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Pharmacology & Pharmacy 2011年第4期2卷 271-281页

作者： Vijay K. Agrawal Basheerulla Shaik Padmakar V. Khadikar Shalini Singh 不详

Quantitative Structure-Activity Relationship (2D-QSAR) models for binding affinity constants (log Ki) of 78 flavanoid ligands towards the benzodiazepine site of gaba (A) receptor complex were estimated using the PRECLAV (Property-Evaluation by Class Variables) program. The best MLR equation with nine PRECLAV descriptors has R2 = 0.843 and R2C = 0.782. Attempt is also made for obtaining 2D-QSAR model using NCSS software. The comparison of the results indicated that the PRECLAV method is very efficient in detecting structure-activity correlation with good predictive power.

关键词： PRECLAV NCSS Regression Analysis Cross-Validation gaba Flavanoids

gaba抑制hCG诱发大鼠卵巢黄体细胞孕酮生成

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基础医学与临床 2004年第1期24卷 40-43页

作者：张辉张玮倪江田淑君边淑玲张丽敏哈尔滨医科大学生理教研室哈尔滨150086

观察了中枢抑制性神经递质γ 氨基丁酸 (gaba)对人绒毛膜促性腺激素 (hCG)诱发大鼠卵巢黄体细胞孕酮的生成 ,及对羟自由基 (·OH)产生的影响。结果显示 :gaba抑制基础及hCG诱发黄体细胞孕酮的生成 ,同时发现黄体细胞羟自由基的生成增多... 详细信息

观察了中枢抑制性神经递质γ 氨基丁酸 (gaba)对人绒毛膜促性腺激素 (hCG)诱发大鼠卵巢黄体细胞孕酮的生成 ,及对羟自由基 (·OH)产生的影响。结果显示 :gaba抑制基础及hCG诱发黄体细胞孕酮的生成 ,同时发现黄体细胞羟自由基的生成增多。表明 :gaba抑制孕酮的生成可能与自由基有关 ,并可能通过cAMP PKA系统发挥作用。

关键词： gaba hCG 大鼠卵巢黄体细胞孕酮 γ-氨基丁酸中枢抑制性神经递质人绒毛膜促性腺激素

Effect of Microiontophoretically Applied gaba on Medullary Respiratory Neurons in the Region of Nucleus Tractus Solitarius of Rabbit

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Journal of Medical Colleges of PLA 1986年第1期 87-92页

作者：熊焕贵陈肇熙 Department of Physiology First Military Medical College Guangzhou

Experiments were performed on 19 vagotomized,curareparalyzed andartificially ventilated rabbits.3-5 barrel glass micropipettes were used torecord the extracellular discharges and to apply the ionized substances *** respiratory units located in the region of Nucleus Treactus Soli-tarius were tested for their responsiveness to iontophoretically *** tended to inhibit not only inspiratory units but also expi-ratory *** 60 units tested,49 were inhibited and the inhibitoryeffect of gaba had much to do with its quantity *** nervedischarges were unchanged while the discharges of respiratory units weredepressed by *** inhibitory effect of gaba could be blocked *** results indicate that gaba may be one of the importantinhibitory neurotransmitters in the medullary“respiratory center”.

关键词： microiontophoresis gaba NTS respiratory neurons inhibition

gaba受体Poly(A)~+mRNA在卵母细胞体内的翻译及其移植受体的生化药理特性

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中国药理学与毒理学杂志 1986年第1期1卷 26-34页

作者：王家蓓孙曼霁军事医学科学院药理毒理研究所北京 100800 军事医学科学院药理毒理研究所

采用SDS/氯仿/苯酚法和oligo(dT)纤维素亲和层析法从胚鸡脑中提取的poly(A)~+mRNA注射到非州爪蟾卵母细胞体内可以成功地被翻译为具有结合功能的gaba受体,并首次用生化方法,包括[~sH]gaba配体结合试验及药物竞争性结合试验证明了卵母细... 详细信息

采用SDS/氯仿/苯酚法和oligo(dT)纤维素亲和层析法从胚鸡脑中提取的poly(A)~+mRNA注射到非州爪蟾卵母细胞体内可以成功地被翻译为具有结合功能的gaba受体,并首次用生化方法,包括[~sH]gaba配体结合试验及药物竞争性结合试验证明了卵母细胞膜上移植gaba受体的存在。蛋白质翻译抑制剂三尖杉酯碱可以完全阻断gaba受体的翻译过程。DNA转录抑制剂放线菌素D对这一过程无影响。移植gaba受体具有受体与配体结合的饱和特性,移植gaba受体与[~sH]gaba的结合可以被调变蛋白、蝇蕈醇、双可可碱及异丙基双环磷酸酯所抑制。移植gaba受体与天然鸡脑gaba受体的生化药理学性质基本一致。

