Modulation of cell surface GABA B receptors by desensitization,trafficking and regulated degradation

作     者：Dietmar Benke Khaled Zemoura Patrick J Maier 

作者机构：Institute of Pharmacology and ToxicologyUniversity of ZürichWinterthurerstrasse 1908057 ZurichSwitzerland 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2012年第3卷第4期

页      面：61-72页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Supported by The Swiss Science Foundation Grant 31003A_121963 

主　　题：GABA B receptors Neuron Trafficking Endocytosis Recycling Degradation 

摘      要：Inhibitory neurotransmission ensures normal brain function by counteracting and integrating excitatory activity.-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system,and mediates its effects via two classes of receptors:the GABA A and GABA B *** A receptors are heteropentameric GABA-gated chloride channels and responsible for fast inhibitory *** B receptors are heterodimeric G protein coupled receptors (GPCR) that mediate slow and prolonged inhibitory *** extent of inhibitory neurotransmission is determined by a variety of factors,such as the degree of transmitter release and changes in receptor activity by posttranslational modifications (e.g.,phosphorylation),as well as by the number of receptors present in the plasma membrane available for signal *** level of GABA B receptors at the cell surface critically depends on the residence time at the cell surface and finally the rates of endocytosis and *** this review we focus primarily on recent advances in the understanding of trafficking mechanisms that determine the expression level of GABA B receptors in the plasma membrane,and thereby signaling strength.