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Facile synthesis of Er^(3+)/Tm^(3+)co-doped magnetic/luminescent nanosystems for possible bioimaging and therapy applications

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Journal of Rare Earths 2022年第1期40卷 11-19页

作者： Hongyu Liu Jiabei Li Pengfei Hu Songqiang Sun Liyi Shi Lining Sun Research Center of Nano Science and Technology College of SciencesShanghai UniversityShanghai 200444China Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Instrumental Analysis&Research Center Shanghai UniversityShanghai 200444China

Manganese-zinc ferrite is a kind of very important magnetic ferrite *** properties of wide absorption band,sensitivity to ultraviolet(UV)light and tumor H_(2)O_(2) promise it to be possibly used as a photothermal therapy(PTT),photodynamic therapy(PDT)and chemodynamic therapy(CDT)*** on the unique advantages of rare-earth doped nanoparticles,an Er^(3+),Tm^(3+)co-doped upconversion-mediated nanosystem with manganese-zinc ferrite shell(named as UCNPS@M)was developed through a facile thermal co-decomposition *** final nanosystems were surface-modified by using dopamine hydrochloride(DA)in order to warrant good biocompatibility(named as UCNPS@M@DA).Under irradiation of near-infrared(NIR)light,UCNPS emit both ultraviolet and visible *** UV light is mostly abso rbed by manga nese-zinc ferrite shell to produce reactive oxygen species(ROS),which is essential to the potential PDT and CDT effect of nanosystems,and at the same time,Mn_(0.5)Zn_(0.5)Fe2O_(4) can further react with H_(2)O_(2) to promote the efficiency of *** is expected that UCNPS@M@DA can act as upconversion luminescence imaging guidance due to the visible emission from *** addition,the energy absorbed by the nanosystems can be transferred to heat to realize photothermal ***,UCNPS@M@DA was successfully applied as a T_(1)/T_(2)-weighted magnetic resonance imaging(MRI)contrast agent due to the existence of Gd,Mn,and Fe *** light of the upconversion luminescence(UCL)imaging from the UCNPS as well as potential PTT,PDT,CDT effect mentioned above,this work provides a possibility to realize cancer multi-model bioimaging guided treatment by using an all-in-one diagnosis and therapy nanosystem through a simple yet powerful strategy.

关键词： Manganese-zinc ferrite Upconversion nanoparticles Photothermal effect Reactive oxygen species good biocompatibility Rare earths

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Photothermally Enhanced Dual Enzyme-mimic Activity of Gold-Palladium Hybrid Nanozyme for Cancer Therapy

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Chinese Journal of Chemistry 2023年第23期41卷 3189-3196页

作者： Yan Kang Chao Li Huali Shi Amin Zhang Chusen Huang Chaohui Zhou Nengqin Jia The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource ChemistryShanghai Key Laboratory of Rare Earth Functional MaterialsCollege of Chemistry and Materials ScienceShanghai Normal University100 Guilin RDShanghai200234 China Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong University800 Dongchuan RDShanghai200240 China

Based on characteristics of the tumor microenvironment(TME),including acidity,hypoxia,inflammation and hydrogen peroxide overload,combined with emerging nanotechnologies,designing nanoplatforms with TME specificity/responsiveness for tumor treatment is a promising nanotherapeutic *** this work,a multifunctional gold-palladium bimetallic cascade nanozyme was constructed for effective photothermal-enhanced cascade catalyzed synergistic therapy of *** dumbbell-like Au-Pd bimetallic nanomaterial(Au NRs-Pd@HA)was obtained by reducing palladium on gold nanorods with ascorbic acid(AA)and further modified with hyaluronic acid(HA).The introduction of HA brings biocompatibility and targeting *** zebrafish embryos model showed that Au NRs-Pd@HA had good biocompatibility and low *** NRs-Pd@HA can induce catalytic conversion of glucose to generate H_(2)O_(2) efficiently,and subsequently undergo cascade reaction to produce abundant·OH radicals,exhibiting peroxidase-like(POD-like)and glucose oxidase-like(GOD-like)*** generated·OH was a key factor for tumor ***,Au NRs-Pd@HA exhibits good photothermal performance under 808 nm irradiation,in favor of photothermal therapy(PTT).Especially,the POD-like and GOD-like activities were significantly enhanced due to the photothermal *** synergistic PTT and photothermal-enhanced nanozymes with cascade catalytic effect enabled efficient and safe cancer therapy.

关键词： Nanozymes catalyzed therapy Photothermal therapy Cascade catalytic good biocompatibility Cancer Antitumor agents Catalytic therapy

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Fast-response fluorescent probe with favorable water solubility for highly sensitive imaging of endogenous tyrosinase in living cells and zebrafish model

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Chinese Chemical Letters 2021年第5期32卷 1785-1789页

作者： Zheng Li Xiaofeng Xia Yu You Cuifen Lu Guichun Yang Chao Ma Junqi Nie Qi Sun Shuilin Wu Jun Ren Feiyi Wang Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials&Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei UniversityWuhan 430062China Key Laboratory for Green Chemical Process of Ministry of Education and School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China

Tyrosinase(TYR) is an important polyphenolic oxidase enzyme and usually regards as a biomarker of melano ma *** effective tracking TYR activity in vivo will help to study the mechanism of TYR in living organisms and forecasts related *** this study,we present a novel TYR-activatable fluo rescent probe(CHMC-DOPA) for tracking TYR activity in vitro and in ***-DOPA is constructed by incorporating dopamine(DOPA) moiety into a fluorescent chloro-hydroxyl-merocyanine(CHMC)*** exposure to TYR,the dopamine unit in CHMC-DOPA is oxidized to a dopaquinone derivative,and an intramolecular photo-induced electron transfer(PET) process between CHMC fluorophore and o-dopaquinone will take place,the fluorescence of CHMC-DOPA is quenched ***,the evaluation of TYR activity is established in terms of the relationship between fluorescence quenching efficiency and TYR *** our experiments,CHMC-DOPA shows various advantages,such as fast response(8 min),low concentration of TYR activation(0.5 U/mL),good water-solubility,as well as the lowest detection limit(0.003 U/mL) compared with previously reported ***,CHMCDO PA also exhibits excellent cell membrane permeability and low cytotoxicity,which is successfully used to monitor endogenous TYR activity in living cancer cells and zebrafish ***-DOPA performs well,and we anticipate that this newly designed novel platform will provide an alternative for high effective monitoring TYR activity in biosystems.

关键词： Fast-response Fluorescent probe Tyrosinase good biocompatibility Fluorescence imaging

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