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Effect of Integrated Chinese and Western Medicine Therapy on Severe Hand, foot and mouth disease: A Prospective, Randomized, Controlled Trial

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Chinese Journal of Integrative Medicine 2017年第12期23卷 887-892页

作者： LI Xiu-hui LI Shuang-jie XU Yi WEI Dan SHI Qing-sheng ZHU Qing-xiong YANG Tong DING Jian-bo TIAN Yi-mei HUANG Ji-han WANG Kun WEN Tao ZHANG Xi Department of Integrated Traditional Chinese Medicine and Western Medicine Beijing Youan Hospital Affiliated to Capital Medical University Department of Communicable diseases Children's Hospital of Hunan Province Department of Pediatrics Guangzhou Medical Center for Women and Children Department of Pediatrics First Hospital Affiliated to Guangxi Medical University Department of Internal Medicine Handan Maternal and Child Health Hospital Department of Internal Medicine Children's Hospital of Jiangxi Province Department of Pediatrics The People's Hospital of Liuzhou Center for Drug Clinical Research Shanghai University of Chinese Medicine Medical Research Center Beijing Chaoyang HospitalCapital Medical University Department of Pediatrics Kaifeng Children's Hospital

Objective: To evaluate the efficacy and safety of Chinese medicine(CM) plus Western medicine(WM) in the treatment of pediatric patients with severe hand, foot and mouth disease(HFMD) by conducting a prospective, controlled, and randomized trial. Methods: A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone(224 cases, WM therapy group) or CM [Reduning Injection(热毒宁注射液) or Xiyanping Injection(喜炎平注射液)] plus WM therapy(227 cases, CM plus WM therapy group) for 7–10 days, according to a web-based randomization system. The primary outcome was fever clearance time, which was presented as temperature decreased half-life time. The secondary outcomes included the rate of rash/herpes disappearance within 120 h, as well as the rate for cough, runny nose, lethargy and weakness, agitation or irritability, and vomiting clearance within 120 h. The drug-related adverse events were also recorded. Results: The temperature decreased half-life time was 40.4 h in the WM therapy group, significantly longer than 27.2 h in the CM plus WM therapy group(P<0.01). Moreover, the rate for rash/herpes disappearance within 120 h was 43.6%(99/227) in the CM plus WM therapy group, significantly higher than 29.5%(66/224) in the WM therapy group(P<0.01). In addition, the rate for cough, lethargy and weakness, agitation or irritability disappearance within 120 h was 32.6%(74/227) in the CM plus WM therapy group, significantly higher than 19.2%(43/224) in the WM therapy group(P<0.01). No drug-related adverse events were observed during the course of the study. Conclusions: The combined CM and WM therapy achieved a better therapeutic efficacy in treating severe HFMD than the WM therapy alone. Reduning or Xiyanping Injections may become an important complementary therapy to WM for relieving the symptoms of severe HFMD.

关键词： hand foot and mouth disease Reduning Injection Xiyanping Injection Chinese medicine

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A randomized controlled clinical study on treatment of hand, foot and mouth disease in children with Reduning injection

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Chinese Medical Journal 2013年第13期126卷 2585-2586页

作者： XU Hua-shan ZHUO Zhi-qiang CHEN Bao-chuan J1NG Jiao ZHAO Guo-rong WU Jun-feng XIAO Wei Quanzhou Children's Hospital Teaching Hospital of Fujian Medical University Quanzhou Fujian 362000 China Jiangsu Kangyuan Pharmaceutical Corporation Ltd. Lianyungang Jiangsu 22200 I China