关键词： Poly(A)~+mRNA 非洲爪蟾卵母细胞蝇蕈醇移植gaba受体异丙基双环磷酸酯 gaba 双可可碱

gaba能抑制调制大棕蝠下丘听神经元时间编码模式

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生物物理学报 2002年第4期18卷 399-403页

作者：栾瑞红 P.H.S.JEN 孙心德华东师范大学生命科学学院脑科学研究中心上海200062

大棕蝠(Eptesicusfuscus)下丘神经元对重复率为10 pps(pulse per second)、30 pps的串声刺激均产生跟随反应,但对90 pps串声刺激的跟随反应则不尽相同。微电泳bicuculline阻断gaba能抑制作用后,所记录的58个神经元中,有13个(22%)放电率... 详细信息

大棕蝠(Eptesicusfuscus)下丘神经元对重复率为10 pps(pulse per second)、30 pps的串声刺激均产生跟随反应,但对90 pps串声刺激的跟随反应则不尽相同。微电泳bicuculline阻断gaba能抑制作用后,所记录的58个神经元中,有13个(22%)放电率及串声刺激反应模式无变化;45个(78%)神经元放电率有不同程度的增加,对10 pps、30 pps串声刺激仍能产生跟随反应,但对90 pps串声刺激的跟随反应模式有多种变化。其中: 17个(29%)神经元为放电率增加的跟随反应;9个(15%)神经元放电率增加,对前100 ms的串刺激产生反应且放电密集,而对随后200 ms的串刺激只产生少量的放电;15个(26%)神经元放电率增加,在前几十毫秒范围内有较多的放电反应,后续的反应很弱;4个(7%)神经元只对第一个声刺激产生反应,且放电率增加,随后放电急剧减少。结果提示中脑下丘神经元对听觉信息的时间编码可能具有更复杂的机理。

关键词： gaba gabaA受体串刺激重复率回声定位

Effects of Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture on the Differential Expression of gaba<sub>A</sub>Receptor <i>α</i>Subunits in Hypothalamus of Precocious Puberty Female Rats

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Chinese Medicine 2013年第3期4卷 87-96页

作者： Jing Li Yanyan Sun Shiran Wang Jian Yu Zhanzhuang Tian Department of Integrative Medicine and Neurobiology Institute of Acupuncture Research Institutes of Brain Science State Key Laboratory of Medical Neurobiology Shanghai Medical College of Fudan University Shanghai China Department of Integrative Medicine Children’s Hospital of Fudan University Shanghai China

gabaergic input to Gonadotropin-releasing hormone (GnRH) neurons is necessary to initiate the onset of puberty and its action mainly depends on gabaA receptor of which the subunit composition, properties and consequently function varies during this period. Nourishing “Yin”-Removing “Fire” Chinese herb mixture, a Chinese herb-based formulation, has been proved that it may retard the initiation of pubertal development in female precocious puberty rats. Our objective is to investigate the effects of Nourishing “Yin”-Removing “Fire” Chinese herb mixture on the expression of gabaA receptor α subunits in hypothalamus. Female Sprague-Dawley rats were divided into normal (N), precocious puberty model (M) induced by danazol, model exposed to saline (MS) and model exposed to Chinese herb mixture (CHM) groups. All rats were administered by the Chinese herb mixture from P15 on. Coefficients of reproductive organs and serum gonadotropins and estradiol levels in M were significantly enhanced while they were significantly decreased in CHM. The hypothalamic GnRH mRNA was also significantly increased in M and in CHM, as well as ERα mRNA. At the mean time, the hypothalamic gabaA receptor α1 and α3 subunits mRNA were more significantly decreased in M than those of N, while they were more significantly enhanced in CHM than those in M (p 0.01), the protein expression of which in hypothalamus had the same trend as the mRNA expression. The evidence suggests that Nourishing “Yin”-Removing “Fire” Chinese herb mixture could significantly retard the sexual development of the precocious rats, and up-regulate the expressions of hypothalamic gabaA receptor α1 and α3 subunits. Our result indicated that gabaA receptor α1 and α3 subunits might involve in the effective treatment of herb mixture on idiopathic precocious puberty.

