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Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: In vivo and in vitro studies

World Journal of Gastroenterology 2007年第27期13卷 3677-3683页

作者： A Federico A Filippelli M Falciani C Tuccillo A Tiso A Floreani R Naccarato F Rossi C Del Vecchio Blanco C Loguercio Inter-University Research Centre on Foods Nutrition and Gastrointestinal Tract Gastroenterology School 2nd University of Naples Italy Department of Experimental Medicine 2nd University of Naples Italy Department of Surgical and Gastroenterological Sciences University of Padua Italy

AIM: To investigate the relationship among the number of platelets and plasma levels of S-nitrosothiols (S-NO), nitrite, total non-protein SH (NPSH), glutathione (GSH), cysteine (CYS), malondialdehyde (MDA), 4-hydroxininenal (4HNE), tumor necrosis factor-alpha (TNFα) and interleukin (IL)-6 in patients with chronic hepatitis C (CH).METHODS: In vitro the aggregation of platelets derived from controls and CH patients was evaluated before and after the addition of adenosine diphosphate (ADP) and collagen, both in basal conditions and after incubation with nitrosoglutathione (GSNO). RESULTS: In vivo , S-NO plasma levels increased significantly in CH patients and they were significantly directly correlated with platelet numbers. Patients with platelet counts 150 000/μL. In vitro, the ADP and collagen aggregation time was increased in platelets from patients and not from controls; in addition, platelets from CH patients but not from controls also showed a latency time after exposure to collagen. CONCLUSION: The incubation of platelets with GSNO improved the percentage aggregation and abolished the latency time.

关键词： Liver disease function of platelets Hepatitis C Oxidative stress Anti-aggregant

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