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Chemical composition and antibacterial activity of gongronema latifolium

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第5期8卷 352-358页

作者： ELEYINMI Afolabi F. Department of Agricultural Food and Nutritional Sciences University of Alberta Edmonton T6G 2P5 Canada Food Science and Technology Department Federal University of Technology Akure 34001 Ondo State Nigeria

Chemical composition of gongronema latifolium leaves was determined using standard methods. Aqueous and methanol G. latifolium extracts were tested against thirteen pathogenic bacterial isolates. Crude protein, lipid extract, ash, crude fibre and nitrogen flee extractives obtained are： 27.2%, 6.07%, 11.6%, 10.8% and 44.3% dry matter respectively. Potassium, sodium, calcium, phosphorus and cobalt contents are 332, 110, 115, 125 and 116 mg/kg respectively. Dominant essential amino acids are leucine, valine and phenylalanine. Aspartic acid, glutamic acid and glycine are 13.8%, 11,9% and 10.3% respectively of total amino acid. Saturated and unsaturated fatty acids are 50.2% and 39.4% of the oil respectively. Palmitic acid makes up 36% of the total fatty acid. Extracts show no activity against E. faecalis, Y. enterolytica, E. aerogenes, B. cereus and E. agglomerans. Methanol extracts were active against S, enteritidis, S. cholerasius ser typhimurium and P. aeruginosa （minimum inhibitory concentration （MIC） 1 mg; zone of growth inhibition 7, 6.5 and 7 mm respectively）. Aqueous extracts show activity against E. coli （MIC 5 mg） and P. aeruginosa （MIC 1 mg） while methanol extracts are active against P. aeruginosa and L. monocytogenes. G. lafifolium has potential food and antibacterial uses.

关键词： gongronema latifolium Chemical composition Antibacterial activity

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Aqueous Leaves Extract of gongronema latifolium (Benth) Downregulates the Expression of IFN-γ, IL-10 and Cell Surface Markers in Rabbits

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Open Journal of Medical Microbiology 2022年第4期12卷 117-128页

作者： Adekunle Babajide Rowaiye Moses Njoku Angus Nnamdi Oli Nwamaka Henrietta Igbokwe Titilayo Asala Suliat Adebola Salami Ikemefuna Chijioke Uzochukwu Charles Okechukwu Esimone Department of Medical Biotechnology National Biotechnology Development Agency Abuja Nigeria Department of Pharmaceutical Microbiology and Biotechnology Faculty of Pharmaceutical Sciences Nnamdi Azikiwe University Agulu Nigeria Department of Pharmaceutical Microbiology and Biotechnology Faculty of Pharmaceutical Sciences Nnamdi Azikiwe University Agulu Nigeria Department of Pharmaceutical Microbiology and Biotechnology Nigerian Institute of Pharmaceutical Research & Development Abuja Nigeria Department of Pharmaceutical Microbiology and Biotechnology Faculty of Pharmacy College of Medicine Campus University of Lagos Akoka Nigeria Bio-Entrepreneurship and Extension Services Department National Biotechnology Development Agency Abuja Nigeria Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences Nnamdi Azikiwe University Agulu Nigeria

Background: The pathophysiology of the inflammatory process reveals intricate signaling which includes the IL-1β, IL-6, and TNFα pathways that could serve as drug targets. Aim: This study determined the effect of the aqueous extract of gongronema latifolium (AEGL) leaves on the expression of IFNγ, IL-10, CD3, and CD56 in rabbits. Materials and Methods: ELISA tests were performed to determine the effect of the AEGL on the expression of a pro-inflammatory cytokine (IFNγ), an anti-inflammatory cytokine (IL-10), and CD3 and CD56 cell surface markers in rabbits. Twenty cross-bred male rabbits with an average weight range of 1.0 - 1.5 kg were selected. The rabbits were separated into four groups of four rabbits each treated as follows: Grp1 is the untreated control;Grp2 is the treated control;and Grp3, Grp4, and Grp5 were treated with 200, 400, and 600 mg/kg of AEGL respectively for 28 days. Results: The AEGL showed its greatest inhibitory effect in Group 4 on IL-10 (118.5 pg/ml), and IFNγ (332 pg/ml) on days 14 and 21 respectively. AEGL also showed the highest inhibition of CD3 expression on days 14 and 21 (0 pg/ml) in Group 3;and CD56 expression on day 21 (630.5 pg/ml) in Group 4. Conclusion: AEGL showed exhibited strong T cell mediated anti- inflammatory, and immunomodulatory activity in test rabbits within the 28-day period which can be confirmed by cell based assays. Specifically at 400 mg/kg, AEGL exhibited the greatest anti-inflammatory activity which is suggestive of its maximum effective dose.

关键词： Inflammation Cell Surface Markers Antioxidant Activity Cytokine Hepatic Toxicity Medicinal Plant gongronema latifolium

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Ameliorative and antidyslipidemic potentials of aqueous leaf extract ofgongronema latifoliumin CCl_(4) carbon tetrachloride-induced oxidative stress rats

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Journal of Coastal Life Medicine 2016年第11期4卷 868-873页

作者： Asiat Na’Allah Aliu Babajide Sanusi Hamdala AjokeOwoniyi Abdulhakeem Olarewaju Sulyman Jubril Olayinka Akolade Department of Biological Science College of Natural ScienceAl-Hikmah UniversityIlorinP.M.B.1601Kwara StateNigeria Department of Biosciences and Biotechnology(Biochemistry Unit) Kwara State UniversityMaleteP.M.B.1530IlorinNigeria Biotechnology and Genetic Engineering Advanced Laboratory Sheda Science and Technology ComplexShedaAbuja

Objective:To investigate the effect of leaf aqueous extract from gongronema latifolium(***)on CCl_(4)induced-oxidative stress in Wistar *** effect was assessed by measuring liver marker enzymes activity,analyzing the antioxidant parameters,lipid profile estimation and lipid peroxidation by-product following CCl_(4)induced-oxidative ***:Milled *** leaves were subjected to aqueous extraction and the filtrate was evaporated between 40-60°C under reduced pressure and a calculated volume of the leaf extract was administered at a dose of 500 mg/kg body ***-five rats were grouped into seven groups of 5 animals each namely;control and experimental *** experimental groups were treated with 2.0 mL/kg body weight CCl_(4),25 mg/kg body weight/day silymarin(a standard hepatoprotective antioxidant),500 mg/kg body weight aqueous extract of *** leaves were administered to the CCl_(4)treated rats for 21 ***:Administration of the extract and silymarin increase significantly(P<0.05)in liver marker enzyme(aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and gamma-glutamyl transpeptidase)activities in serum,liver and kidney in the treated groups when compared with untreated *** antioxidant parameters(catalase,peroxidase and glutathione S-transferase)were significantly elevated(P<0.05)in animals treated with the extract and silymarin in comparison with untreated ***_(4)induced oxidative stress mediated variations in total cholesterol,triacylglycerides,high-density lipoprotein cholesterol,low density lipoprotein cholesterol and very low-density lipoprotein cholesterol were restored significantly(P<0.05)by the ***:The result obtained from this study indicated the antioxidant and antidyslipidemic potentials of the aqueous extract of *** leaves.

关键词： Ameliorative Antidyslipidemic gongronema latifolium Oxidative stress

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