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ginseng total saponins Enhance Neurogenesis after Focal Cerebral Ischemia

Ginseng Total Saponins Enhance Neurogenesis after Focal Cere...

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中华中医药学会第三次血栓病学术会议暨河南省中西医结合学会心血管病专业委员会、山东省中西医结合学会活血化瘀专业委员会年会、冠心病中医、中西医结合诊疗新进展学习班、全国心血管疾病中西医结合诊治新进展学习班

作者： Guo-qing Zheng,Wei Cheng,Yan Wang,Xiu-min Wang,Shu-zhi Zhao,Yun Zhou,Shi-jue Liu,Xiao-tong Wang Center of Neurology and Rehabilitation,The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,PR China

Background:Stroke is associated with high mortality and major disability burdens worldwide,but there are few effective and widely available *** is one of the most commonly used healing herbs for stroke and chronic debilitating conditions in *** are the main active principles of ginsengs efficacy,but the mechanisms have not been fully ***:To test the hypothesis that the administration of ginseng total saponins(GTS) after focal cerebral ischemia may induce endogenous neural stem cells activation and adult central nervous system regeneration,and thereby improve neurological deficits. Methods:The rats were randomly divided into sham-operation(Sham) group,normal sodium(NS) group and GTS *** group and GTS group were further divided into four sub-groups according the time point 1d,3 d,7 d and 14 d with 8 rats per sub-group after the permanent middle cerebral artery occlusion(MCAO) insult. Rats in GTS groups received intraperitoneal injections of GTS dissolved at a dose of 25 mg·kg·*** in NS group were only received intraperitoneal injections of same amount *** injections of GTS or NS twice daily were start to perform 3 days before model establishment until the animals were *** sham animals received neither GTS nor *** neurological status of the awake rats was assessed blindly after model establishment at 1d,3d,7 d and 14 d, *** immunostaining and double staining were performed by following the 3-steps ***:A,GTS-treated rats have better neurological scores compared with those in normal saline(NS) group at 14 d time point(p<0.05);B, at 3d,7d and 14d time point,BrdU-positive cell numbers in GTS group were significantly higher than those in NS group in the ipsilateral subventricular zone(SVZ) after middle cerebral artery occlusion(MCAO)(p<0.05,or p<0.01);BrdU/NeuN cell numbers in GTS group also were significantly higher than those in NS group in the ipsilateral infarct area a

关键词： Focal cerebral ischemia Neurogenesis Neurological function ginseng total saponins

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