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3D printing for ultra-precision machining:current status,opportunities,and future perspectives

Frontiers of Mechanical Engineering 2024年第4期19卷 1-28页

作者： Tao HE Wai Sze YIP Edward Hengzhou YAN Jiuxing TANG Muhammad REHAN Long TENG Chi Ho WONG Linhe SUN Baolong ZHANG Feng GUO Shaohe ZHANG Suet TO State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Physics The Hong Kong University of Science and TechnologyHong KongChina School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

Additive manufacturing,particularly 3D printing,has revolutionized the manufacturing industry by allowing the production of complex and intricate parts at a lower cost and with greater ***,3D-printed parts frequently require post-processing or integration with other machining technologies to achieve the desired surface finish,accuracy,and mechanical ***-precision machining(UPM)is a potential machining technology that addresses these challenges by enabling high surface quality,accuracy,and repeatability in 3D-printed *** study provides an overview of the current state of UPM for 3D printing,including the current UPM and 3D printing stages,and the application of UPM to 3D *** the presentation of current stage perspectives,this study presents a detailed discussion of the benefits of combining UPM with 3D printing and the opportunities for leveraging UPM on 3D printing or supporting each *** particular,future opportunities focus on cutting tools manufactured via 3D printing for UPM,UPM of 3D-printed components for real-world applications,and post-machining of 3D-printed ***,future prospects for integrating the two advanced manufacturing technologies into potential industries are *** study concludes that UPM is a promising technology for 3D-printed components,exhibiting the potential to improve the functionality and performance of 3D-printed products in various *** also discusses how UPM and 3D printing can complement each other.

关键词： ultra-precision machining 3D printing additive manufacturing future perspectives start-of-the-art-review

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Building on the backbone of CD47-based therapy in cancer:Combination strategies,mechanisms,and future perspectives

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1467-1487页

作者： Zi-Han Ye Wei-Bang Yu Mu-Yang Huang Jun Chen Jin-Jian Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research University of MacaoMacao 999078China

Described as a“don't eat me”signal,CD47 becomes a vital immune checkpoint in *** interaction with signal regulatory protein alpha(SIRPa)prevents macrophage *** recent years,a growing body of evidences have unveiled that CD47-based combination therapy exhibits a superior anti-cancer *** clinical trials about CD47 have adopted the regimen of collaborating with other therapies or developing CD47-directed bispecific antibodies,indicating the combination strategy as a general trend of the *** this review,clinical and preclinical cases about the current combination strategies targeting CD47 are collected,their underlying mechanisms of action are discussed,and ideas from future perspectives are shared.

关键词： CD47 Combination strategies Bispecific antibodies Clinical data Preclinical data Cancer Mechanisms future perspectives

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Therapeutic strategies for gastroenteropancreatic neuroendocrine neoplasms: State-of-the-art and future perspectives

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World Journal of Gastrointestinal Surgery 2022年第2期14卷 78-106页

作者： Elettra Merola Andrea Michielan Umberto Rozzanigo Marco Erini Sandro Sferrazza Stefano Marcucci Chiara Sartori Chiara Trentin Giovanni de Pretis Franca Chierichetti Department of Gastroenterology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Radiology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Nuclear Medicine Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Surgery Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Pathology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Medical Oncology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy

Although gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)have always been considered rare tumors,their incidence has risen over the past few *** represent a highly heterogeneous group of neoplasms with several prognostic factors,including disease stage,proliferative index(Ki67),and tumor *** of these neoplasms express somatostatin receptors on the cell surface,a feature that has important implications in terms of prognosis,diagnosis,and *** International Guidelines propose algorithms aimed at guiding therapeutic strategies,GEP-NEN patients are still very different from one another,and the need for personalized treatment continues to *** surgery is always the best option when feasible;however,up to 80%of cases are metastatic upon *** medical treatments,as GEP-NENs are characterized by relatively long overall survival,multiple therapy lines are adopted during the lifetime of these patients,but the optimum sequence to be followed has never been clearly ***,although new molecular markers aimed at predicting the response to therapy,as well as prognostic scores,are currently being studied,their application is still far from being part of daily clinical *** they represent a complex disease,with therapeutic protocols that are not completely standardized,GEP-NENs require a multidisciplinary *** review will provide an overview of the available therapeutic options for GEP-NENs and attempts to clarify the possible approaches for the management of these patients and to discuss future perspectives in this field.

