检索结果-南通市图书馆

Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy

引用

Cancer Biology & Medicine 2019年第4期16卷 756-770页

作者： Bin Liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan Yanlei Liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine Collaborative Innovational Center for System BiologyShanghai Jiao Tong UniversityShanghai 200240China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Oncology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China

Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted ***:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and *** cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and *** of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and *** fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time *** ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by *** distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA *** combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing ***:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake *** as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic *** as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and ***:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing *** fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future.

关键词： gold nanostars natural killer cells photothermal therapy photodynamic therapy immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脂质体内金纳米星的原位合成以及在药物释放和光声造影上的应用（英文）

引用

Science China Materials 2016年第11期59卷 892-900页

作者： Malathi Mathiyazhakan Paul Kumar Upputuri Kathyayini Sivasubramanian Ashish Dhayani Praveen Kumar Vemula 邹培超浦侃裔杨诚 Manojit Pramanik 徐臣杰 School of Chemical&Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore Institute for Stem Cell Biology and Regenerative Medicine(inStem) GKVK-CampusBellary RoadBangaloreIndia Ramalingaswami Re-Entry Fellow Department of BiotechnologyNew Delhi 110003India Division of Energy&Environment Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China NTU-Northwestern Institute for Nanomedicine Nanyang Technological University50 Nanyang AvenueSingapore

本文通过在脂质体内还原金的前体HAuCl_4原位合成了金纳米星.这种设计跟常用的在脂质体内装载金纳米球的方法相比,优点是方便快捷的同时实现了金纳米材料的形成和装载.通过改变实验条件,合成的金纳米星具有可控的尺寸,以及在可见区到近... 详细信息

本文通过在脂质体内还原金的前体HAuCl_4原位合成了金纳米星.这种设计跟常用的在脂质体内装载金纳米球的方法相比,优点是方便快捷的同时实现了金纳米材料的形成和装载.通过改变实验条件,合成的金纳米星具有可控的尺寸,以及在可见区到近红外区之间的可控吸收光谱.作为一个例子,我们在脂质体内合成了最大吸收在803 nm的金纳米星.这种材料具有温度敏感性,在近红外区可以产生比血液好1.5倍的光声造影信号.当我们把抗癌药物阿霉素装载到这种脂质体内时,近红外区的激光照射可以在10秒内触发药物100%的释放.相对应的,不含纳米星的脂质体在同等条件下只能释放10%的药物,也不具备光声造影的信号增强.最后,我们在癌细胞内测试了该脂质体的疗效,初步验证了该体系的应用前景.

关键词： gold nanostars light sensitive liposomes controlled drug release photoacoustic imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hot spots enriched plasmonic nanostructure-induced random lasing of quantum dots thin film

引用

Chinese Physics B 2018年第4期27卷 497-502页

作者：单锋张晓阳吴静远张彤 Joint International Research Laboratory of Information Display and Visualization School of Electronic Science and EngineeringSoutheast University Suzhou Key Laboratory of Metal Nano-Optoelectronic Technology Suzhou Research Institute of Southeast University Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology Ministry of Educationand School of Instrument Science and EngineeringSoutheast University

Here,a plasmon-enhanced random laser was achieved by incorporating gold nanostars（NS） into disordered polymer and Cd Se/Zn S quantum dots（QDs） gain medium films,in which the surface plasmon resonance of gold NS can greatly enhance the scattering cross section and bring a large gain *** random distribution of gold NS in the gain medium film formed a laser-mode *** a single-pulse pumping,the scattering center of gold NS-based random laser exhibits enhanced performance of a lasing threshold of 0.8 m J/cm^2 and a full width as narrow as 6 nm at half *** utilizing the local enhancement characteristic of the electric field at the sharp apexes of the gold NS,the emission intensity of the random laser was *** addition,the gold NS showed higher thermal stability than the silver nanoparticles,withstanding high temperature heating up to 200？*** results of metal nanostructures with enriched hot spots and excellent temperature stability have tremendous potential applications in the fields of biological identification,medical diagnostics,lighting,and display devices.

关键词： plasmon gain medium gold nanostars random laser

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review of metal nanoparticle-based surface-enhanced Raman scattering substrates for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)detection Special Collection:Distinguished Australian Researchers

Aggregate

引用

Aggregate 2023年第5期4卷 1-11页

作者： Norhayati Abu Bakar Nur Nazhifah Yusoff Farah Shahadah Nor Azmi Joseph George Shapter Australian Institute for Bioengineering and Nanotechnology University of QueenslandSt LuciaAustralia Institute of Microengineering and Nanoelectronics Universiti Kebangsaan MalaysiaBangiMalaysia

Monitoring an infectious disease early using highly sensitive and non-invasive techniques is critical for human ***,the development of surfaceenhanced Raman scattering(SERS)for biological detection ideally fits these medical requirements and is rapidly growing as a powerful diagnostic *** can enhance the Raman signal of the target molecule by more than 106 after the adsorption of the molecule on the plasmonic nanostructured *** review provides an overview of the use of gold and silver nanoparticles in SERS substrate designs,followed by the development of these SERS substrates in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)detection.

关键词： gold nanostars SARS-CoV-2 SERS silver nanostars

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：