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第6届辐射研究与辐射工艺学术年会

作者：朱红平张兆霞赵红卫王文锋姚思德中国科学院上海应用物理研究所

已有的研究结果表明:蛋白质的氧化还原反应与信号转递,基因表达密切相关;抗氧化剂能有效保护和修复ROS 对蛋白质的损伤从而延缓衰老。对抗氧化剂保护和修复蛋白质损伤机理的动态研究具有重要的理论和现实意义。

关键词： antioxidant protein free radical

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Effect of Procyanidins from Pinus koraiensis Bark on Solid Tumor Mice Bearing U14 Cervical Cancer

Effect of Procyanidins from Pinus koraiensis Bark on Solid T...

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2009医学前沿论坛暨第十一届全国肿瘤药理与化疗学术会...

作者： Kun Li,~a Qingwang Li,~(*a,b)Jian Li,~a Dawei Gao,~a Zhengsheng Han,~a a Department of Biological Engineering,College of Environment & Chemical Engineering, Yanshan University,No.438 Hebei street,Qinhuangdao 066004,P.R.China b School of Animal Science,Northwest A&F University,No.22 Xinong Street,Yangling 712100,P.R.China

Pinus koraiensis Bark Procyanidins Extract(PKBPE) has been used in traditional Chinese medicine for thousands of *** this study,we determined PKBPE effect on tumor weight,SOD(superoxidate dismutase) activity,the content of MDA(malondialdehyde) through colorimetric analysis antigenic,and expression of Ki-67,p53 and Bcl-2 on mice bearing U14 cervical *** with PKBPE(158 and 250 mg/kg body weight,p.o.) could inhibit U14 cervical carcinoma growth up to 47.68 and 58.94%.In addition,PKBPE enhance the activity of SOD(pfree radical production inhibition and regulation of the expression of Ki-67,mutant p53 and Bcl-2 protein.

关键词： antitumor activity PKBPE free radical Ki-67 Bcl-2 mutant p53 protein U14 cervical cancer

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INHIBITORY EFFECTS OF VARIOUS TAIWAN TEA EXTRACTS ON CELL DAMAGE IN HYDROGEN PEROXIDE-STIMULATED MSI CELL LINE

INHIBITORY EFFECTS OF VARIOUS TAIWAN TEA EXTRACTS ON CELL DA...

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2005 International Symposium on Innovation in Tea Science and Sustainable Development in Tea Industry

作者： YU-HSING LIN HSUEH-CHUN CHEN CHUI-FENG CHIU CHIH-CHENG LIN Department of Medical Technology Yuanpei University of Science and TechnologyHsinchuTaiwan Department of Food Science Yuanpei University of Science and TechnologyHsinchuTaiwan Yunchih Branch Tea Research and Extension Station Department of Food Science Yuanpei University of Science and TechnologyHsinchuTaiwan

＜正＞The extent to which green and black teas manufactured from Taiwan tea No. 12, with respect to their effects of antioxidant activity and cell viability by H2O2-stimulated MS1 cell line. The total phenolics content of green tea was more than black tea. Relative polymerization of phenolic compound of black tea was higher than green tea. The Trolox equivalent antioxidant capacity and reducing power results indicating that green tea showed a better antioxidant activity. Co-treatment of cells with both teas significantly showed protective effect on cell viability of H2O2-stimulated MS1 cell line. These data suggest that the influence hydrogen peroxide scavenging ability was involved in the protection of H2O2-stimulated MS1 cell line by teas polyphenolics.

关键词： Black tea free radical Green tea Hydrogen peroxide MS1 cell line

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Food Irradiation and Detection of Irradiated Food Containing Cellulose

Food Irradiation and Detection of Irradiated Food Containing...

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2007中国科协年会

作者： Wan Xiaojuan Jiao Zheng~* Zheng Jianfei Wang Haobo Xu Gang Applied Radiation Institute of Shanghai University,Shanghai 201800,China

The development of food irradiation technology at home and abroad is *** the fast development and great application of food irradiation technology,the need for analysis and identification of irradiated food become *** can be used to detect the irradiated food containing *** in the market,dried chili powder,dried peanuts and fresh strawberries,were chosen to be irradiated by controlled amounts about 0.5-10 kGy of Co gamma *** ESR spectra were measured to study the relation between ESR signal intensity and irradiation ***,establishing ESR standard database is put forward,to regulate food irradiation behavior,to improve food safety level,and to get rid of new trade technical barriers of developed countries.

