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Journal of Environmental Sciences 2024年第3期137卷 120-130页

作者： Sen Yan Wei Sun Sinuo Tian Zhiyuan Meng Jinling Diao Zhiqiang Zhou Li Li Wentao Zhu Innovation Center of Pesticide Research Department of Applied ChemistryCollege of ScienceChina Agricultural UniversityBeijing 100193China College of Plant Protection/Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009China College of Plant Protection Shanxi Agricultural UniversityTaiyuan 030031China

Several studies have confirmed that the health status of the paternal affects the health of the offspring,however,it remains unknown whether paternal exposure to pesticides affect the offspring health.Here,we used untargeted metabolomics and 16S rRNA sequencing technology,combined with tail suspension test and RT-qPCR to explore the effects of paternal exposure to nitenpyram on the neurotoxicity of offspring.Our results found that the paternal exposure to nitenpyram led to the offspring’s depressive-like behaviors,accompanied by the reduction of tryptophan content and the disorder of microbial abundance in the gut of the offspring.Further,we determined the expression of tryptophan metabolism-related genes tryptophanase(tnaA)and tryptophan hydroxylase 1(TpH1)in gut bacteria and colonic tissues.We found that tryptophan is metabolized to indoles rather than being absorbed into colonocytes,which coursed the reduce of tryptophan availability after nitenpyram exposure.In conclusion,our study deepens our understanding of the intergenerational toxic effects of pesticides.

关键词： Nitenpyram Depressive-like behaviors Gut microbiota Tryptophan metabolism

Unlocking a novel determinant of athletic performance:The role of the Gut microbiota,short-chain fatty acids,and“biotics”in exercise

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Journal of Sport and Health Science 2023年第1期12卷 36-44页

作者： Kate M.Sales Raylene A.Reimer Faculty of Kinesiology University of CalgaryCalgaryAB T2N 1N4Canada Department of Biochemistry&Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4N1Canada

The Gut microbiota refers to the collection of trillions of intestinal microorganisms that modulate central aspects of health and disease through influential effects on host physiology.Recently,a connection has been made between the Gut microbiota and exercise.Initial investigations demonstrated the beneficial effects of exercise on the Gut microbiota,with cross-sectional studies revealing positive correlations between exerciseassociated states,and healthy Gut microbiota and exercise interventions showed post-intervention increases in the abundance of beneficial bacterial taxa.More recent investigations have focused on exploring the reverse relationship:the influence of the Gut microbiota on exercise performance.Murine investigations have revealed that certain bacterial taxa may enhance endurance exercise performance by augmenting various aspects of lactate metabolism.Further,short-chain fatty acids—which modulate metabolism at various organ sites,including within skeletal muscle—have been shown to enhance endurance exercise capacity in mice.This review highlights what is currently known about the connection between the Gut microbiota and exercise,with a particular focus on the ergogenic potential of the Gut microbiota and how it may be leveraged to enhance endurance exercise performance.

关键词： Exercise performance Gut microbiota Short-chain fatty acids

Impacts of pancreatic exocrine insufficiency on Gut microbiota

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin GUO Feng CAO Fei LI Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical University Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and post-pancreatectomy.The main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion feedback.Animal studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement therapy.Clinical studies have also confirmed the association between PEI and the dysbiosis of Gut microbiota.Pancreatic exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of Gut microbiota.In turn,the Gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional crosstalk.Going forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the Gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota gut microbiome Pancreatic enzyme replacement therapy

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression-and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4801-4822页

作者： Kaikai Zhang Lijian Chen Jianzheng Yang Jiali Liu Jiahao Li Yi Liu Xiuwen Li Long Chen Clare Hsu Jiahao Zeng Xiaoli Xie Qi Wang Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhou 510515China Department of Toxicology School of Public HealthSouthern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease Research)Guangzhou 510515China

Methamphetamine(Meth)abuse can cause serious mental disorders,including anxiety and depression.The Gut microbiota is a crucial contributor to maintaining host mental health.Here,we aim to investigate if microbiota participate in Meth-induced mental disorders,and the potential mechanisms involved.Here,15 mg/kg Meth resulted in anxiety-and depression-like behaviors of mice successfully and suppressed the Sigma-1 receptor(SIGMAR1)/BDNF/TRKB pathway in the hippocampus.Mean-while,Meth impaired gut homeostasis by arousing the Toll-like receptor 4(TLR4)-related colonic inflammation,disturbing the gut microbiome and reducing the microbiota-derived short-chain fatty acids(SCFAs).Moreover,fecal microbiota from Meth-administrated mice mediated the colonic inflam-mation and reproduced anxiety-and depression-like behaviors in recipients.Further,SCFAs supple-mentation optimized Meth-induced microbial dysbiosis,ameliorated colonic inflammation,and repressed anxiety-and depression-like behaviors.Finally,Sigmarl knockout(Sigmar1^(-/-))repressed the BDNF/TRKB pathway and produced similar behavioral phenotypes with Meth exposure,and elim-inated the anti-anxiety and-depression effects of SCFAs.The activation of SIGMAR1 with fluvoxamine attenuated Meth-induced anxiety-and depression-like behaviors.Our findings indicated that Gut microbiota-derived SCFAs could optimize gut homeostasis,and ameliorate Meth-induced mental disorders in a SIGMAR1-dependent manner.This study confirms the crucial role of microbiota in Methrelated mental disorders and provides a potential preemptive therapy.

