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Radio Active Tracingsin Brains of fetal mice Conceilled by Dan mice after with ^(125)I Labelled Toxoplasm a Gondii

The Journal of Biomedical Research 1999年第2期23卷 65-69页

作者： Wang Haiqi(王海琦) Mei Weining(梅尉林) Shao Yanan(邵亚男) Zhang Jianning(张建宁) [WT5,5”BZ]Department of Obstertrics and Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029, P. R. China

I labelled T. gondii parasites were injected via tail vein into 14 day pregnant mouse( Kunming strain). Radioactive tracings of fetal train and pathologic changes were studiet. The results revealed that infection rates in the pregnant mice and in their fetal heads were 30.60% and 71.2% respectively. The ratio of the radioactivity between the fetal heads and the fetal trunks was 1.32-5.95 , being directly proportional to the durations of infection. Autoradiographs of light and electron microscopy indicated that the parasites appeared in the neurogliocytes of the fetal mice as early as 4 8 h post infection, and might be seen in the nucleus 48h after infection with degeneration and rupture of the cells. Numbers of the cranial nerve cells was distinctively reduced at 72h post infection. This study thus provided the experimental pathology evidence for the development of fetal neural malformation and cerebral lesions from T. gondil infected dam mouse.

关键词： I labelled T. gondii fetal mice redioactive tracing autoradiography

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Induction of adaptive response in utero by ionizing radiation:A radiation quality dependent phenomenon

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BIOCELL 2022年第10期46卷 2315-2325页

作者： BING WANG KAORU TANAKA KOUICHI MARUYAMA YASUHARA NINOMIYA TAKANORI KATSUBE MITSURU NENOI National Institutes for Quantum Science and Technology Chiba263-8555Japan

Investigation on possible induction of adaptive response(AR)by high-liner energy transfer(LET)particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in *** study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal *** body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray *** monoenergetic beams of carbon,silicon and iron with the LET values of about 15,55,and 200 KeV/μm,respectively,were *** suppression by the priming radiation of the detrimental effects(fetal death,malformation,or low body weight)was used as the endpoints for judgment of a successful AR induction on gestation day *** of AR was not *** the other hand,the priming dose of high-LET particle radiation,in some cases,even increased the detrimental effects induced by the challenge dose from low-LET X-ray *** existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated,the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.

关键词： Heavy particle radiation Adaptive response High liner energy transfer Teratogenesis fetal mice

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