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Activation without Proteolysis of Anti-σFactor RsiV of the Extracytoplasmic Function σFactor σVin a glucolipid-Deficient Mutant of Bacillus subtilis

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Advances in Microbiology 2017年第4期7卷 315-327页

作者： Takahiro Seki Kouji Matsumoto Satoshi Matsuoka Hiroshi Hara Department of Biochemistry and Molecular Biology Graduate School of Science and EngineeringSaitama UniversitySaitamaJapan

Extracytoplasmic function (ECF) σ factors are a crucial link in the process of bacterial response to environmental stresses, in which bacteria transmit information across the cytoplasmic membrane. Among the seven ECF σ factors of Bacillus subtilis σV, which is sequestered by transmembrane anti-σ factor RsiV under normal growth conditions, responds to lysozyme. When B. subtilis cells are challenged by lysozyme, the lysozyme-bound RsiV undergoes two successive proteolysis steps, by a signal peptidase and RasP protease, and releases σV. An unchallenged B. subtilis ugtP mutant lacking glucolipids exhibited higher σV activity than wild type. However, the activation occurred in the absence of RasP, and no proteolysis of RsiV was observed. It is likely that a conformational change, not proteolysis, of RsiV leads to this activation of σV in the absence of glucolipids. Replacement of the C-terminal region of RsiV with that of RsiW, the cognate σ factor of which, σW, is not activated in the ugtP mutant, indicated that the C-terminal extracytoplasmic region of RsiV was necessary for the response to glucolipid deficiency.

关键词： Anti-σ Factor Bacillus subtilis ECF σ Factor glucolipid RsiV σV UgtP

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Characteristics of glucolipid metabolism as well as atherosclerosis in patients with obstructive sleep apnea-hypopnea syndrome combined with cerebral infarction

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Journal of Hainan Medical University 2018年第8期24卷 57-60页

作者： Yan-Li Cai Jian-Qiang Hao Hai-Bin Wang Department of Neurology Ziyang HospitalWest China HospitalSichuan University.First People's Hospital of Ziyang CityZiyangSichuanProvince641300China Department of Neurosurgery Ziyang Hospital of West China HospitalSichuan University.First People's Hospital of Ziyang CityZiyangSichuanProvince641300China

Objective:To evaluate the characteristics of glucolipid metabolism as well as atherosclerosis in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) combined with cerebral ***:Patients who were treated in the hospital due to acute cerebral infarction between March 2015 and February 2018 were selected, and according to the combination of OSAHS, the 300 patients with cerebral infarction were divided into the cerebral infarction group A who were combined with OSAHS and the cerebral infarction group B who were not combined with OSAHS;the 100 cases of healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The contents of glucolipid metabolism indexes, cytokines and plaque hydrolysis molecules in serum were ***: Serum F-Ins, TC, LDL-C, VE-cadherin, YKL-40, FKN, M-CSF, MCP-1, MMP9, Caspase-3, ICTP and VCAM-1 levels of cerebral infarction group A and cerebral infarction group B were significantly higher than those of control group whereas HDL-C levels were significantly lower than that of control group;serum F-Ins, TC, LDL-C, VE-cadherin, YKL-40, FKN, M-CSF, MCP-1, MMP9, Caspase-3, ICTP and VCAM-1 levels of cerebral infarction group A were significantly higher than those of cerebral infarction group B whereas HDL-C level was significantly lower than that of cerebral infarction group ***: There are more significant glucolipid metabolism disorder and worse plaque stability in patients with OSAHS combined with cerebral infarction.

关键词： Cerebral infarction Obstructive sleep apnea-hypopnea syndrome glucolipid metabolism Atherosclerosis

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Effects of sleeve gastrectomy with jejuno-jejunal or jejuno-ileal loop on glycolipid metabolism in diabetic rats

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World Journal of Gastroenterology 2016年第32期22卷 7332-7341页

作者： Ming-Wei Zhong Shao-Zhuang Liu Guang-Yong Zhang Xiang Zhang San-Yuan Hu Department of General Surgery Qilu Hospital of Shandong University

AIM To explore the effect of sleeve gastrectomy(SG) with jejuno-jejunal or jejuno-ileal loop on glycolipid metabolism in diabetic *** Diabetic rats, which were induced by high-fat diet(HFD), nicotinamide and low-dose streptozotocin, underwent sham operations, SG, SG with jejuno-ileal loop(SG-JI) and SG with jejuno-jejunal loop(SG-JJ) followed by postoperative HFD. Then, at the time points of baseline and 2, 12 and 24 wk postoperatively, we determined and compared several variables, including the area under the curve for the results of oral glucose tolerance test(AUCOGTT), serum levels of triglyceride, cholesterol and ghrelin in fasting state, homeostasis model assessment of insulin resistance(HOMA-IR), body weight, calorie intake, glucagon-like peptide(GLP)-1 and insulin secretions after glucose gavage at dose of 1 g/*** At 2 wk postoperatively, rats that underwent SG, SGJJ and SG-JI, compared with sham-operated(SHAM)rats, demonstrated lower body weight, calorie intake and ghrelin(P glucolipid metabolism was still evident(P < 0.05 vs SG). SG-JI had a better performance in lipid metabolism and GLP-1 secretion of rats than did *** SG combined with intestinal loop ind

关键词： Sleeve gastrectomy Jejuno-jejunal loop Jejuno-ileal loop Diabetes glucolipid metabolism

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