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Experimental Study of Yishou Tiaozhi Tablet(益寿调脂片) on free radical Metabolism in Aging Model Mice

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Chinese Journal of Integrative Medicine 2000年第4期6卷 283-286页

作者：朱秉匡孙立郑仕富张荣华 The First Hospital of Medical College Jinan University Medical College Jinan University

Objective： To observe the effect of Yishou Tiaozhi tablet（YSTZT） on the metabolism of free radical in mice of aging model. Methods: Using the aging model induced by hypodermic injection of 5%D-glalactose in mice for forty days. The content of malondialdehyde(MDA) and activity of superoxide dismutase(SOD), glutathione peroxidase (GSH-Px) in serum, activity of monoamine oxidase B (MAO-B), Na+-K+-ATPase in brain were investigated after treatment. Results: Compared with the aging model group, it showed that YSTZT could obviously inhibit the increase of level of MDA in serum and the activities of MAO-B in brain; and enhance the activities of SOD,GSH-Px in serum, and the activities of Na+-K+-ATPase in brain. Furthermore, YSTZT could obviously elevate the tolerance to fatigue and hypoxia in mice. Conclusion: YSTZT could effectively improve the free radical metabolism of senile body, it is an ideal and effective medicine in preventing aging, which is also one of the experimental basis in proving the theory of 'Spleen and Kidney Deficiency complicated with Stasis and Phlegm causes aging'.

关键词： Yishou Tiaozhi tablet aging model free radical

radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research(International) 2024年第6期31卷 1355-1366页

作者： Sheng-hao Li Ao Huang Fan-bo Zeng Hui Peng Hao-ran Wei Xue-chun Huang Sheng-qiang Song Hua-zhi Gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting free radical

free radicals induced ultra-rapid synthesis of N-doped carbon sphere catalyst with boosted pyrrolic N active sites for efficient acetylene hydrochlorination

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Nano Research 2023年第5期16卷 6178-6186页

作者： Yuxiang Bao Xiuhui Zheng Jianlin Cao Shuo Li Yongxiao Tuo Xiang Feng Mingyuan Zhu Bin Dai Chaohe Yang De Chen State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580China Department of Chemical Engineering Norwegian University of Science and TechnologyTrondheim 7491Norway School of Chemistry and Chemical Engineering of Shihezi University Shihezi 832000China College of Chemistry&Chemical Engineering of Yantai University Yantai 264005China

Activated carbon-supported HgCl2 catalysts have seriously impeded the development of the polyvinyl chloride(PVC)industry due to the sublimation of Hg species and environmental pollution ***,the template-free and organic solvent-free strategy was devised to synthesize non-metallic based nitrogen-doped carbon(U-NC)sphere catalyst for acetylene *** green strategy via ultrasonic chemistry initiates resin crosslinking reactions between aminophenol and formaldehyde resin by free radicals,leading to the ultra-rapid formation of U-NC with remarkably high pyrrolic N content in only 5 *** U-NC catalyst exhibited an outstanding space-time-yield(1.6 gVCM·gcat^(−1)·h^(−1)),even comparable to the reported metallic *** combining kinetic analysis,advanced characterizations,density functional theory,it is found that the amount of pyrrolic N is in linear with C_(2)H_(2)conversion,pyrrolic N in U-NC can effectively improve acetylene hydrochlorination performance by mediating HCl *** work sheds new light on rationally constructing metal-free catalyst for acetylene hydrochlorination.