关键词： Methamphetamine Gut microbiota Short-chain fatty acids Sigma-1 receptor Mental disorders Colonic inflammation Intestinal barrier gut-brain axis

Integrated analysis of miRNA and mRNA expression profiles in response to Gut microbiota depletion in the abdomens of female Bactrocera dorsalis

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Insect Science 2023年第2期30卷 443-458页

作者： JunfeiXie Zhaohui Cai Wenping Zheng Hongyu Zhang Key Laboratory of Horticultural Plant Biology(MOE) Hubei Hongshan LaboratoryChina-Australia Joint Research Centre for Horticultural and Urban PestsInstitute of Urban and Horticultural EntomologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan430070China

Insect Gut microbiota has been reported to participate in regulating host multiple biological processes including metabolism and reproduction.However,the corresponding molecular mechanisms remain largely unknown.Recent studies suggest that microRNAs(miRNAs)are involved in complex interactions between the Gut microbiota and the host.Here,we used next-generation sequencing technology to characterize miRNA and mRNA expression profiles and construct the miRNA–gene regulatory network in response to Gut microbiota depletion in the abdomens of female Bactrocera dorsalis.A total of 3016 differentially expressed genes(DEGs)and 18 differentially expressed miRNAs(DEMs)were identified.Based on the integrated analysis of miRNA and mRNA sequencing data,229 negatively correlated miRNA-gene pairs were identified from the miRNA-mRNA network.Gene ontology enrichment analysis indicated that DEMs could target several genes involved in the metabolic process,oxidation-reduction process,oogenesis,and insulin signaling pathway.Finally,real-time quantitative polymerase chain reaction further verified the accuracy of RNA sequencing results.In conclusion,our study provides the profiles of miRNA and mRNA expressions under antibiotics treatment and provides an insight into the roles of miRNAs and their target genes in the interaction between the Gut microbiota and its host.

关键词： Bactrocera dorsalis Gut microbiota microRNA-mRNA regulatory pathways

Targeting the blood-brain barrier to delay aging-accompanied neurological diseases by modulating Gut microbiota,circadian rhythms,and their interplays

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4667-4687页

作者： Yanping Wang Weihong Du Xiaoyan Hu Xin Yu Chun Guo Xinchun Jin Wei Wang Department of Neurology the Second Affliated Hospital of Jiaxing CityJiaxing 314000China Beijing Key Laboratory of Cancer Invasion and Metastasis Research Department of Histology and EmbryologySchool of Basic Medical SciencesAdvanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100069China Bengbu Medical College(Department of Neurology the Second Hospital of Jiaxing City)Jiaxing 233030China School of Biosciences University of SheffieldSheffeld S102TNUK Department of Physiology and Pathophysiology Capital Medical UniversityBeijing 100069China

AbstracTthe blood-brain barrier(BBB)impairment plays a crucial role in the pathological processes of aging-accompanied neurological diseases(AAND).Meanwhile,circadian rhythms disruption and Gut microbiota dysbiosis are associated with increased morbidity of neurological diseases in the accelerated aging population.Importantly,circadian rhythms disruption and Gut microbiota dysbiosis are also known to induce the generation of toxic metabolites and pro-inflammatory cytokines,resulting in disruption of BBB integrity.Collectively,this provides a new perspective for exploring the relationship among circadian rhythms,gut microbes,and the BBB in aging-accompanied neurological diseases.In this review,we focus on recent advances in the interplay between circadian rhythm disturbances and Gut microbiota dysbiosis,and their potential roles in the BBB disruption that occurs in AAND.Based on existing literature,we discuss and propose potential mechanisms underlying BBB damage induced by dysregulated circadian rhythms and Gut microbiota,which would serve as the basis for developing potential interventions to protect the BBB in the aging population through targeting the BBB by exploiting its links with Gut microbiota and circadian rhythms for treating AAND.

