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Recent progress in silk fibroin-based flexible electronics

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Microsystems & Nanoengineering 2021年第3期7卷 1-25页

作者： Dan-Liang Wen De-Heng Sun Peng Huang Wen Huang Meng Su Ya Wang Meng-Di Han Beomjoon Kim Juergen Brugger Hai-Xia Zhang Xiao-Sheng Zhang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China CIRMM Institute of Industrial ScienceThe University of TokyoTokyo 153-8505Japan Microsystems Laboratory Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland Institute of Microelectronics Peking University100087 BeijingChina

With the rapid development of the Internet of Things(loT)and the emergence of 5G,traditional silicon-based electronics no Ion ger fully meet market dema nds such as nonplanar application scenarios due to mechanical *** provides unprecedented opportunities for flexible electronics that bypass the physical rigidity through the introduction of flexible *** recent decades,biological materials with outstanding biocompatibility and biodegradability,which are considered some of the most promising candidates for next-generation flexible electronics,have received increasing attention,e.g.,silk fibroin,cellulose,pectin,chitosan,and *** them,silk fibroin presents greater superiorities in biocompatibility and biodegradability,and moreover,it also possesses a variety of attractive properties,such as adjustable water solubility,remarkable optical transmittance,high mechanical robustness,light weight,and ease of processing,which are partially or even completely lacking in other biological ***,silk fibroin has been widely used as fundamental components for the construction of biocompatible flexible electronics,particularly for wearable and implantable ***,in recent years,more attention has been paid to the investigation of the functional characteristics of silk fibroin;such as the dielectric properties,piezoelectric properties,strong ability to lose electrons,and sensitivity to environmental ***,this paper not only reviews the preparation technologies for various forms of silk fibroin and the recent progress in the use of silk fibroin as a fundamental material but also focuses on the recent advaneed works in which silk fibroin serves as functional *** on ally,the challenges and future development of silk fibroin-based flexible electronics are summarized.

关键词： fibroin silk attractive

Random lasing detection of structural transformation and compositions in silk fibroin scaffolds

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Nano Research 2019年第2期12卷 289-297页

作者： SungYeun Yang Soocheol Kim Hyeln Shin Seung Ho Choi Young L. Kim Chulmin Joo WonHyoung Ryu Department of Mechanical Engineering Yonsei University Yonsei-ro 50 Seodaemun-gu Seoul 03722 Republic of Korea Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 47907 USA Present address: Center of Bio Microsystems Korea Institute of Science and Technology (KIST) Hwarang-ro Seongbuk-gu Seoul 02792 Republic of Korea School of Electrical Engineering University of Ulsan Daehak-ro Nam-gu Ulsan 44610 Republic of Korea

In tissue engineering, microstructure and material composition of tissue scaffolds have major influences on the proliferation and differentiation of cells in the scaffolds. However, once tissue scaffolds implanted, it is extremely difficult to monitor the change of their microstructure and compositions during tissue regeneration. Here, we report how random lasing can be utilized to non-invasively monitor the structure and composition of scaffolds. We hypothesize that morphological and compositional change of silk fibroin (SF) scaffolds can be conveniently detected based on random lasing responses. Engineered SF scaffolds with hydroxyapatite (HAP) nanoparticles and controlled pore alignment were fabricated, and their random lasing responses were analyzed depending on the concentration of HAP nanoparticles and the degree of,:internal pore alignment. We also examined the real-time random lasing responses of porous SF scaffolds by applying a compressive force to' the scaffolds. Introduction of HAP nanoparticles lowered the lasing thresholds and narrowed the random lasing (RL) width dramatically, which :is likely due to the increase in heterogeneity in both refractive index and physical arrangement within the SF and HAP composites. The strong dependency of RL response on pore alignment was also measured and validated by numerical calculation with the finite element method (FEM).Finally, real-time monitoring of RL on compressed scaffolds demonstrated the possibility of using RL as a monitoring tool for structural change of SF scaffolds in vivo.

关键词： random lasing silk fibroin porous scaffolds aligned pore structure electrospinning hydroxyapatite

Progress in modification of silk fibroin fiber

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Science China(Technological Sciences) 2019年第6期62卷 919-930页

作者： LIU Li ZHANG Song HUANG JunYi School of Materials Science and Engineering Shanghai University Shanghai 200444 China Jiangsu Aiteli Textile Technology Co. Ltd. Qidong 226200 China School of Life Sciences Shanghai University Shanghai 200444 China

Silk fibroin fiber is a natural protein fiber. It is moisturizing, breathable, soft and skin-friendly. However, unmodified silk fibroin fiber is easy to be oxidized and faded. In this paper, the recent progress in modification of silk fibroin fiber is introduced,including the composite modification, feeding modification, genetic engineering modification, spinning technology and regulating the physiological environment modification. Simultaneously, the future development trend for the modification of silk fibroin fiber is also prospected.

