Ameliorative and antidyslipidemic potentials of aqueous leaf extract ofGongronema latifoliumin CCl_(4) carbon tetrachloride-induced oxidative stress rats
Ameliorative and antidyslipidemic potentials of aqueous leaf extract ofGongronema latifoliumin CCl4 carbon tetrachloride-induced oxidative stress rats作者机构：Department of Biological ScienceCollege of Natural ScienceAl-Hikmah UniversityIlorinP.M.B.1601Kwara StateNigeria Department of Biosciences and Biotechnology(Biochemistry Unit)Kwara State UniversityMaleteP.M.B.1530IlorinNigeria Biotechnology and Genetic Engineering Advanced LaboratorySheda Science and Technology ComplexShedaAbuja
出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)
年 卷 期：2016年第4卷第11期
页 面：868-873页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Ameliorative Antidyslipidemic Gongronema latifolium Oxidative stress
摘 要：Objective:To investigate the effect of leaf aqueous extract from Gongronema latifolium(***)on CCl_(4)induced-oxidative stress in Wistar *** effect was assessed by measuring liver marker enzymes activity,analyzing the antioxidant parameters,lipid profile estimation and lipid peroxidation by-product following CCl_(4)induced-oxidative ***:Milled *** leaves were subjected to aqueous extraction and the filtrate was evaporated between 40-60°C under reduced pressure and a calculated volume of the leaf extract was administered at a dose of 500 mg/kg body ***-five rats were grouped into seven groups of 5 animals each namely;control and experimental *** experimental groups were treated with 2.0 mL/kg body weight CCl_(4),25 mg/kg body weight/day silymarin(a standard hepatoprotective antioxidant),500 mg/kg body weight aqueous extract of *** leaves were administered to the CCl_(4)treated rats for 21 ***:Administration of the extract and silymarin increase significantly(P0.05)in liver marker enzyme(aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and gamma-glutamyl transpeptidase)activities in serum,liver and kidney in the treated groups when compared with untreated *** antioxidant parameters(catalase,peroxidase and glutathione S-transferase)were significantly elevated(P0.05)in animals treated with the extract and silymarin in comparison with untreated ***_(4)induced oxidative stress mediated variations in total cholesterol,triacylglycerides,high-density lipoprotein cholesterol,low density lipoprotein cholesterol and very low-density lipoprotein cholesterol were restored significantly(P0.05)by the ***:The result obtained from this study indicated the antioxidant and antidyslipidemic potentials of the aqueous extract of *** leaves.
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