Characteristics of glucolipid metabolism as well as atherosclerosis in patients with obstructive sleep apnea-hypopnea syndrome combined with cerebral infarction

作     者：Yan-Li Cai Jian-Qiang Hao Hai-Bin Wang 

作者机构：Department of NeurologyZiyang HospitalWest China HospitalSichuan University.First People's Hospital of Ziyang CityZiyangSichuanProvince641300China Department of NeurosurgeryZiyang Hospital of West China HospitalSichuan University.First People's Hospital of Ziyang CityZiyangSichuanProvince641300China 

出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)

年 卷 期：2018年第24卷第8期

页      面：57-60页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Medical Scientific Research Youth Innovation Project of Sichuan Province No: Q16004 

主　　题：Cerebral infarction Obstructive sleep apnea-hypopnea syndrome Glucolipid metabolism Atherosclerosis 

摘      要：Objective:To evaluate the characteristics of glucolipid metabolism as well as atherosclerosis in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) combined with cerebral ***:Patients who were treated in the hospital due to acute cerebral infarction between March 2015 and February 2018 were selected, and according to the combination of OSAHS, the 300 patients with cerebral infarction were divided into the cerebral infarction group A who were combined with OSAHS and the cerebral infarction group B who were not combined with OSAHS;the 100 cases of healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The contents of glucolipid metabolism indexes, cytokines and plaque hydrolysis molecules in serum were ***: Serum F-Ins, TC, LDL-C, VE-cadherin, YKL-40, FKN, M-CSF, MCP-1, MMP9, Caspase-3, ICTP and VCAM-1 levels of cerebral infarction group A and cerebral infarction group B were significantly higher than those of control group whereas HDL-C levels were significantly lower than that of control group;serum F-Ins, TC, LDL-C, VE-cadherin, YKL-40, FKN, M-CSF, MCP-1, MMP9, Caspase-3, ICTP and VCAM-1 levels of cerebral infarction group A were significantly higher than those of cerebral infarction group B whereas HDL-C level was significantly lower than that of cerebral infarction group ***: There are more significant glucolipid metabolism disorder and worse plaque stability in patients with OSAHS combined with cerebral infarction.