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forkhead box m1 transcription factor:a novel target for pulmonary arterial hypertension therapy

World Journal of Pediatrics 2020年第2期16卷 113-119页

作者： Li Gu Han-min Liu Department of Pediatric Pneumology West China Second University HospitalSichuan UniversityChengduChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationWest China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadWuhou DistrictChengduChina

Background forkhead box m1(Foxm1),a member of forkhead family,plays a key role in carcinogenesis,progression,invasion,metastasis and drug *** on the similarities between cancer and pulmonary arterial hypertension,studies on the roles and mechanisms of Foxm1 in pulmonary arterial hypertension have been *** article aims to review recent advances in the mechanisms of signal transduction associated with Foxm1 in pulmonary arterial *** sources Articles were retrieved from Pubmed and mEDLINE published after 1990,including-but not limited to Foxm1 and pulmonary arterial *** Foxm 1 is overexpressed in pulmonary artery smooth muscle cells in both pulmonary arterial hypertension patients and animal models,and promotes pulmonary artery smooth muscle cell proliferation and inhibits cell apoptosis via regulating cell cycle *** signaling molecules and pathways,including hypoxia-inducible factors,transforming growth factor-β/Smad,SET domain-containing 3/vascular endothelial growth factor,survivin,cell cycle regulatory genes and DNA damage response network,are reported to cross talk with Foxm1 in pulmonary arterial *** inhibitors are effective in the prevention and treatment of pulmonary arterial hypertension by inhibiting the expression and transcriptional activity of *** Foxm1 has a crucial role in the pathogenesis of pulmonary arterial hypertension and may represent a novel therapeutic *** more details of interaction between Foxm1 and other signaling pathways need to be clarified in the future.

关键词： forkhead box m1 Proteasome inhibitor Pulmonary arterial hypertension Signaling pathway

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Clinical implications of forkhead box m1, cyclooxygenase-2, and glucose-regulated protein 78 in breast invasive ductal carcinoma

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World Journal of Clinical Cases 2023年第30期11卷 7284-7293页

作者： Jie Bai Ying Li Li Cai Department of Clinical Laboratory Joint Logistics Support Unit 940 HospitalLanzhou 730030Gansu ProvinceChina Department of Breast Surgery The Fourth Hospital of ShijiazhuangShijiazhuang 050032Hebei ProvinceChina Department of Pathology Huai’an Maternal and Child Health Care CenterHuai’an 223002Jiangsu ProvinceChina

BACKGROUND Breast infiltrating ductal carcinoma(BIDC)represents the largest heterotypic tumor group,and an in-depth understanding of the pathogenesis of BIDC is key to improving its *** To analyze the expression profiles and clinical implications of forkhead box m1(FOXm1),cyclooxygenase-2(COX-2),and glucose-regulated protein 78(GRP78)in *** A total of 65 BIDC patients and 70 healthy controls who presented to our hospital between August 2019 and may 2021 were selected for *** peripheral blood FOXm1,COX-2,and GRP78 levels in both groups were measured and the association between their expression profiles in BIDC was ***,we investigated the diagnostic value of FOXm1,COX-2,and GRP78 in patients with BIDC and their correlations with clinicopathological ***,BIDC patients were followed for 1 year to identify factors influencing patient *** The levels of FOXm1,COX-2,and GRP78 were significantly higher in BIDC patients compared to healthy controls(Pmong them(Pmonstrated that FOXm1,COX-2,and GRP78 had excellent diagnostic value in predicting the occurrence of BIDC(Pm1,COX-2,and GRP78 levels among patients with different histological grades and metastasis statuses(with vs without)(Pm1,COX-2,GRP78,increased histological grade,and the presence of tumor metastasis were independent risk factors for prognostic death in BIDC(P1).CONCLUSION FOXm1,COX-2,and GRP78 exhibit abnormally high expression in BIDC,promoting malignant tumor development and closely correlating with *** findings hold significant research implications for the future diagnosis and treatment of BIDC.

关键词： Diagnostic value forkhead box m1 Cyclooxygenase-2 Glucose-regulated protein 78 Clinical implications

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Down-regulation of Foxm1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence

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World Journal of Gastroenterology 2014年第28期20卷 9497-9505页

作者： Jie Tao Xin-sen Xu Yan-zhou song Kai Qu Qi-fei Wu Rui-Tao Wang fan-di meng Ji-chao Wei shun-bin dong Yue-lang zhang min-hui Tai Ya-feng dong Lin Wang Chang liu Department of Hepatobiliary Surgery the First Affiliated Hospital of Medical CollegeXi’an Jiaotong University Department of General Surgery Lianyungang First People’s Hospital Department of Thoracic Surgery the First Affiliated Hospital of Medical CollegeXi’an Jiaotong University Department of Obstetrics and Gynecology University of Kansas School of Medicine

AIm: To investigate the effect of knockdown of forkhead box m1 (Foxm1) on the proliferation and invasion capacities of human gallbladder carcinoma (GBC)-SD cells.

关键词： forkhead box m1 Gallbladder carcinoma Senescence Viability Invasion

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FOXm1通过靶向上调PHB2的转录改善线粒体功能障碍保护脂多糖诱导的肾小管上皮细胞损伤

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河北医学 2022年第3期28卷 368-374页

作者：陈娟陈拉斯陈丽唐文庄张琼果王善志海南医学院第一附属医院海南海口570000

目的:探究FOXm1在脂多糖(LPS)诱导的肾小管上皮细胞损伤中的作用及其可能的作用机制。方法:体外培养人肾小管上皮细胞HK-2,qRT-PCR和Western blot检测细胞FOXm1和PHB2表达;CCK-8检测细胞活力;流式细胞术检测细胞凋亡;JC-1染色检测线粒... 详细信息

目的:探究FOXm1在脂多糖(LPS)诱导的肾小管上皮细胞损伤中的作用及其可能的作用机制。方法:体外培养人肾小管上皮细胞HK-2,qRT-PCR和Western blot检测细胞FOXm1和PHB2表达;CCK-8检测细胞活力;流式细胞术检测细胞凋亡;JC-1染色检测线粒体膜电位;试剂盒检测细胞ATP含量;荧光素酶报告实验和ChIP-PCR实验检测FOXm1对PHB2启动子调控作用。结果:与对照组相比,LPS组细胞中FOXm1和PHB2表达、细胞活力、红/绿荧光强度比值和ATP含量明显降低(Pm1和PHB2表达、细胞活力、红/绿荧光强度比值、ATP含量和细胞凋亡率差异无统计学意义(P>0.05);与LPS+oe-NC组相比,LPS+oe-FOXm1组细胞中FOXm1和PHB2表达、细胞活力、红/绿荧光强度比值和ATP含量明显升高(Pm1靶向结合PHB2启动子区域。与LPS+oe-NC+sh-NC组相比,LPS+oe-FOXm1+sh-NC组细胞中FOXm1和PHB2蛋白表达、细胞活力、红/绿荧光强度比值和ATP含量明显升高(Pm1蛋白表达差异无统计学意义(P>0.05);sh-PHB2可部分逆转oe-FOXm1对LPS处理的HK-2细胞的作用。结论:FOXm1通过靶向结合PHB2启动子区域促进PHB2表达,改善线粒体功能障碍,从而抑制LPS诱导的肾小管上皮细胞损伤。

关键词：肾小管上皮细胞脂多糖 forkhead box m1 prohibitin 2 线粒体

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