关键词： Gastroenteropancreatic neuroendocrine neoplasms Therapeutic strategies Radical surgery Medical treatments Overview future perspectives

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang Jun-Bang Feng Chuan-Ming Li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss future perspectives Limitations Neural conduction

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Magnesium-based biomaterials as emerging agents for bone repair and regeneration:from mechanism to application

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Journal of Magnesium and Alloys 2021年第3期9卷 779-804页

作者： Hang Zhou Bing Liang Haitao Jiang Zhongliang Deng Kexiao Yu Department of Orthopedics The Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing 400010PR China Department of Pathology College of Basic MedicineChongqing Medical University1 Yixueyuan RoadYuzhong DistinctChongqing 400016PR China Department of Orthopedics Chongqing Traditional Chinese Medicine HospitalNo.6 Panxi seventh Branch roadJiangbei DistrictChongqing 400021PR China Institute of Ultrasound Imaging of Chongqing Medical University The Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing 400010PR China

Magnesium(Mg)is the fourth most abundant element in the human body and is important in terms of specific osteogenesis ***,we provide a comprehensive review of the use of magnesium-based biomaterials(MBs)in bone *** review the history of MBs and their excellent biocompatibility,biodegradability and osteopromotive properties,highlighting them as candidates for a new generation of biodegradable orthopedic *** particular,the results reported in the field-specific literature(280 articles)in recent decades are dissected with respect to the extensive variety of MBs for orthopedic applications,including Mg/Mg alloys,bioglasses,bioceramics,and polymer *** also summarize the osteogenic mechanism of MBs,including a detailed section on the physiological process,namely,the enhanced osteogenesis,promotion of osteoblast adhesion and motility,immunomodulation,and enhanced ***,the merits and limitations of current bone grafts and substitutes are *** objective of this review is to reveal the strong potential of MBs for their use as agents in bone repair and regeneration and to highlight issues that impede their clinical ***,the development and challenges of MBs for transplanted orthopedic materials are discussed.

关键词： Magnesium-based biomaterials Bone reconstruction Orthopedic applications future perspectives Clinical transformation

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Progress and prospects of mining with backfill in metal mines in China

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International Journal of Minerals,Metallurgy and Materials 2023年第8期30卷 1455-1473页

作者： Gaili Xue Erol Yilmaz Yongding Wang College of Mining Technology Taiyuan University of TechnologyTaiyuan030024China Research Center of Green Mining Engineering Technology in Shanxi Province Taiyuan030024China Department of Civil Engineering Geotechnical DivisionRecep Tayyip Erdogan UniversityFenerRizeTR53100Turkey Longshou Mine Jinchuan Group Co.Ltd.Jinchuan737100China

Mining is the foundation of modern industrial *** the context of the“carbon peaking and carbon neutrality”era,countries have put forward the development strategy of“adhering to the harmonious coexistence of humans and nature.”The ongoing progress and improvement of filling mining technology have provided significant advantages,such as“green mining,safe,efficient,and low-carbon emission,”which is crucial to the comprehensive utilization of mining solid waste,environmental protection,and safety of *** review paper describes the development history of metal mine filling mining in China and the characteristics of each *** excitation mechanism and current research status of producing cementitious materials from blast furnace slag and other industrial wastes are then presented,and the concept of developing cementitious materials for backfill based on the whole solid waste is *** advances in the mechanical characteristics of cemented backfill are elaborated on four typical levels:static mechanics,dynamic mechanics,mechanical influencing factors,and multi-scale *** working/rheological characteristics of the filling slurry are presented,given the importance of the filling materials conveying ***,the future perspectives of mining with backfill are discussed based on the features of modern filling concepts to provide the necessary theoretical research value for filling mining.

