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gymnema montanum improves endothelial function via inhibition of endoplasmic reticulum stress by activating Nrf2 signaling

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Asian Pacific Journal of Tropical Biomedicine 2020年第8期10卷 379-386页

作者： Dornadula Sireesh Natarajan Suganya Suvro Chatterjee Kunka Mohanram Ramkumar SRM Research Institute SRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia Vascular Biology Lab AU-KBC Research CentreAnna UniversityChromepetChennai-600044Tamil NaduIndia

Objective:To investigate the effects of gymnema montanum leaf extract against endoplasmic reticulum(ER)stress-induced toxicity in endothelial ***:The immortalized endothelial hybrid cell,***926 was treated with different concentrations of gymnema montanum leaf extract(0–100μg/mL)and the ER stress inducer,*** cytotoxicity was assessed by MTT as well as lactate dehydrogenase and malondialdehyde levels were *** levels of ER stress markers,GRP78 and CHOP were analysed by Western blot *** gymnema montanum leaf extract-mediated activation of nuclear factor erythroid 2-related factor 2(Nrf2)was assessed by cell-based luciferase enzyme fragment complementation assay and antioxidant responsive element driven luciferase reporter *** levels of phosphoproteins of the MAPK pathway were analyzed using the Bioplex ***:A dose-dependent cytoprotective effect of gymnema montanum leaf extract was observed in tunicamycin-induced *** montanum leaf extract significantly reduced lactate dehydrogenase activity and malondialdehyde levels in ER stress-induced endothelial *** also suppressed ER stress markers dose dependently and inhibited the phosphorylation of JNK,ERK,MEK and p38 MAPK in tunicamycin-induced endothelial ***,gymnema montanum leaf extract increased the expression of Nrf2 and its downstream targets in endothelial ***:gymnema montanum leaf extract attenuates ER stress by increasing the expression of Nrf2 and its downstream genes.

关键词： ER stress gymnema montanum Nrf2 Endothelial cells

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