Hand, foot and mouth disease （HFMD） has become a major public health problem in China since 2008,which has been widely prevalent in children under 5 years of age. According to the data of the Ministry of Health, the number of cases with HFMD exceeded 1 million during the recent 4 years. The major etiologic agent of HFMD is enterovirus 71 and coxsackievirus A 16. The main clinical manifestations of the disease include fever, maculopapular skin vesicles on the hand, foot and buttock, oral herpes, ulcer; ation severe cases there can be central nervous system infection and/or pulmonary hemorrhage, which are mostly caused by EV71 and may be life-threatening with a fatality rate of 0.3 to 0.5 per thousand cases. There are no specific antiviral drugs, nor vaccine against EV71.~ The difficult problem of the treatment is how to reduce the severe cases and mortality. Reduning injection is a preparation of traditional Chinese herbal medicine composed of Qinghao （Artemisiae annuae）, Jinyinhua （Flos lonicerae） and Zhizi （Gardenia jasminoides）, which was listed among the therapies for HFMD in the 2010 guidelines of the Ministry of Health for diagnosis and treatment of HFMD.2 We now reported the results of our study on the efficacy of Reduning injection in treatment of 81 patients with HFMD. We selected 81 cases who were inpatients treated in 2010 in the Department of Infectious diseases of Quanzhou Chidren＇s Hospital. The inclusion criteria were as follows： 1. Patients who met either the clinical diagnostic criteria for HFMD ordinary clinical type or the clinical diagnostic criteria for confirmed cases of HFMD （etiologically confirmed cases must account for more than 1/3 of the cases）. 2. The axillary temperature is _〉37.5~C, within 48 hours after onset of the disease; 3. Skin changes such as the rashes and vesicles occurred in no more than 48 hours; 4. Range of age is between 1 and 13 years; 5. Patients or their parents or guardians are willing to participate in the study and si

关键词： hand foot and mouth disease Reduning injection children

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Results on Pathogen Detection of foot and mouth disease in Guangxi China and Analysis on Its Popular Spectrum

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Journal of Biosciences and Medicines 2016年第5期4卷 98-104页

作者： Shanqiu Wei Wenyi Dong Guosheng Su Qiuying Ma Shunda Luo Zuyan Ni The Fourth People’s Hospital Clinical Laboratory Nanning China Nanning Guangxi AIDS Clinical Treatment Center Naning China Nanning Infectious disease Hospital Affiliated to Guangxi Medical University Naning China

Objective: The study aims to understand the characteristics and epidemic trend of the pathogen of hand, foot and mouth disease (HFMD) in Guangxi regions, China. Besides, it aims to analyze the differences of intestinal virus detection rate between anal swab and pharyngeal swab samples. Methods: Anal swab and pharyngeal swabs of suspected HFMD children were collected in our hospital from 2012 to 2015. Real-time fluorescent PCR (Polymerase Chain Reaction) was used to detect enterovirus 71 (EV71), coxsackie virus type 16 (CA16), and universal intestinal virus nucleic acid (EV). Composition and conversion of predominant pathogens were analyzed, and paired samples’ test results of swabs anal and pharyngeal swab were statistically analyzed. Results: There are 681 cases with enterovirus in 2351 cases of patients. Among those who got enterovirus, there are 501 cases of EV71, 102 cases of CA16 and 79 cases of EV. From 2012 to 2015, the total proportion of the virus detection is 46.47%, 16.23%, 41.02% and 15.33% respectively in each year, while the proportion of predominant epidemic virus is 93.93% of EV71, 66.12% of CA16, 89.30% of EV71 and 98.73% of EV, non-EV71, non-CA16 EV (from October to December in 2015). It’s obvious that the total virus detection rate in 2012 and 2014 is significantly higher than that in 2013 and 2015. There is statistical significance. Conclusion: The main HFMD pathogens are EV71 from 2012 to 2015 in Guangxi regions. In 2012 and 2014, the predominant epidemic pathogens were EV71, while in 2013 and 2015, the predominant epidemic pathogens turn to be CA16 and non-EV71, non-CA16 EV respectively. What’s more, collecting anal swab and pharyngeal swab virus at the same time for nucleic acid detection is of great significance to improve the HFMD laboratory diagnostic.

关键词： foot and mouth disease The Enterovirus Nucleic Acid Detection Popular Spectrum

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Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China:a hospital-based study

Seroprevalence of Toxoplasma gondii infection among patients...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Shuai Wang Chunwei Lan Luwen Zhang Haizhu Zhang Zhijun Yao Dong Wang Jingbo Ma Jiarong Deng Shiguo Liu Department of Human Parasitology School of Basic Medical Sciences Xinxiang Medical University First People's Hospital of Pingdingshan

