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Multiphasic bone-ligament-bone integrated scaffold enhances ligamentization and graft-bone integration after anterior cruciate ligament reconstruction

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Bioactive Materials 2024年第1期31卷 178-191页

作者： Xianrui Xie Jiangyu Cai Dan Li Yujie Chen Chunhua Wang Guige Hou Thorsten Steinberg Bernd Rolauffs Mohamed EL-Newehy Hany EL-Hamshary Jia Jiang Xiumei Mo Jinzhong Zhao Jinglei Wu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai201620PR China Department of Sports Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China School of Pharmacy Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of ChinaBinzhou Medical UniversityYantai264003China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou215123China Division of Oral Biotechnology Center for Dental MedicineMedical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgHugstetter Str.5579106FreiburgGermany G.E.R.N.Research Center for Tissue Replacement Regeneration&NeogenesisDepartment of Orthopedics and Trauma SurgeryFaculty of MedicineMedical Center-Albert-Ludwigs-University of Freiburg79085Freiburg im BreisgauGermany Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

The escalating prevalence of anterior cruciate ligament(ACL)injuries in sports necessitates innovative strategies for ACL *** this study,we propose a multiphasic bone-ligament-bone(BLB)integrated scaffold as a potential *** BLB scaffold comprised two polylactic acid(PLA)/deferoxamine(DFO)@mesoporous hydroxyapatite(MHA)thermally induced phase separation(TIPS)scaffolds bridged by silk fibroin(SF)/connective tissue growth factor(CTGF)@Poly(L-lactide-co-ε-caprolactone)(PLCL)nanofiber yarn braided *** combination mimics the native architecture of the ACL *** mechanical properties of the BLB scaffolds were determined to be compatible with the human *** vitro experiments demonstrated that CTGF induced the expression of ligament-related genes,while TIPS scaffolds loaded with MHA and DFO enhanced the osteogenic-related gene expression of bone marrow stem cells(BMSCs)and promoted the migration and tubular formation of human umbilical vein endothelial cells(HUVECs).In rabbit models,the BLB scaffold efficiently facilitated ligamentization and graft-bone integration processes by providing bioactive *** double delivery of DFO and calcium ions by the BLB scaffold synergistically promoted bone regeneration,while CTGF improved collagen formation and ligament ***,the findings indicate that the BLB scaffold exhibits substantial promise for ACL *** investigation and advancement of this scaffold may yield enhanced results in the management of ACL injuries.

关键词： Electrospun Thermally induced phase separation Integrated scaffold Anterior cruciate ligament reconstruction graft-bone integration

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Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction

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Bioactive Materials 2021年第3期6卷 783-793页

作者： Jiangyu Cai Qianqian Zhang Jiebo Chen Jia Jiang Xiumei Mo Chuanglong He Jinzhong Zhao Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200233China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China

It is a big challenge to develop a polyethylene terephthalate(PET)artificial ligament with excellent osteogenetic activity to enhance graft-bone integration for ligament ***,we evaluated the effect of biomineralization(BM)and electrodeposition(ED)method for depositing calcium-phosphate(CaP)on the PET artificial ligament in vitro and in *** electron microscopy and energy-dispersive X-Ray spectrometer mapping analysis revealed that the ED-CaP had more uniform particles and element distribution(Ca,P and O),and thermogravimetric analysis showed there were more CaP on the PET/ED-CaP than the PET/BM-CaP ***,the hydrophilicity of PET scaffolds was significantly improved after CaP *** vitro study showed that CaP coating via BM or ED method could improve the attachment and proliferation of MC3T3-E1 cells,and ED-CaP coating significantly increased osteogenic differentiation of the cells,in which the Wnt/β-catenin signaling pathway might be *** addition,radiological,histological and immunohistochemical results of in vivo study in a rabbit anterior cruciate ligament(ACL)reconstruction model demonstrated that the PET/BM-CaP and PET/ED-CaP scaffolds significantly improved graft-bone integration process compared to the PET *** importantly,larger areas of new bone ingrowth and the formation of fibrocartilage tissue were observed at 12 weeks in the PET/ED-CaP group,and the biomechanical tests showed increased ultimate failure load and stiffness in PET/ED-CaP group compared to PET/BM-CaP and PET ***,ED of CaP is an effective strategy for the modification of PET artificial ligament and can enhance graft-bone integration both in vitro and in vivo.

关键词： Electrodeposition Calcium-phosphate graft-bone integration Polyethylene terephthalate Artificial ligament

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