关键词： Blood-brain barrier Neurological diseases Aging Gut microbiota Circadian rhythms

Effects of iodoacetic acid drinking water disinfection byproduct on the Gut microbiota and its metabolism in rats

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Journal of Environmental Sciences 2022年第7期34卷 91-104页

作者： Yujie Sha Huan Wu Yue Guo Xi Liu Yan Mo Qiyuan Yang Shumao Wei Kunling Long Du Lu Ying Xia Weiwei Zheng Zhiheng Su Xiao Wei Department of Occupational and Environmental Health School of Public HealthGuangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation Pharmaceutical CollegeGuangxi Medical UniversityNanning 530021China Key Laboratory of the Public Health Safety Ministry of EducationDepartment of Environmental HealthSchool of Public HealthFudan UniversityShanghai 200032China Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021China Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases School of Public HealthGuangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021China

Iodoacetic acid(IAA) is an unregulated disinfection byproduct in drinking water and has been shown to exert cytotoxicity, genotoxicity, tumorigenicity, and reproductive and developmental toxicity. However, the effects of IAA on Gut microbiota and its metabolism are still unknown, especially the association between Gut microbiota and the metabolism and toxicity of IAA. In this study, female and male Sprague–Dawley rats were exposed to IAA at 0 and 16 mg/kg bw/day daily for 8 weeks by oral gavage. Results of 16S r RNA gene sequencing showed that IAA could alter the diversity, relative abundance and function of Gut microbiota in female and male rats. IAA also increased the abundance of genes related to steroid hormone biosynthesis in the Gut microbiota of male rats. Moreover, metabolomics profiling revealed that IAA could significantly disturb 6 and 13 metabolites in the feces of female and male rats, respectively. In female rats, the level of androstanediol increased in the IAA treatment group. These results were consistent with our previous findings, where IAA was identified as an androgen disruptor. Additionally, the perturbed Gut microbiota and altered metabolites were correlated with each other. The results of this study indicated that IAA could disturb Gut microbiota and its metabolism. These changes in Gut microbiota and its metabolism were associated with the reproductive and developmental toxicity of IAA.

关键词： Iodoacetic acid Drinking water Disinfection byproducts Gut microbiota Metabolomics

“Sentinel or accomplice”:Gut microbiota and microglia crosstalk in disorders of gut-brain interaction

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Protein & Cell 2023年第10期14卷 726-742页

作者： Haonan Zheng Cunzheng Zhang Jindong Zhang Liping Duan Department of Gastroenterology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases Beijing 100191China

Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction(DGBI),in which the intestinal microbiota plays an important role.Microglia are the“sentinels”of the central nervous system(CNS),which participate in tissue damage caused by traumatic brain injury,resist central infection and participate in neurogenesis,and are involved in the occurrence of various neurological diseases.With in-depth research on DGBI,we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI,especially in individuals with comorbidities of mental disorders,such as irritable bowel syndrome(IBS).This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI.In this review,we focus on the role and underlying mechanism of the interaction between Gut microbiota and microglia in DGBI,especially IBS,and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities.

关键词： Gut microbiota microglia disorders of gut-brain interaction irritable bowel syndrome

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut microbiota for Promoting Health

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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG Yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that Gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of Gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by Gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides Gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

Multi‑omics analysis reveals Gut microbiota‑ovary axis contributed to the follicular development difference between Meishan and Landrace×Yorkshire sows

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畜牧与生物技术杂志:英文版 2023年第5期14卷 1954-1968页

作者： Baoyang Xu Wenxia Qin Yuwen Chen Yimei Tang Shuyi Zhou Juncheng Huang Libao Ma Xianghua Yan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070HubeiChina Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Wuhan 430070HubeiChina

Background The mechanism by which Meishan(MS)sows are superior to white crossbred sows in ovarian follicle development remains unclear.Given Gut microbiota could regulate female ovarian function and reproductive capacity,this study aimed to determine the role of Gut microbiota-ovary axis on follicular development in sows.Methods We compared the ovarian follicular development,Gut microbiota,plasma metabolome,and follicular fluid metabolome between MS and Landrace×Yorkshire(L×Y)sows.A H_(2)O_(2)-induced cell apoptosis model was used to evaluate the effects of multi-omics identified metabolites on the apoptosis of porcine ovarian granulosa cells in vitro.Results Compared with L×Y sows,MS sows have greater ovary weight and improved follicular development,including the greater counts of large follicles of diameter≥5 mm,secondary follicles,and antral follicles,but lesser atretic follicles.The ovarian granulosa cells in MS sows had alleviated apoptosis,which was indicated by the increased BCL-2,decreased caspases-3,and decreased cleaved caspases-3 than in L×Y sows.The ovarian follicular fluid of MS sows had higher concentrations of estradiol,progesterone,follicle-stimulating hormone,luteinizing hormone,and insulin like growth factor 1 than L×Y sows.Gut microbiota of MS sows formed a distinct cluster and had improved alpha diversity,including increased Shannon and decreased Simpson than those of L×Y sows.Corresponding to the enhanced function of carbohydrate metabolism and elevated short-chain fatty acids(SCFAs)in feces,the differential metabolites in plasma between MS and L×Y sows are also mainly enriched in pathways of fatty acid metabolism.There were significant correlations among SCFAs with follicular development,ovarian granulosa cells apoptosis,and follicular fluid hormones,respectively.Noteworthily,compared with L×Y sows,MS sows had higher follicular fluid SCFAs concentrations which could ameliorate H_(2)O_(2)-induced porcine granulosa cells apoptosis in vitro.Conclusion MS sows have more secondary and antral foll

关键词： Follicular development Granulosa cells apoptosis Gut microbiota Short-chain fatty acids Sows