关键词： silk fibroin fiber nano particles modification of silk fibroin fiber genetic engineering electrospinning

Expression of the Japanese oak silkworm Antheraea yamamai fibroin gene in the domesticated silkworm Bombyx mori

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Insect Science 2009年第6期16卷 465-473页

作者： Isao Kobayashi Katsura Kojima Hideki Sezutsu Keiro Uchino Toshiki Tamura Transgenic Silkworm Research Center Silk Materials Research Unit National Institute of Agrobiological Sciences Ibaraki Japan

To understand the evolutionary conservation ofthe gene expression mechanism and secretion machinery between Antheraea and Bombyx fibroins, we introduced the genomic A. yamamai fibroin gene into the domesticated silkworm, B. mori. The spliced A. yamamai fibroin mRNA appeared only in the posterior region of the silk gland of the transgenic silkworm, suggesting that the functions of the fibroin promoter region and the splicing machinery are conserved between these two species. The A. yamarnai fibroin protein was detected in the lumen of the silk gland of the transgenic silkworm, albeit at lower levels compared with the B. mori-type fibroin. We found a strong degeneration of the posterior region of the silk gland of the transgenic silkworm. As a result, the cocoon shell weight was much lower in the transgenic silkworm than in the non-transgenic line. These results indicate that the promoter function and splicing machinery are well conserved between A. yamamai and B. mori but that the secretion mechanism of fibroin is diversified between the two.

关键词： Antheraea yamamai Bombyx mori evolution fibroin silk transgenic

Biocompatible, small-sized and well-dispersed gold nanoparticles regulated by silk fibroin fiber from Bombyx mori cocoons

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Frontiers of Materials Science 2019年第2期13卷 126-132页

作者： Chengzhi YANG Shikun CHEN Huilan SU Haoyue ZHANG Jianfei TANG Cuiping GUO Fang SONG Wang ZHANG Jiajun GU Qinglei LIU State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiaotong University Shanghai 200240 China

Biocompatible, small-sized but well-dispersed gold nanoparticles (Au NPs) remain a major challenge for their synthesis. Here a convenient solution impregnation technique is developed to prepare such Au NPs under the regulation of degummed silk fibroin fibers (SFFs) extracted from Bombyx mori cocoons. SFFs play multiple roles in the formation of Au NPs such as reactive substrate to capture AuCl4^- ions by the chelation of -C = 0, reducing agent for Au(0) by the reduction of -OH , and modifiers to render biocompatible Au NPs by some functional groups and biomolecules. The as-prepared Au NPs with a size of 7-10 nm are embedded in the solid SFF substrate, and can disperse well in the liquid system by the disintegration of SFFs into silk fibroin (SF) in a certain CaCl2 solution. The biocompatible Au NPs exhibit uniform small size and distribute stably in both solid and solution states, which have distinctive properties and functional advantages, and bring great convenience to their storage and transportation.

关键词： Au NPs biocompatibility small size dispersivity silk fibroin fiber

Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury

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Neural Regeneration Research 2020年第5期15卷 959-968页

作者： Ji-Peng Jiang Xiao-Yin Liu Fei Zhao Xiang Zhu Xiao-Yin Li Xue-Gang Niu Zi-Tong Yao Chen Dai Hui-You Xu Ke Ma Xu-Yi Chen Sai Zhang Department of Thoracic Surgery General Hospital of People’s Liberation Army (PLA)BeijingChina Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCenter for Neurology and Neurosurgery of Chinese People’s Armed Police Force (PAP) Medical CenterTianjinChina Tianjin Medical University TianjinChina Department of Neurology Luoyang First Hospital of Traditional Chinese MedicineLuoyangHenan ProvinceChina Department of Neurosurgery Fourth Central Hospital of TianjinTianjinChina

Many studies have shown that bio-scaffolds have important value for promoting axonal regeneration of injured spinal ***,cell transplantation and bio-scaffold implantation are considered to be effective methods for neural *** study was designed to fabricate a type of three-dimensional collagen/silk fibroin scaffold (3D-CF) with cavities that simulate the anatomy of normal spinal *** scaffold allows cell growth in vitro and in *** observe the effects of combined transplantation of neural stem cells (NSCs) and 3D-CF on the repair of spinal cord *** Sprague-Dawley rats were divided into four groups: sham (only laminectomy was performed),spinal cord injury (transection injury of T10 spinal cord without any transplantation),3D-CF (3D scaffold was transplanted into the local injured cavity),and 3D-CF + NSCs (3D scaffold co-cultured with NSCs was transplanted into the local injured ***,imaging,hematoxylin-eosin staining,argentaffin staining,immunofluorescence staining,and western blot assay were *** from the sham group,neurological scores were significantly higher in the 3D-CF + NSCs group compared with other ***,latency of the 3D-CF + NSCs group was significantly reduced,while the amplitude was significantly increased in motor evoked potential *** results of magnetic resonance imaging and diffusion tensor imaging showed that both spinal cord continuity and the filling of injury cavity were the best in the 3D-CF + NSCs ***,regenerative axons were abundant and glial scarring was reduced in the 3D-CF + NSCs group compared with other *** results confirm that implantation of 3D-CF combined with NSCs can promote the repair of injured spinal *** study was approved by the Institutional Animal Care and Use Committee of People’s Armed Police Force Medical Center in 2017 (approval No.2017-0007.2).

