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Comparison of clinicopathological characteristics and survival outcomes between gallbladder mucinous adenocarcinoma and gallbladder adenocarcinoma:A propensity score-matched study

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1436-1450页

作者： Wen-Wei Yang Yu-Ting Fang Ya-Ru Niu Yong-Kun Sun Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer HospitalLangfang 065001Hebei ProvinceChina

BACKGROUND gallbladder mucinous adenocarcinoma(GBMAC)is a rare subtype of gallbladder adenocarcinoma(GBAC),with limited knowledge of its survival outcomes from small case series and single-center retrospective *** To compare the clinicopathological characteristics of GBMAC with typical GBAC and its prognostic factors to gain insights into this *** This study was conducted using data from the Surveillance,Epidemiology,and End Results database,including cases of GBMAC and typical GBAC diagnosed from 2010 to *** Pearson chi-square test or Fisher exact test was used to examine the differences in clinicopathological features between these two *** addition,propensity score matching(PSM)analysis was performed to balance the selection *** and multivariate Cox hazards regression analyses were performed to determine independent prognostic factors for cancer-specic survival(CSS)and overall survival(OS).The Kaplan–Meier curves and log-rank tests were used to assess the OS and CSS of GBMAC and typical GBAC *** The clinicopathological and demographic characteristics of GBMAC were different from typical *** included a larger proportion of patients with unmarried status,advanced American Joint Committee on Cancer(AJCC)stage,higher T stage,higher N1 stage rate and lower N0 and N2 stage rates(P<0.05).Multivariate analyses demonstrated that surgery[OS:Hazard ratio(HR)=2.27,P=0.0037;CSS:HR=2.05,P=0.0151],chemotherapy(OS:HR=6.41,P<0.001;CSS:HR=5.24,P<0.001)and advanced AJCC stage(OS:Stage IV:HR=28.99,P=0.0046;CSS:Stage III:HR=12.31,P=0.015;stage IV:HR=32.69,P=0.0015)were independent prognostic indicators for OS and CSS of GBMAC ***,after PSM analysis,there was no significant difference between GBMAC and matched typical GBAC patients regarding OS(P=0.82)and CSS(P=0.69).CONCLUSION The biological behaviors of GBMAC are aggressive and significantly different from that of typical ***,they show similar

关键词： gallbladder mucinous adenocarcinoma gallbladder adenocarcinoma Surveillance,Epidemiology,and End Results Prognosis Risk factors

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Hodgkin lymphoma masquerading as perforated gallbladder adenocarcinoma:A case report

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1279-1284页

作者： Michelle Manesh Reynold Henry Shea Gallagher Michael Greas Mohd Raashid Sheikh Shannon Zielsdorf Department of Surgery University of Southern CaliforniaLos AngelesCA 90033United States Department of Pathology University of Southern CaliforniaLos AngelesCA 90033United States

BACKGROUND There are several case reports of acute cholecystitis as the initial presentation of lymphoma of the gallbladder;all reports describe non-Hodgkin lymphoma or its subtypes on histopathology of the gallbladder tissue ***,there is no description in the literature of Hodgkin lymphoma causing hilar lymphadenopathy,inevitably presenting as ruptured cholecystitis with imaging mimicking gallbladder *** SUMMARY A 48-year-old man with a past medical history of diabetes mellitus presented with progressive abdominal pain,jaundice,night sweats,weakness,and unintended weight loss for one ***-up revealed a mass in the region of the porta hepatis causing obstructions of the cystic and common hepatic ducts,gallbladder rupture,as well as retroperitoneal *** clinical picture and imaging findings were suspicious for locally advanced gallbladder adenocarcinoma causing ruptured cholecystitis and cholangitis,with metastases to retroperitoneal lymph *** invasive techniques,including endoscopic duct brushings and percutaneous lymph node biopsy,were inadequate for tissue ***,this case required exploratory laparo-tomy,open cholecystectomy,and periaortic lymph node dissection for histopathological assessment and definitive *** lymphoma was present in the lymph nodes while the gallbladder specimen had no evidence of *** This clinical scenario highlights the importance of histopathological assessment in diagnosing gallbladder malignancy in a patient with gallbladder perforation and a grossly positive positron emission tomography/computed tomography *** both gallbladder adenocarcinoma and Hodgkin lymphoma,medical and surgical therapies must be tailored to the specific disease entity in order to achieve optimal long-term survival rates.

关键词： Hodgkin lymphoma gallbladder perforation Acute cholecystitis gallbladder adenocarcinoma Case report

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