关键词： acetylene hydrochlorination nitrogen-doped carbon ultrasonic chemistry free radical polymerization

In Vitro Antioxidant and Radio Protective Activities of Lycopene from Tomato Extract against Radiation—Induced DNA Aberration

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Journal of Biosciences and Medicines 2024年第2期12卷 202-213页

作者： Safaiatul Islam Abu Hena Mostofa Kamal Md. Ziaur Rahman Protul Kumar Roy A.Y.K. Md. Masud Rana Molecular Radiobiology and Biodosimetry Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Savar Bangladesh

Background: The accumulation of free radicals is linked to a number of diseases. free radicals can be scavenged by antioxidants and reduce their harmful effects. It is therefore essential to look for naturally occurring antioxidants that come from plants, as synthetic antioxidants are toxic, carcinogenic and problematic for the environment. Lycopene is one of the carotenoids, a pigment that dissolves in fat and has antioxidant properties. Materials and Methods: The antioxidant and free radical scavenging activity were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The impact of lycopene on bacteria (E. coli) susceptibility to γ-radiation was examined by radio sensitivity assay. The study also examined the induction of strand breaks in plasmid pUC19 DNA and how lycopene extract protected the DNA from γ-radiation in vitro. Results: At varying concentrations, lycopene demonstrated its ability to scavenge free radicals such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). IC50 for lycopene was determined at 112 μg/mL which was almost partial to IC50 of standard antioxidant L-ascorbic acid. The D10 value 180 Gy of E. coli was found to be >2-fold higher in the extract-containing lycopene sample than in the extract-free controls. The lycopene extracts inhibited the radiation-induced deterioration of the plasmid pUC19 DNA. At an IC50 concentration, lycopene provided the highest level of protection. Conclusion: Lycopene functions as an efficient free radical scavenger and possible natural antioxidant source. For cancer patients and others who frequently expose themselves to radiation, lycopene may be a useful plant-based pharmaceutical product for treating a variety of diseases caused by free radicals.

关键词： Radio Protective Antioxidants free radical DNA Damage pUC19 Plasmid Gamma Irradiation DPPH

ESR STUDY OF free radicalS IN IRRADIATED POLYAMIDE-1010

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Chinese Journal of Polymer Science 1993年第1期11卷 46-53页

作者：周茂堂张利华刘雅言陈东霖 Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022

Polyamide-1010 samples were irradiated in vacuum at room temperature by Cobalt-60 γ-rays. The free radicals formed in irradiation were studied by means of electron spin resonance (ESR)*** ESRspectra consisted of a quartet and a superimposed singlet which were attributed to radical -CO-NH-CH-CH_2 and -CH_2-C=O, respectively. The effects of temperature and crystaUinity on the radicals were discussed and the mechanism for the production and decay of the radicals was also proposed.

关键词： ESR Radiation Polyamide free radical

Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction

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Neural Regeneration Research 2012年第19期7卷 1469-1474页

作者： Weihui Huang Yadan Li Yufeng Lin Xue Ye Dawei Zang Department of Neurology Tianjin First Center HospitalTianjin Medical UniversityTianjin 300192China

The present study established a mouse model of cerebral infarction by middle cerebral artery occlusion, and monitored the effect of 25 tJg/kg leukemia inhibitory factor and （or） basic fibroblast growth factor administration 2 hours after model establishment. Results showed that following administration, the number of endogenous neural stem cells in the infarct area significantly increased, malondialdehyde content in brain tissue homogenates significantly decreased, nitric oxide content, glutathione peroxidase and superoxide dismutase activity significantly elevated, and mouse motor function significantly improved as confirmed by the rotarod and bar grab tests. In particular, the effect of leukemia inhibitory factor in combination with basic fibroblast growth factor was the most significant. Results indicate that leukemia inhibitory factor and basic fibroblast growth factor can improve the microenvironment after cerebral infarction by altering free radical levels, improving the quantity of endogenous neural stem cells, and promoting neurological function of mice with cerebral infarction.