关键词： ESR hTadiation dose free radical

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口服PTD-SOD和SOD对关节炎大鼠的影响(英文)

口服PTD-SOD和SOD对关节炎大鼠的影响(英文)

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华东六省一市生物化学与分子生物学会2008年学术交流会

作者：叶南慧刘树滔饶平凡福州大学生物工程研究所

Rheumatoid arthritis (RA)is a chronic autoimmunity disease which shows synovitis. The activity of SOD in RA patient is reduced,which attenuated the ability to clear free *** performed animal experiments to test the effect of the superoxide dismutase(SOD)and the fusion protein(PTD-SOD)consisting of a SOD linked to a protein transduction domain(TAT)in RA *** experimented animal model of adjuvant arthritis rats was established by injection of complete Freund’s adjuvant at ankle *** normal saline,SOD or PTD-SOD into stomach respectively to different *** body weight,hind paw edema were monitored during the *** the end of experiments,we acquired blood form orbit of rats which was used to assay the level of the SOD,GSH-PX、CAT、MDA and *** arthritic control rats showed significant increases in paw volume as a result of the adjuvant injection into the *** the next week,the inflammation had been significant remitted in SOD group and TAT-SOD *** major biomakers fell back to normal among the SOD group and PTD-SOD group,and the effect with the latter was better than the *** conclusion,oral administration of SOD or TAT-SOD reduced the size of paw inflammatory edema and resulted in the levels of serum antioxidants including SOD,*** back to the normal,indicating that SOD,and especially PTD-SOD can be effective in RA treatment.

关键词： TAT-SOD Arthritis Rats Adjuvant free radical

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Oxidative stress and neurodegenerative diseases

Oxidative stress and neurodegenerative diseases

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Bao-Lu ZHAO State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Academia Sinica,Beijing 100101,China

There is a common character for neurodegenerative diseases:all of them are connected with oxidative stressinduced neuronal *** free radical results in biological injure *** radicals peroxidize membrane lipids and oxidize proteins,resulting in damage of plasma membrane and cross-linking of cytoskeletal *** stress, an imbalance toward the prooxidant side of the prooxidant/antioxidant homeostasis,occurs in several brain neurodegenerative *** these neurodegenerative brain disorders are those in which protein aggregation is observed in hippocampus of AD brain and in substantia nigra of PD *** are usually expected as scavengers of free *** we demonstrated that antioxidants could protect cells and rat against neurotoxicities caused by 6-OHDA through ROS and NO free *** investigated the effects of exposure of cells and rat to 6-OHDA alone or associated with pre-treatment of Tea catechins(TC).Exposure of cells and rats to 6-OHDA induced a concentrationdependent apoptosis observed by flow cytometry,fluorescence microscopy and DNA fragmentation *** displayed significantly inhibitory effects against the cell death and protection the rats from Parkinson’s *** also showed good protective effect of TC on rat against Parkinson’s diseas model caused by *** neuroprotective effect of soy isoflavone against Aβ-induced apoptosis in cultured hippocampal neurons was *** was found that Aβ-induced apoptosis,indicated by Aβdecreased cell viability,neuronal DNA condensation and fragmentation,is associated with the increase of intracellular free Ca level,the accumulation of ROS,and the activation of *** these phenotypes induced by Aβare reverted by soy *** results further show that at nanomolar level, genistein protects neurons from Aβ-induced damages mainly via the estrogen receptor(ER)-mediated pathway and at micromolar level,the neuroprotective effect of soy is

关键词： oxidative stress free radical natural antioxidants

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聚乳酸/生物基聚氨酯弹性体的自由基反应共混研究

聚乳酸/生物基聚氨酯弹性体的自由基反应共混研究

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2014年全国高分子材料科学与工程研讨会

作者：张立生张若愚朱锦中科院宁波材料技术与工程研究所

＜正＞聚乳酸是一种来源于淀粉的生物可降解高分子材料,具有优异的力学性能、加工性能以及生物相容性,但是聚乳酸也有韧性差、冲击强度低的缺点,这严重限制了其应用领域1。与韧性高分子（橡胶相）共混是解决聚乳酸韧性差的常用方法,但... 详细信息