The prevalence of infection with Toxoplasma gondii(T. gondii) in humans has been increasing in China due to the growing number of cats in the country. Hand, foot and mouth disease(HFMD) is a serious public health issue in China and still one of the leading causes of child mortality. However, little is known about the epidemiology of T. gondii infection among HFMD patients. A case-control study of 281 HFMD patients from the First People’s Hospital of Pingdingshan in Pingdingshan city, Henan province, central China, and 222 controls from Pingdingshan city was conducted. Anti-T. gondii antibodies were serologically detected using the enzyme-linked immunosorbent assay. We found that the overall anti-T. gondii immunoglobulin G(Ig G) antibody prevalence among HFMD patients was 12.46%, which was significantly higher than that in clinically healthy children(1.80%). The highest T. gondii seroprevalence was detected in critical cases(22.58%), followed by severe cases(11.50%), and the lowest was detected in mild cases(8.33%). The present study is the first survey of T. gondii seroprevalence among HFMD patients in China;12.46% were defined as seropositive. It is imperative that improved integrated measures are taken to prevent and control T. gondii infection among HFMD patients.

关键词： Toxoplasma gondii hand foot and mouth disease seroprevalence enzyme-linked immunosorbent assay China

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Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China: a hospital-based study

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Infectious diseases of Poverty 2015年第1期4卷 460-464页

作者： Shuai Wang Chunwei Lan Luwen Zhang Haizhu Zhang Zhijun Yao Dong Wang Jingbo Ma Jiarong Deng Shiguo Liu Department of Human Parasitology Xinxiang Medical UniversityXinxiangHenan 453003PR China First People’s Hospital of Pingdingshan PingdingshanHenan 467000PR China

Background:The prevalence of infection with Toxoplasma gondii(***)in humans has been increasing in China due to the growing number of cats in the ***,foot and mouth disease(HFMD)is a serious public health issue in China and still one of the leading causes of child ***,little is known about the epidemiology of *** infection among HFMD ***:A case–control study of 281 HFMD patients from the First People’s Hospital of Pingdingshan in Pingdingshan city,Henan province,central China,and 222 controls from Pingdingshan city was *** antibodies were serologically detected using the enzyme-linked immunosorbent ***:We found that the overall *** immunoglobulin G(IgG)antibody prevalence among HFMD patients was 12.46%,which was significantly higher than that in clinically healthy children(1.80%).The highest *** seroprevalence was detected in critical cases(22.58%),followed by severe cases(11.50%),and the lowest was detected in mild cases(8.33%).Conclusion:The present study is the first survey of *** seroprevalence among HFMD patients in China;12.46%were defined as *** is imperative that improved integrated measures are taken to prevent and control *** infection among HFMD patients.

关键词： Toxoplasma gondii Hand foot and mouth disease Seroprevalence Enzyme-linked immunosorbent assay China

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Clinical significance of inflammatory cytokine and chemokine expression in hand foot and mouth disease

Clinical significance of inflammatory cytokine and chemokine...

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浙江省免疫学会第十次学术大会

作者： Ping Shao Xiaoxin Wu Hongbo Li Zhigang Wu Zongxin Yang Hangping Yao Department of Infectious diseases First Affiliated HospitalZhejiang University School of Medicine State Key Laboratory for Diagnosis and Treatment of Infectious diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases First Affiliated HospitalZhejiang University School of Medicine Hangzhou Sixth People's Hospital

Purpose:To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand,foot and mouth disease(HFMD).Methods:This study involved 28 mild HFMD patients,44 severe HFMD patients and26 healthy *** blood was tested for cytokines(IL-4,IL-12,IL-18,TNF-α,IFN-γ) and chemokines(IL-8,RANTES,MCP-1,IP-10).Stool samples from the patients were tested for EV71 nucleic acid using reverse transcription polymerase chain ***:All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls(P disease progression and predict prognosis.

关键词： Hand foot and mouth disease enterovirus 71 inflammatory cytokines chemokines

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Epidemiology and etiological characteristics of hand,foot and mouth disease in Huizhou City between 2008 and 2011

Epidemiology and etiological characteristics of hand,foot an...