关键词： gaba gabaA Receptor α Subunit Precocious Puberty Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture Rat

Modulation of cell surface gaba B receptors by desensitization,trafficking and regulated degradation

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World Journal of Biological Chemistry 2012年第4期3卷 61-72页

作者： Dietmar Benke Khaled Zemoura Patrick J Maier Institute of Pharmacology and Toxicology University of ZürichWinterthurerstrasse 1908057 ZurichSwitzerland

Inhibitory neurotransmission ensures normal brain function by counteracting and integrating excitatory activity.-Aminobutyric acid (gaba) is the main inhibitory neurotransmitter in the mammalian central nervous system,and mediates its effects via two classes of receptors:the gaba A and gaba B *** A receptors are heteropentameric gaba-gated chloride channels and responsible for fast inhibitory *** B receptors are heterodimeric G protein coupled receptors (GPCR) that mediate slow and prolonged inhibitory *** extent of inhibitory neurotransmission is determined by a variety of factors,such as the degree of transmitter release and changes in receptor activity by posttranslational modifications (e.g.,phosphorylation),as well as by the number of receptors present in the plasma membrane available for signal *** level of gaba B receptors at the cell surface critically depends on the residence time at the cell surface and finally the rates of endocytosis and *** this review we focus primarily on recent advances in the understanding of trafficking mechanisms that determine the expression level of gaba B receptors in the plasma membrane,and thereby signaling strength.

关键词： gaba B receptors Neuron Trafficking Endocytosis Recycling Degradation

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gaba对热应激仔鸡的影响

Zoological Research 2002年第4期23卷 341-344页

作者：陈忠王婷黄丽明方代南海南师范学院生物系海南海口571158

将一周龄的“882”肉仔鸡 ,随机分为 2组。让对照组仔鸡饮用蒸馏水 ,让试验组饮用 0 0 5 %的氨酪酸 (gaba)蒸馏水。 2组每天置于 32℃的箱中热处理 1 5h ,试验 4周。结果表明gaba对热应激肉仔鸡有一定的影响 :试验组仔鸡的呼吸频率极... 详细信息

将一周龄的“882”肉仔鸡 ,随机分为 2组。让对照组仔鸡饮用蒸馏水 ,让试验组饮用 0 0 5 %的氨酪酸 (gaba)蒸馏水。 2组每天置于 32℃的箱中热处理 1 5h ,试验 4周。结果表明gaba对热应激肉仔鸡有一定的影响 :试验组仔鸡的呼吸频率极显著低于对照组 (P <0 0 1) ;红细胞数显著高于对照组 (P <0 0 5 ) ;料重比极显著低于对照组 (P <0 0 1) ,仔鸡增重是对照组鸡的 117 86 % (P <0 0 5 )。

关键词： gaba 热应激仔鸡影响生产性能添加效应

Prospects of Using Platelets as Peripheral Marker to Study the Role of gaba in Autism

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World Journal of Neuroscience 2014年第5期4卷 437-442页

作者： Saima Khan Kaneez Fatima-Shad Hashmet Parveen Ghouse Department of Biomedical Sciences PAP RSB Institute of Health Sciences University Brunei Darussalam Brunei Darussalam School of Medical and Molecular Biosciences Faculty of Science University of Technology Sydney Australia

Literature indicated that platelets could be used as a model for neuronal receptors such as γ-amino butyric acid (gaba) and serotonin. Research work exhibited the presence of low levels of gaba and high levels of serotonin concentration in the platelets of autistic children as compare to their healthy counter parts. There are also other evidences pointing out to the significant role of gaba in autism such as association of g-band frequency with the cortical concentration of gaba and gabapentin (gaba analogue) specifically inhibits the cytosolic branched chain amino transferase (BCATc);an enzyme responsible to modulate glutamate availability for the synthesis of gaba.

关键词： Autism gaba Serotonin Platelets Neurotransmitters

Gamma-aminobutyric acid and gaba_A receptors are involved in directional selectivity of pretectal neurons in pigeons

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Science China(Life Sciences) 2000年第3期43卷 280-286页

作者：肖泉付煜西胡婧高洪峰王书荣 Laboratory for Visual Information Processing Institute of Biophysics Chinese Academy of Sciences Beijing 100101China

The present study describes the effects of gamma-aminobutyric acid (gaba) and its antagonists, bicuculline and 2-hydroxysaclofen, on visual responses of neurons in the pigeon nucleus lentiformis mesencephali (nLM). The results indicate that gaba significantly reduces both spontaneous activity and visual responsiveness, and gabaA antagonist bicuculline but not gabaB antagonist 2-hydroxysaclofen enhances visual responses of nLM cells examined. Furthermore, inhibition produced by motion in the null-direction of pretectal neurons is diminished by bicuculline but not by 2-hydroxysaclofen. It is therefore concluded that the null-direction inhibition of directional cells in the pigeon nLM is predominantly mediated by gaba and gabaA receptors. This inhibition may at least in part underlie directional asymmetry of optokinetic responses.

关键词： directional selectivity gaba nucleus lentiformis mesencephali optokinetic nystagmus pigeon.