Magnesium-based biomaterials as emerging agents for bone repair and regeneration:from mechanism to application

作     者：Hang Zhou Bing Liang Haitao Jiang Zhongliang Deng Kexiao Yu Hang Zhou;Bing Liang;Haitao Jiang;Zhongliang Deng;Kexiao Yu

作者机构：Department of OrthopedicsThe Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing 400010PR China Department of PathologyCollege of Basic MedicineChongqing Medical University1 Yixueyuan RoadYuzhong DistinctChongqing 400016PR China Department of OrthopedicsChongqing Traditional Chinese Medicine HospitalNo.6 Panxi seventh Branch roadJiangbei DistrictChongqing 400021PR China Institute of Ultrasound Imaging of Chongqing Medical UniversityThe Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing 400010PR China 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2021年第9卷第3期

页      面：779-804页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：financial support from the National Natural Science Foundation of China(No.81672230) the Natural Science Foundation of Chongqing(No.cstc2020jcyjmsxm2234) the Top-notch Young Talent Project of Chongqing Traditional Chinese Medicine Hospital(No.CQSZYY2020008) the Chongqing Graduate Research Innovation Project(No.CYS20199) 

主　　题：Magnesium-based biomaterials Bone reconstruction Orthopedic applications Future perspectives Clinical transformation 

摘      要：Magnesium(Mg)is the fourth most abundant element in the human body and is important in terms of specific osteogenesis ***,we provide a comprehensive review of the use of magnesium-based biomaterials(MBs)in bone *** review the history of MBs and their excellent biocompatibility,biodegradability and osteopromotive properties,highlighting them as candidates for a new generation of biodegradable orthopedic *** particular,the results reported in the field-specific literature(280 articles)in recent decades are dissected with respect to the extensive variety of MBs for orthopedic applications,including Mg/Mg alloys,bioglasses,bioceramics,and polymer *** also summarize the osteogenic mechanism of MBs,including a detailed section on the physiological process,namely,the enhanced osteogenesis,promotion of osteoblast adhesion and motility,immunomodulation,and enhanced ***,the merits and limitations of current bone grafts and substitutes are *** objective of this review is to reveal the strong potential of MBs for their use as agents in bone repair and regeneration and to highlight issues that impede their clinical ***,the development and challenges of MBs for transplanted orthopedic materials are discussed.