool for promoting future research on hepatology.

关键词： Mitochondria-targeted Bioimaging h2s-activatable Fluorogenic probe hepatic ischemia-reperfusion injury(hIRI)

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