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How do lateral septum projections to the ventral CA1 influence sociability?

Neural Regeneration Research 2024年第8期19卷 1789-1801页

作者： Dan Wang Di Zhao Wentao Wang Fengai Hu Minghu Cui Jing Liu Fantao Meng Cuilan Liu Changyun Qiu Dunjiang Liu Zhicheng Xu Yameng Wang Yu Zhang Wei Li Chen Li Department of Rehabilitation Medicine Binzhou Medical University HospitalBinzhouShandong ProvinceChina Medical Research Center Binzhou Medical University HospitalBinzhouShandong ProvinceChina Institute for Metabolic&Neuropsychiatric Disorders Binzhou Medical University HospitalBinzhouShandong ProvinceChina Department of Psychology Binzhou Medical University HospitalBinzhouShandong ProvinceChina College of Nursing Binzhou Medical UniversityBinzhouShandong ProvinceChina

Social dysfunction is a risk factor for several neuropsychiatric *** studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social *** r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea *** this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence *** res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these ***,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in *** findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty *** findings provide new insights rega rding the neural circuits that regulate sociability.

关键词： chemogenetics GABA receptor GABAergic neurons glutamatergic neurons lateral septum neural excitability neural projection social novelty social preference ventral CA1

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The Superior Colliculus:Cell Types,Connectivity,and Behavior

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Neuroscience Bulletin 2022年第12期38卷 1519-1540页

作者： Xue Liu Hongren Huang Terrance PSnutch Peng Cao Liping Wang Feng Wang Shenzhen Key Lab of Neuropsychiatric Modulation Guangdong Provincial Key Laboratory of Brain Connectome and BehaviorCAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health University of British ColumbiaVancouver V6T 1Z4Canada National Institute of Biological Sciences Beijing 100049China

The superior colliculus(SC),one of the most well-characterized midbrain sensorimotor structures where visual,auditory,and somatosensory information are integrated to initiate motor commands,is highly conserved across vertebrate ***,cell-type-specific SC neurons integrate afferent signals within local networks to generate defined output related to innate and cognitive *** review focuses on the recent progress in understanding of phenotypic diversity amongst SC neurons and their intrinsic circuits and long-projection *** further describe relevant neural circuits and specific cell types in relation to behavioral outputs and cognitive *** systematic delineation of SC organization,cell types,and neural connections is further put into context across species as these depend upon laminar ***,we focus on SC neural circuitry involving saccadic eye movement,and cognitive and innate ***,the review provides insight into SC functioning and represents a basis for further understanding of the pathology associated with SC dysfunction.

关键词： Superior colliculus glutamatergic neurons GABAergic neurons Neuronal circuits Innate behaviors

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Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function

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Neural Regeneration Research 2023年第11期18卷 2449-2458页

作者： Jinpiao Zhu Chang Chen Zhen Li Xiaodong Liu Jingang He Ziyue Zhao Mengying He Binbin Nie Zili Liu Yingying Chen Kuanpin Su Xiang Li Juxiang Chen Hongbing Xiang Fuqiang Xu Kangguang Lin Zongze Zhang Jie Wang Department of Anesthesiology Brain Research CenterDepartment of NeurosurgeryZhongnan HospitalWuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology and Pain Medicine Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Anesthesia and Intensive Care Peter Hung Pain Research InstituteThe Chinese University of Hong KongHong Kong Special Administration RegionChina Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei ProvinceChina Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina The Brain Cognition and Brain Disease Institute(BCBDI) NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhenGuangdong ProvinceChina Mind-Body Interface Research Center(MBI-Lab) China Medical University HospitalTaichungTaiwanChina An-Nan Hospital China Medical UniversityTainanTaiwanChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei ProvinceChina University of Chinese Academy of Sciences BeijingChina

Sleep benefits the restoration of energy metabolism and thereby suppo rts neuronal plasticity and cognitive ***6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator of energy metabolism because it modulates various transcriptional regulators and metabolic *** aim of this study was to investigate the influence of Sirt6 on cerebral function after chronic sleep deprivation(CSD).We assigned C57BL/6J mice to control or two CSD groups and subjected them to AAV2/9-CMV-EGFP or AAV2/9-CMV-Sirt6-EGFP infection in the prelimbic cortex(PrL).We then assessed cerebral functional connectivity(FC) using resting-state functional MRI,neuron/astrocyte metabolism using a metabolic kinetics analysis;dendritic spine densities using sparse-labeling;and miniature excitato ry postsynaptic currents(mEPSCs) and action potential(AP) firing rates using whole-cell patchclamp *** addition,we evaluated cognition via a comprehensive set of behavioral *** with controls,Sirt6 was significantly decreased(Pglutamatergic ***,Sirt6 activation may have potential as a novel strategy for treating sleep disorder-related diseases.

关键词： chronic sleep deprivation cognitive impairment functional connectivity glutamatergic neurons metabolic kinetics neuronal-astrocytic glucose metabolism prelimbic cortex REM sleep Sirt6 synaptic function

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Optogenetic activation of glutamatergic neu⁃rons in somatosensory cortex promotes remy⁃elination in ischemic vascular dementia

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中国药理学与毒理学杂志 2021年第9期35卷 696-697页

作者： ZHOU Yi-ting AN Da-dao XU Yi-xin ZHOU Ying LI Qing-qing ZHANG Xiang-nan WANG Yi LOU Min CHEN Zhong HU Wei-wei Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital NHC and CAMS Key Laboratory of Medical Neuro-biologySchool of Basic Medical SciencesCol-lege of Pharmaceutical SciencesZhejiang Univer-sityHangzhou 310012China Department of Pharmacy Sir Run Run Shaw HospitalHangzhou 310020China Key Laboratory of Neurophar-macology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310003China

OBJECTIVE Chronic cerebral hy⁃poperfusion can lead to progressive demyelin⁃ation and ischemic vascular dementia,yet there are no effective *** Magnetic resonance imaging was employed in patients with white matter damage,and optogenetics and skin stroking were exerted to activate glutamater⁃gic neurons in the somatosensory cortex in a clas⁃sical mouse model of ischemia vascular *** White matter damage was correlated with disrupted cortical structure from MRI *** a mouse model,activating glutamatergic neu⁃rons in the somatosensory cortex promotes prolif⁃eration of OPCs and remyelination to rescue cog⁃nitive impairment after chronic cerebral hypoper⁃*** therapeutic action was limited to stimulation with moderate intensity at the upper layers of the cortex,but was achieved over a wide time window after ***,enhanced glutamatergic neuron-OPC functional synaptic connections are required for protection from activation of cortical glutamatergic ***,skin stroking activation of the somatosen⁃sory cortex,an easier approach for clinical trans⁃lation,promoted OPC proliferation and remyelin⁃ation as well as cognitive recovery after cerebral *** Activation of gluta⁃matergic neurons in the somatosensory cortex may serve as novel approaches for treating isch⁃emic vascular dementia through precise modula⁃tion of glutamatergic neuron-OPC circuits.

关键词： optogenetics glutamatergic neurons ischemic vascular dementia

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