关键词： mining with backfill cementitious materials mechanical characteristics slurry properties future perspectives

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Recent antibacterial agents from biomass derivatives:Characteristics and applications

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Journal of Bioresources and Bioproducts 2024年第3期9卷 283-309页

作者： Nissa Nurfajrin Solihat Alif Faturahman Hidayat R.A.Ilyas Senthil Muthu Kumar Thiagamani Nur Izyan Wan Azeele Fahriya Puspita Sari Maya Ismayati Mohammad Irfan Bakshi Zaharaddeen N.Garba M.Hazwan Hussin Witta Kartika Restu Wasrin Syafii Harits Atika Ariyanta Widya Fatriasari Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Kawasan KST SoekarnoJl Raya Bogor KM 46 Cibinong Bogor 16911Indonesia Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityEspoo 16300Finland Department of Chemical Engineering Faculty of Chemical and Energy EngineeringUniversiti Teknologi MalaysiaJohor 81310Malaysia Centre for Advanced Composite Materials Universiti Teknologi MalaysiaJohor 81310Malaysia Institute of Tropical Forestry and Forest Products Universiti Putra MalaysiaSerdang 43400Malaysia Centre of Excellence for Biomass Utilization Universiti Malaysia PerlisPerlis 02600Malaysia Department of Mechanical Engineering Kalasalingam Academy of Research and EducationKrishnankoil 626126India Institute of Bioproduct Development(IBD) Universiti Teknologi MalaysiaJohor 81310Malaysia Department of Chemistry Ahmadu Bello UniversityZaria 810211Nigeria Materials Technology Research Group(MaTReC) School of Chemical SciencesUniversiti Sains MalaysiaMinden 11800Malaysia Research Center for Chemistry National Research and Innovation Agency(BRIN)Kawasan Puspiptek SerpongSouth Tangerang 15314Indonesia Department of Forest Products Faculty of Forestry and EnvironmentIPB UniversityBogor 16680Indonesia Department of Pharmacy Gunadarma UniversityDepok 16424Indonesia Research Collaboration Center of Biomass-Based Nano Cosmetic In collaboration with National Research and Innovation Agency(BRIN)SamarindaEast KalimantanIndonesia

Enhancing awareness of personal cleanliness and antibacterial resistance has intensified the antibacterial substance request on consumable products. Antibacterial agents that have been commercialized nowadays are produced from inorganic and non-renewable substances. This provides several drawbacks, particularly against health and environmental issues. Therefore, many scientists work on substituting fossil-fuel-based antibacterial agents with natural ones such as from biomass. Biomass derivatives, natural abundances of biopolymers in the world, amount to major compounds including polysaccharides (cellulose, hemicellulose, and chitosan) and polyphenol (tannin and lignin) substances which are capable to combat the growth of Gram-positive bacteria and Gram-negative bacteria. To date, no report focuses on a deep understanding of antibacterial properties derived from biomass and the internal and external factors effects. This work provides that gap because comprehensive knowledge is necessary before applying biomass to the products. The potency of biomass derivatives as antibacterial additives is also summarized. Basic knowledge of antibacterial characteristics to the application in products is highlighted in this review. Besides, the discussion about challenges and future perspectives is also delivered.

