Forkhead box M1 transcription factor:a novel target for pulmonary arterial hypertension therapy

作     者：Li Gu Han-Min Liu Li Gu;Han-Min Liu

作者机构：Department of Pediatric PneumologyWest China Second University HospitalSichuan UniversityChengduChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationWest China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadWuhou DistrictChengduChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2020年第16卷第2期

页      面：113-119页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Forkhead box M1 Proteasome inhibitor Pulmonary arterial hypertension Signaling pathway 

摘      要：Background Forkhead box M1(FoxM1),a member of forkhead family,plays a key role in carcinogenesis,progression,invasion,metastasis and drug *** on the similarities between cancer and pulmonary arterial hypertension,studies on the roles and mechanisms of FoxM1 in pulmonary arterial hypertension have been *** article aims to review recent advances in the mechanisms of signal transduction associated with FoxM1 in pulmonary arterial *** sources Articles were retrieved from PubMed and MEDLINE published after 1990,including-but not limited to FoxM1 and pulmonary arterial *** FoxM 1 is overexpressed in pulmonary artery smooth muscle cells in both pulmonary arterial hypertension patients and animal models,and promotes pulmonary artery smooth muscle cell proliferation and inhibits cell apoptosis via regulating cell cycle *** signaling molecules and pathways,including hypoxia-inducible factors,transforming growth factor-β/Smad,SET domain-containing 3/vascular endothelial growth factor,survivin,cell cycle regulatory genes and DNA damage response network,are reported to cross talk with FoxM1 in pulmonary arterial *** inhibitors are effective in the prevention and treatment of pulmonary arterial hypertension by inhibiting the expression and transcriptional activity of *** FoxM1 has a crucial role in the pathogenesis of pulmonary arterial hypertension and may represent a novel therapeutic *** more details of interaction between FoxM1 and other signaling pathways need to be clarified in the future.