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Effects of granule dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats

World Journal of Gastroenterology 2022年第32期28卷 4668-4679页

作者： Yue Wu Yu Li Xiao-Ming Jin Guan-Hai Dai Xuan Chen Ye-Ling Tong Ze-Ming Ren Yu Chen Xiao-MinXue Ren-Zhao Wu First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310052Zhejiang ProvinceChina Institute of Basic Medicine Zhejiang Academy of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina College of Basic Medicine Zhejiang Chinese Medical UniversityHangzhou 310052Zhejiang ProvinceChina Stark Neuroscience Research Institute&Department of Anatomy Cell Biology and PhysiologyIndiana University School of MedicineIndianapolisIN 46202United States Department of Experimental Animals Zhejiang Academy of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina

BACKGROUND Dendrobium officinale is an herb of Traditional Chinese Medicine(TCM)commonly used for treating stomach *** formula of granule dendrobii(GD)consists of Dendrobium officinale and American Ginseng(Radix Panacis quinquefolii),and is a potent TCM product in *** treatment with GD can promote gastric acid secretion and alleviate gastric gland atrophy in chronic atrophic gastritis(CAG)requires *** To determine the effect of GD treatment on CAG and its potential cellular *** A CAG model was induced by feeding rats N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)for 12 *** oral administration of low,moderate,and high doses of GD in CAG rats for 8 wk,its effects on body weight,gastric mucosa histology,mucosal atrophy,intestinal metaplasia,immunohistochemical staining of proliferating cell nuclear antigen(PCNA)and B-cell lymphoma-2,and hemoglobin and red blood cells were *** The body weights of MNNG-induced CAG model rats before treatment(143.5±14.26 g)were significantly lower than that of healthy rats(220.2±31.20 g,P<0.01).At the 8th week of treatment,the body weights of rats in the low-,moderate-,and high-dose groups of GD(220.1±36.62 g)were significantly higher than those in the untreated group(173.3±28.09 g,all P<0.01).The level of inflammation in gastric tissue of the high-dose group(1.68±0.54)was significantly reduced(P<0.01)compared with that of the untreated group(3.00±0.00,P<0.05).The number and thickness of gastric glands in the high-dose group(31.50±6.07/mm,306.4±49.32μm)were significantly higher than those in the untreated group(26.86±6.41/mm,244.3±51.82μm,respectively,P<0.01 and P<0.05),indicating improved atrophy of gastric *** areas of intestinal metaplasia were significantly lower in the high-dose group(1.74%±1.13%),medium-dose group(1.81%±0.66%)and low-dose group(2.36%±1.08%)than in the untreated group(3.91%±0.96%,all P<0.01).The expression of PCNA in high-dose group was significantly

关键词： Chronic atrophic gastritis granule dendrobii N-methyl-N'-nitro-N-nitrosoguanidine Intestinal metaplasia

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