关键词： Antibacterial Application Biomass derivatives Challenge future perspectives

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Artificial intelligence for early detection of pancreatic adenocarcinoma: The future is promising

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World Journal of Gastroenterology 2021年第13期27卷 1283-1295页

作者： Antonio Mendoza Ladd David L Diehl Department of Internal Medicine Division of GastroenterologyTexas Tech University Health Sciences Center El PasoEl PasoTX 79905United States Department of Gastroenterology and Nutrition Geisinger Medical CenterDanvillePA 17822United States

Pancreatic ductal adenocarcinoma(PDAC) is a worldwide public health concern. Despite extensive research efforts toward improving diagnosis and treatment, the 5-year survival rate at best is approximately 15%. This dismal figure can be attributed to a variety of factors including lack of adequate screening methods, late symptom onset, and treatment resistance. Pancreatic ductal adenocarcinoma remains a grim diagnosis with a high mortality rate and a significant psychological burden for patients and their families. In recent years artificial intelligence(AI) has permeated the medical field at an accelerated pace, bringing potential new tools that carry the promise of improving diagnosis and treatment of a variety of diseases. In this review we will summarize the landscape of AI in diagnosis and treatment of PDAC.

关键词： Pancreatic adenocarcinoma Artificial intelligence Neural network future perspectives Early diagnosis Improved performance

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Pediatric stricturing Crohn's disease

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World Journal of Gastroenterology 2024年第12期30卷 1651-1654页

作者： Alessandro Boscarelli Matteo Bramuzzo Department of Pediatric Surgery and Urology Institute for Maternal and Child Health-IRCCS“Burlo Garofolo”Trieste 34137Italy Department of Gastrointestinal Endoscopy and Nutrition Institute for Maternal and Child Health-IRCCS"Burlo Garofolo"Trieste 34137Italy

Crohn’s disease(CD)is a chronic inflammatory disease of the digestive *** incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 ***,approximately 25%of children with CD develop stricturing CD(SCD)that requires *** stricturing diseases refractory to pharmacological management frequently require non-pharmacological ***-pharmacological therapeutic strategies include endoscopic balloon dilatation,stricturoplasty,and surgical resection of the strictured ***,strictures tend to recur postoperatively regardless of treatment *** lifetime risk of surgery in patients with childhood SCD remains at 50%-90%.Thus,new and emerging strategies,advanced diagnostic tools,and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.

关键词： Stricturing Crohn’s disease Pediatrics Insights future perspectives

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Latest updates on structure and recommendations of cardiac rehabilitation programs in chronic heart failure

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World Journal of Clinical Cases 2024年第8期12卷 1382-1387页

作者： Christos Kourek Alexandros Briasoulis Dimitrios E Magouliotis John Skoularigis Andrew Xanthopoulos Medical School of Athens National and Kapodistrian University of AthensAthens 15772Greece Department of Clinical Therapeutics Alexandra HospitalFaculty of MedicineNational and Kapodistrian University of AthensAthens 11528Greece Department of Surgery University Hospital of LarissaLarissa 41110Greece of Cardiology University Hospital of LarissaLarissa 41110Greece

Chronic heart failure(HF)is a clinical syndrome with high morbidity and mor-tality *** rehabilitation(CR)is a medically supervised program designed to maintain or improve cardiovascular health of people living with HF,recommended by both American and European guidelines.A CR program con-sists of a multispecialty group including physicians,nurses,physiotherapists,trainers,nutritionists,and psychologists with the common purpose of improving functional capacity and quality of life of chronic HF *** activity,lifestyle,and psychological support are core components of a successful CR *** has been shown to be beneficial in all ejection fraction categories in HF and most patients,who are stable under medication,are capable of *** individualized exercise prescription should be developed on the basis of a baseline evaluation in all *** main modalities of exercise training are aerobic exercise and muscle strength training of different intensity and *** is important to set the appropriate clinical outcomes from the beginning,in order to assess the effectiveness of a CR *** are still significant limitations that prevent patients from participating in these programs and need to be solved.A significant limitation is the generally low quality of research in CR and the presence of negative trials,such as the rehabilitation after myocardial infarction trial,where comprehensive rehabilitation following myocardial infraction had no important effect on mortality,morbidity,risk factors,or health-related quality of life or *** the present editorial,we present all the updated knowledge and recommendations in CR programs.

关键词： Cardiac rehabilitation Heart failure Outcomes Exercise protocols Prescription future perspectives Limitations

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