关键词： leukemia inhibitory factor basic fibroblast growth factor endogenous neural stem cells free radical malondialdehyde nitric oxide glutathione peroxidase superoxide dismutase neuroprotection

Antioxidant activity of Cat's whiskers flavonoid on some reactive oxygen and nitrogen species generating inflammatory cells is mediated by scavenging of free radicals

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中国天然药物 2012年第5期10卷 321-327页

作者： Asis Bala Biswakanth Kar Indrajit Karmakar R.B. Suresh Kumar Pallab Kanti Haldar Department of Pharmaceutical Technology Jadavpur University Department of Pharmacology Himalayan Pharmacy Institute Majhitar Rangpo

AIM: To find out the effect of Cat's whiskers (Cleome gynandra L., Capparidaceae) flavonoid (CWF) for the scavenging of free radicals in some inflammatory cells. METHODS: Mouse erythrocyte's hemoglobin, peritoneal macrophage, and peripheral blood lymphocytes were oxidized either by some of toxic chemicals (nitrite, carbon tetrachloride) or by enzymatic stimulation (glu- coseoxidase) to produce oxidative damage to cells. The protective effect of the CWF was examined, and the biochemical mechanism of action was also investigated in terms of the scavenging of free radicals. RESULTS: CWF (1 20 μg mL 1 ) decreased glucoseoxidase and nitrite induce oxidative damage in a concentration dependent manner in an in vitro model and inhibited the lysis of RBC [(28.64 ± 13.03)% and (70.31 ± 1.80)%] when mice were treated with CWF (25 and 50 mg kg 1 ). To assess the antioxidant potential of CWF in the lymphocytes and macrophages in living animals, the effect of CWF was measured on the elevated level of superoxide anions production in the cells. CWF scavenged the superoxide anion (O 2 ) production and inhibited the O 2 induced destruction of protein and lipid biomolecules. CONCLUSION: The study has established that the CWF mediates its antioxidant activity in some chronic inflammatory cells via its free radical scavenging activity.

关键词： Cleome gynandra Cat’s whiskers Flavonoid Inflammatory cells free radical Scavenging

Lower blood malondialdehyde is associated with past pesticide exposure:findings in Gulf War illness and healthy controls

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Military Medical Research 2022年第2期9卷 205-214页

作者： Beatrice Alexandra Golomb Sridevi Devaraj Alexis K.Messner Hayley Jean Koslik Jun Hee Han Barnabas Yik Department of Medicine School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Swedish Medical Center SeattleWA 98109USA Henry M.Jackson Foundation for the Advancement of Military Medicine San DiegoCA 92134USA Santa Clara Valley Medical Center San JoseCA 95128USA

Background: Malondialdehyde(MDA) is a candidate general marker of oxidative stress(OS). We sought to assess the relation of MDA to Gulf War illness(GWI) and to a variety of ***: This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific ***: Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower MDA level in veterans with ***: Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.

关键词： Malondialdehyde Oxidative stress free radical Gulf War veterans Gulf War illness Pesticide

Critical review of perovskites-based advanced oxidation processes for wastewater treatment: Operational parameters, reaction mechanisms,and prospects

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Chinese Chemical Letters 2022年第2期33卷 643-652页

作者： Ruicheng Ji Jiabin Chen Tongcai Liu Xuefei Zhou Yalei Zhang State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Key Laboratory of Yangtze Water Environment for Ministry of Education College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China

In the field of advanced oxidation processes(AOPs) of wastewater, many materials can be used as heterogeneous catalysts. The role of these catalysts is to activate oxidants and generate reactive oxygen species(ROS) to decompose refractory pollutants. Perovskite oxide, an emerging catalyst in the field of AOPs, has been extensively studied in wastewater treatment. Nevertheless, the application of perovskite in AOP systems still faces some problems, such as leaching of metal ions, a small surface area, a low number of active sites, etc. Herein, this critical review comparatively examines the activation mechanisms of peroxymonosulfate, hydrogen peroxide, and peroxydisulfate. Furthermore, the formation pathways of oxidizing species based on recent advances in experimental and theoretical studies were evaluated. In addition, the impacts of water parameters and constituents such as initial p H, oxidant concentration, catalyst dosage,natural organic matter, halide, phosphate, and carbonate were discussed. Finally, a critical discussion and prospects of mechanism exploration and possible materials development are proposed to confront the existing challenges in the application of perovskite oxides in AOPs.

关键词： Perovskite Advanced oxidation processes Wastewater Peroxide free radical