Induction of adaptive response in utero by ionizing radiation:A radiation quality dependent phenomenon

作     者：BING WANG KAORU TANAKA KOUICHI MARUYAMA YASUHARA NINOMIYA TAKANORI KATSUBE MITSURU NENOI 

作者机构：National Institutes for Quantum Science and TechnologyChiba263-8555Japan 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2022年第46卷第10期

页      面：2315-2325页

核心收录：

学科分类：07[理学] 070202[理学-粒子物理与原子核物理] 0702[理学-物理学] 

基　　金：This research was financially supported in part by the Grant-in-Aid for Scientific Research(C)(JSPS KAKENHI 21510060 and JSPS KAKENHI 25340041) Research Project Grants with Heavy Ions at HIMAC,QST,Japan(19B-258 and 22B-258) 

主　　题：Heavy particle radiation Adaptive response High liner energy transfer Teratogenesis Fetal mice 

摘      要：Investigation on possible induction of adaptive response(AR)by high-liner energy transfer(LET)particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in *** study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal *** body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray *** monoenergetic beams of carbon,silicon and iron with the LET values of about 15,55,and 200 KeV/μm,respectively,were *** suppression by the priming radiation of the detrimental effects(fetal death,malformation,or low body weight)was used as the endpoints for judgment of a successful AR induction on gestation day *** of AR was not *** the other hand,the priming dose of high-LET particle radiation,in some cases,even increased the detrimental effects induced by the challenge dose from low-LET X-ray *** existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated,the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.