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作者： Fang Qiaoyun Ju Xiongfei Liang lihuan 许岸高 Center for disease Control and Prevention of Huizhou Huizhou Municipal Central Hospital

To study epidemiological features and etiological characteristics of hand,foot and mouth disease(HFMD),42,012 cases were investigated from April 2008 to December 2011 in Huizhou,*** average incidence rate was 21.16 per 10,*** highest peak of HFMD incidence was detected between April and July each year,accounting for 55.93%of all reported cases;another peak occurred in October through December,accounting for 24.17%of the *** the reported cases,89.75%were in children less than 4 years old,and there was a slight predominance of HFMD in boys and children living in rural and suburban *** major pathogens causing HFMD were enterovirus 71(EV71) and coxsackievirus AI6(CA16).C4 a was the most prominent EV71 subgenotype circulating in *** founding provides insight for developing public-health interventions for the control and prevention of HFMD,especially for reducing the risk of HFMD in high-risk individuals by taking precautions against enterovirus infections.

关键词： Hand foot and mouth disease Enterovirus Epidemiologic features Human enterovirus 71 Phylogenetic analysis

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Detection of human Enterovirus 71 reverse transcription loop-mediated isothermal amplification(RT-LAMP)

Detection of human Enterovirus 71 reverse transcription loop...

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2012深圳市预防医学会学术研讨会

作者： H.Yaqing Z.Wenping Y.Zhiyi W.Xionghu Y.Shouyi Y.Hong D.Yingchun H.Guifang Department of Epidemiology Southern Medical University Department of Microbiology Shenzhen Centerfor Disease Control and Prevention Department of Health Statistics Center for Medical Information of Shenzhen City

Aims:In this study,a one-step,single-tube reverse transcription loop-mediated isothermal amplification(RT-LAMP) assay was developed and validated for the detection of human Enterovirus 71(EV71),the major aetiological agent of hand,foot and mouth disease(HFMD). Methods and Results:Reverse transcription loop-mediated isothermal amplification assay was optimized to amplify VP1 gene in the presence of a specific primer set and Bst DNA polymerase at an isothermal temperature of 63℃for 1 *** products were evaluated by visual inspection and agarose gel *** detection limit of RT-LAMP assay was 105) 100 TCID50 or 160 copies in samples after RNA extraction,which was 10-fold higher in sensitivity than traditional reverse transcription polymerase chain reaction (RT-PCR).The specific positive amplification was only observed in EV71 strains,while no amplification was detected in other tested *** with a specific Escherichia coli restriction enzymes V(EcoR V) demonstrated that the amplified product was unique.A good correlation between RT-LAMP and real-time RT-PCR was observed on the basis of the analysis of 33 clinical samples. Conclusions:Reverse transcription loop-mediated isothermal amplification is a novel,alternative microbiological approach for rapid,sensitive and specific detection of EV71 in HFMD. Significance and lmpact of the Study:Reverse transcription loop-mediated isothermal amplification assay is suitable for the diagnosis of EV71 infection as a routine diagnostic tool for HFMD because of fewer requirements of experimental conditions such as private clinics,field applications as well as an epidemiological survey in epidemic ***-LAMP can also be used as an alternative method for EV71 detection.

关键词： hand foot and mouth disease human Enterovirus 71 reverse transcription loopmediated isothermal amplification

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Sero-prevalence, Risk Factor and Community Perception of foot and Mouse disease in Cattle under Extensive Management in Southern Tigray, Ethiopia

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Journal of Zoological Research 2020年第1期2卷 1-7页

作者： Angesom Taye Berihun Afera Nigus Abebe Ethiopian Institute of Agricultural Research(EIAR) Mekhoni Agricultural Research CenterMekhoniTigrayEthiopia Mekelle University MekelleTigrayEthiopia

To determine the sero-prevalence of foot and mouth disease in southern zone of Tigray,North Ethiopia,a cross-sectional examination of 340 sera samples were conducted from November 2015 up to May *** addition,a structured questionnaire survey was done to know the perception and knowledge of the local community about the disease and 120 informants were *** overall sero-prevalence was 20.9%and there was no statistical significant difference(P>0.05)in prevalence of foot and mouth disease between sexes,agro-ecology,breed and vaccination ***,a statistical significant difference(Pdisease consistent with the major clinical signs mentioned in *** study revealed that the virus is circulating in the area and requires further identification of the ***,implementing control of foot and mouth disease with integrated approaches has paramount importance.

关键词： Cattle foot and mouth disease Sero-prevalence Tigray

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