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flexibility analysis for continuous ibuprofen manufacturing processes

Chinese Journal of Chemical Engineering 2022年第11期51卷 115-125页

作者： Wenhui Yang Haoyu Yin Zhihong Yuan Bingzhen Chen State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Material Science and Engineering Tsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Continuous ibuprofen(a widespread used analgesic drug)manufacturing is full of superiorities and is a fertile field both in industry and academia since it can not only effectively treat rheumatic and other chronic and painful diseases,but also shows great potential in dental *** one of central elements of operability analysis,flexibility analysis is in charge of the quantitative assessment of the capability to guarantee the feasible operation in face of variations on uncertain *** this paper,we focus on the flexibility index calculation for the continuous ibuprofen manufacturing *** update existing state-of-the-art formulations,which traditionally lead to the max-max-max optimization problem,to approach the calculation of the flexibility index with a favorable *** regarding the size of the mathematical model and the computational CPU time of the modified method are examined by four *** addition to identifying the flexibility index without any consideration of control variables,we also investigate the effects of different combinations of control variables on the flexibility property to reveal the benefits from taking recourse actions into *** from systematic investigations are expected to provide a solid basis for the further control system design and optimal operation of continuous ibuprofen manufacturing.

关键词： Continuous manufacturing Pharmaceuticals Mathematical modeling flexibility analysis Mixed integer programing Optimization

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flexibility analysis and design of heat exchanger network for syngas-to-methanol process

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International Journal of Coal Science & Technology 2021年第6期8卷 1468-1478页

作者： Jinchang Liu Pingping Zhang Qiang Xie Dingcheng Liang Lei Bai School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)D11 Xueyuan RoadHaidian DistrictBeijing 100083China Department of Chemical and Biomedical Engineering West Virginia University395 Evansdale DrivePO Box 6102MorgantownWV 26506-6102USA

The heat exchanger network(HEN)in a syngas-to-methanol process was designed and optimized based on pinch technology under stable operating conditions to balance the energy consumption and economic *** actual industrial processes,fluctuations in production inevitably affect the stable operation of HENs.A flexibility analysis of the HEN was carried out to minimize such disturbances using the downstream paths *** results show that two-third of the downstream paths cannot meet flexibility requirements,indicating that the HEN does not have enough flexibility to accommodate the disturbances in actual production.A flexible HEN was then designed with the method of dividing and subsequent merging of streams,which led to 13.89%and 20.82%reductions in energy consumption and total cost,*** to the sufficient area margin and additional alternative heat exchangers,the flexible HEN was able to resist interference and maintain production stability and safety,with the total cost increasing by just 4.08%.

关键词： Heat exchanger network Syngas-to-methanol Pinch technology flexibility analysis Design Optimization

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An Extended Algorithm of flexibility analysis in Chemical Engineering Processes

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Chinese Journal of Chemical Engineering 2001年第1期9卷 51-57页

作者：徐强陈丙珍何小荣清华大学北京 100084

An extended algorithm of flexibility analysis with a local adjusting method for flexibility region of chemical processes, which is based on the active constraint strategy, is proposed, which fully exploits the flexibility region of the process system operation. The hyperrectangular flexibility region determined by the extended algorithm is larger than that calculated by the previous algorithms. The limitation of the proposed algorithm due to imperfect convexity and its corresponding verification measure are also discussed. Both numerical and actual chemical process examples are presented to demonstrate the effectiveness of the new algorithm.

关键词： flexibility analysis extended algorithm active constraint strategy

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A Modified Model for flexibility analysis in Chemical Engineering Processes

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Chinese Journal of Chemical Engineering 2004年第5期12卷 673-676页

作者：张蕾何小荣徐强 Department of Chemical Engineering Tsinghua University Beijing 100084 China

This paper discussed an extended model for flexibility analysis of chemical process. Under uncertainty, probability density function is used to describe uncertain parameters instead of hyper-rectangle, and chanceconstrained programming is a feasible way to deal with the violation of constraints. Because the feasible region of control variables would change along with uncertain parameters, its smallest acceptable size threshold is presented to ensure the controllability condition. By synthesizing the considerations mentioned above, a modified model can describe the flexibility analysis problem more exactly. Then a hybrid algorithm, which integrates stochastic simulation and genetic algorithm, is applied to solve this model and maximize the flexibility region. Both numerical and chemical process examples are presented to demonstrate the effectiveness of the method.

关键词： flexibility analysis chance-constrained programming stochastic simulation genetic algorithm

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