关键词： 3D bioprinting collagen diffusion tensor imaging functional recovery magnetic resonance imaging nerve regeneration neural regeneration neural stem cell scaffold silk fibroin spinal cord injury

Preparation and characterization of noble metal nanocolloids by silk fibroin in situ reduction

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Science China Chemistry 2003年第4期46卷 330-338页

作者：陈文兴吴雯陈海相沈之荃 College of Materials and Textiles Zhejiang Institute of Science and Technology Hangzhou 310033 China Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Noble metal nanocolloids are prepared from their precursors by in situ reduction of a silk fibroin solution at room temperature without any reducing agent. The mechanism, the effects of pH and the molar ratio of the reactants on the reduction reaction are studied by UV-Vis spectros-copy. The structure of the colloids is characterized by FT-IR, TEM and AFM. According to the TEM images, the gold-silk fibroin colloid is a nanostructured bioconjugate with novel core-shell, while the silver-silk fibroin colloid tends to be congregated as clusters having more than ten nanoparti-cles of silver-silk fibroin. The gold colloid is highly dispersed and stable while the silver colloid is less dispersed and stable than the gold colloid.

关键词： silk fibroin , in situ reduction, gold colloid, silver colloid.

Effect of process parameters on additive-free electrospinning of regenerated silk fibroin nonwovens

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Bioactive Materials 2020年第2期5卷 241-252页

作者： Alexander Kopp Ralf Smeets Martin Gosau Nadja Kröger Sandra Fuest Marius Köpf Magnus Kruse Judith Krieger Rico Rutkowski Anders Henningsen Simon Burg Fibrothelium GmbH AachenGermany Department of Oral and Maxillofacial Surgery University Medical Center Hamburg-EppendorfHamburgGermany Department of Oral and Maxillofacial Surgery Division of Regenerative Orofacial MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany Institut Fuer Textiltechnik of RWTH Aachen University AachenGermany Department of Oral and Maxillofacial Surgery German Armed Forces HospitalHamburgGermany Department of Plastic Reconstructive and Aesthetic SurgeryUniversity Hospital of CologneCologneGermany

Silk fibroin is a biomaterial with multiple beneficial properties for use in regenerative medicine and tissue *** dissolving and processing the reconstituted silk fibroin solution by electrospinning,the arrangement and size of fibers can be manifold varied and according fiber diameters reduced to the nanometer *** nonwovens show high porosity as well as potential ***,electrospinning of most biomaterials demands for the application of additives,which enable stable electrospinning by adjusting viscosity,and are intended to evaporate during processing or to be washed out ***,the use of such additives increases costs and has to be taken into account in terms of biological risks when used for biomedical *** this study,we explored the possibilities of additive-free electrospinning of pure fibroin nonwovens and tried to optimize process parameters to enable stable *** used natural silk derived from the mulberry silkworm Bombyx *** degumming,the silk fibroin was dissolved and the viscosity of the spinning solution was controlled by partial evaporation of the initial solving *** way,we were able to completely avoid the use of additives and manufacture nonwovens,which potentially offer higher biocompatibility and reduced *** and relative humidity during electrospinning were systematically varied(25–35°C,25–30%RH).In a second step,the nonwovens optionally underwent methanol treatment to initiate beta-sheet formation in order to increase structural integrity and *** surface analysis on the different nonwovens was performed using scanning electron microscopy and supplemented by additional mechanical *** was evaluated using BrdU-assay,XTT-assay,LDH-assay and live-dead *** findings were,that an increase of temperature and relative humidity led to unequal fiber diameters and defective *** to penetration decr

关键词： fibroin Additive-free electrospinning Nanofiber Silk Scaffolds

Gelation behavior of Antheraea pernyi silk fibroin

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Science China Chemistry 2010年第3期53卷 535-541页

作者： YAN ShuQin,ZHAO ChunXia,WU XiuFang,ZHANG Qiang & LI MingZhong National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering Soochow University Suzhou China

The sol-gel transition behavior of Antherae pernyi silk fibroin(Ap-SF) has not been systematically *** this work,the influence of environmental temperature,pH,the concentration of Ap-SF,K+ and Ca2+ on the gelation time,and the structural changes of Ap-SF in sol-gel transformation were *** results indicated that the gelation time of the Ap-SF aqueous solution decreased with the increase of the Ap-SF concentration and environmental *** sol-gel transformation of Ap-SF was much more rapid than that of Bombyx mori silk fibroin under the same *** Ap-SF was sensitive to changes in the concentration of Ca2+ and K+.Upon gelation,the random coil structure of the Ap-SF was significantly transformed into the β-sheet structure.

关键词： Antheraea pernyi silk fibroin gelation sol-gel transition