Hodgkin lymphoma masquerading as perforated gallbladder adenocarcinoma:A case report

作     者：Michelle Manesh Reynold Henry Shea Gallagher Michael Greas Mohd Raashid Sheikh Shannon Zielsdorf 

作者机构：Department of SurgeryUniversity of Southern CaliforniaLos AngelesCA 90033United States Department of PathologyUniversity of Southern CaliforniaLos AngelesCA 90033United States 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第10期

页      面：1279-1284页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hodgkin lymphoma Gallbladder perforation Acute cholecystitis Gallbladder adenocarcinoma Case report 

摘      要：BACKGROUND There are several case reports of acute cholecystitis as the initial presentation of lymphoma of the gallbladder;all reports describe non-Hodgkin lymphoma or its subtypes on histopathology of the gallbladder tissue ***,there is no description in the literature of Hodgkin lymphoma causing hilar lymphadenopathy,inevitably presenting as ruptured cholecystitis with imaging mimicking gallbladder *** SUMMARY A 48-year-old man with a past medical history of diabetes mellitus presented with progressive abdominal pain,jaundice,night sweats,weakness,and unintended weight loss for one ***-up revealed a mass in the region of the porta hepatis causing obstructions of the cystic and common hepatic ducts,gallbladder rupture,as well as retroperitoneal *** clinical picture and imaging findings were suspicious for locally advanced gallbladder adenocarcinoma causing ruptured cholecystitis and cholangitis,with metastases to retroperitoneal lymph *** invasive techniques,including endoscopic duct brushings and percutaneous lymph node biopsy,were inadequate for tissue ***,this case required exploratory laparo-tomy,open cholecystectomy,and periaortic lymph node dissection for histopathological assessment and definitive *** lymphoma was present in the lymph nodes while the gallbladder specimen had no evidence of *** This clinical scenario highlights the importance of histopathological assessment in diagnosing gallbladder malignancy in a patient with gallbladder perforation and a grossly positive positron emission tomography/computed tomography *** both gallbladder adenocarcinoma and Hodgkin lymphoma,medical and surgical therapies must be tailored to the specific disease entity in order to achieve optimal long-term survival rates.