＜正＞聚乳酸是一种来源于淀粉的生物可降解高分子材料,具有优异的力学性能、加工性能以及生物相容性,但是聚乳酸也有韧性差、冲击强度低的缺点,这严重限制了其应用领域1。与韧性高分子（橡胶相）共混是解决聚乳酸韧性差的常用方法,但是高分子共混体系往往是热力学不相容的,需要加入相容剂来提高两相的相容性。反应共混可以在熔融共混过程中原位生成相容剂,是一种提高高分子共混物界面相容性的方便、有效的方法2。文献报道了许多聚

关键词： Polylactide Reactive blending free radical Bio-based thermoplastic elastomer Toughness

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Effect of Shengmaisan（生脉散）on Lipid Peroxidation Damage in Acute Myocardial infarctionPatients

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Chinese Journal of Integrative Medicine 1996年第4期2卷 249-251页

作者：吕宝经荣烨之赵美华黄国芳朱向阳杨瑾文

The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients, 30 anginapectoris and 68 acute myocardial infarction (AMI) and its peroxidation damage was studied. It was shownthat the activities of superoxide dismutase (SOD) and glutathione peroxidase ( GSH-Px) in blood decreasedand the content of malondialdehyde (MDA) in plasma increased in CHD patients in comparison with thehealthy controls (P 0. 05 ) . It could be assumed that the pathogenesis of CHD is associated withfree radical (FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effectivefree radical scavenger, which would ameliorate the lipid peroxidation damage . Thus, SMS could be adminis-tered in the prevention and the treatment of CHD.

关键词： Shengmaisan acute myocardial infarction free radical lipid peroxidation

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The Clinical analyse of 206 patients of cerebral infarction (Abstract)

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中国临床神经科学 2000年第Z1期8卷 61-页

作者： Mai Mai Ti Yi Ming Ghen Bo The Second People' s Hospital Kashi Xinjiang China The Second People' s Hospital Kashi Xinjiang China The Second People' s Hospital Kashi Xinjiang China

　　This thesis make a summary and analyse to 206 patients of cerebral infarction. The morbidity of the age from 51 to 70 is thehighist in 206 patients. It is 75.3 % a mong the patient that hypertension is original. The frequently-occurring cerebral in farction patient are 36.8 % and it is the highist. Because our hospital have purchased CT machinery, we can early diagnose cerebral infarction and do dissolving thrombus in early time, controlling blood pressure, clearing away free radical, dehydrating, di lating cerebral blood vessel, recovering treat early and so on. It reduced the appear ing of conplication and the death rate and viability by oneselfare improved obvious lv.

关键词： cerebral infarction blood pressure free radical blood vessel death rate

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Effects of melatonin on mitochondria after cerebral isehemic reperfusion

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中国临床神经科学 2000年第Z1期8卷 79-页

作者： Wang Hongyu Department of Neurology.Hospital of Zhou Kou District He New

　　Melatonin has been regarded as a free radical scavenger and antioxidant. In both in vitro and in vivo experiments. Melatonin was found to protect cells, tissues and organs against oxidative damage induced by a variety of free radical generating agents and processes, e.g., ischemic reperfusion. The mechanisms underlying these interactions have not been defined. The goal of the present study was to observe the effects of melatonin on rnitochondria after cerebral ischemic reperfusion and the mechanisms of neuroprotection of melatonin by gerbil ischemic model. Male Mongolian gerbils were subjected to 10 min of forebrain ischemia by occlusion of both common carotid arteries under anesthesia. Melatonin(0.8 mg/kg) was administrated intraperitoneum 30 min befbre arteries occlusion. We measured the respiratory function of mitochondria, the activities of ATPase, the free mitochondrial calcium contents and the GSH level of mitochondria. The results show that oxidative phosphorylation function of mitochondria was damaged after cerebral ischemic reperfusion. And mitochondrial calcium was overloaded after cerebral ischemic reperfusion. And the level of GSH in mitochondria decreased after cerebral ischemic reperfision. It is concluded that melatonin have neuroprotection effects after cerebral ischemic repertusion and this effects probably related to the protection mitochondria.

关键词： oxidative phosphorylation free radical respiratory function radical scavenger Mongolian gerbils in vitro

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