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Associations between cancer Family history and esophageal cancer and precancerous lesions in high-risk areas of China

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Chinese Medical Journal 2022年第7期135卷 813-819页

作者： Jiachen Zhou Kexin Sun Shaoming Wang Ru Chen Minjuan Li Jianhua Gu Zhiyuan Fan Guihua Zhuang Wenqiang Wei Department of Epidemiology and Biostatistics School of Public HealthXl’an Jiaotong University Health Science CenterXi’anShaanxi 710061China National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:family clustering of esophageal cancer(EC)has been found in high-risk areas of China.However,the relationships between cancer Family history and esophageal cancer and precancerous lesions(ECPL)have not been comprehensively reported in recent years.This study aimed to provide evidence for identification of high-risk populations.Methods:This study was conducted in five high-risk areas in China from 2017 to 2019,based on the National Cohort of Esophageal Cancer.The permanent residents aged 40 to 69 years were examined by endoscopy,and pathological examination was performed for suspicious lesions.Information on demographic characteristics,environmental factors,and cancer Family history was collected.Unconditional logistic regression was applied to evaluate odds ratios between Family history related factors and ECPL.Results:Among 33,008 participants,6143(18.61%)reported positive Family history of EC.The proportion of positive Family history varied significantly among high-risk areas.After adjusting for risk factors,participants with a Family history of positive cancer,gastric and esophageal cancer or EC had 1.49-fold(95%confidence interval[CI]:1.36-1.62),1.52-fold(95%CI:1.38-1.67),or 1.66-fold(95%CI:1.50-1.84)higher risks of ECPL,respectively.Participants with single or multiple first-degree relatives(FDR)of positive EC history had 1.65-fold(95%CI:1.47-1.84)or 1.93-fold(95%CI:1.46-2.54)higher risks of ECPL.Participants with FDRs who developed EC before 35,45,and 50 years of age had 4.05-fold(95%CI:1.30-12.65),2.11-fold(95%CI:1.37-3.25),and 1.91-fold(95%CI:1.44-2.54)higher risks of ECPL,respectively.Conclusions:Participants with positive Family history of EC had significantly higher risk of ECPL.This risk increased with the number of EC positive FDRs and EC Family history of early onset.Distinctive genetic risk factors of the population in high-risk areas of China require further investigation.Trial registration:ChiCTR-EOC-17010553.

关键词： Esophageal cancer Family history High-risk area Cross-sectional study

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Chronic complications risk among type 2 diabetes patients with a Family history of diabetes

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Chronic Diseases and Translational Medicine 2023年第4期9卷 336-340页

作者： Dicky L.Tahapary Syahidatul Wafa Christian Tricaesario Felix F.Widjaja Jimmy Tandradynata Rudy Kurniawan William Djauhari Afif H.Maruf Muhammad Yamin Sidartawan Soegondo Diabetes Connection&Care Eka Hospital BSDSouth TangerangIndonesia Division of Endocrinology Metabolismand DiabetesDepartment of Internal MedicineCipto Mangunkusumo National Referral HospitalFaculty of MedicineUniversitas IndonesiaJakartaIndonesia Metabolic Disorder Cardiovascularand Aging Research CentreThe Indonesian Medical Education and Research InstituteFaculty of Medicine Universitas IndonesiaJakartaIndonesia Diabetes Connection&Care Eka Hospital CibuburBogorIndonesia MYcardia Arrhythmia and Cardiovascular Center Eka Hospital BSDSouth TangerangIndonesia Division of Cardiology Department of Internal MedicineCipto Mangunkusumo National Referral HospitalFaculty of MedicineUniversitas IndonesiaJakartaIndonesia

Family history of diabetes(FH+)has been associated with early metabolic alteration including insulin resistance,lipid metabolism,and ectopic fat accumulation even in healthy individuals.1-3 Furthermore,normoglycemic firstdegree relatives of type 2 diabetes mellitus(T2DM)have been documented having increased carotid intimamedia thickness_and pro-inflammatory cytokines.4.s Taken together,individuals with FH+,who were otherwise healthy,have shown to possess susceptibility for diabetes mellitus(DM)chronic complication.Hence,this study aimed to investigate whether FH+increased the risk of chronic complications in patients with overt T2DM.

关键词： complications Family history type 2 diabetes mellitus

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Family history of esophageal cancer modifies the association of serum lipids and malignant esophageal lesions:a nested case-control study from the"Endoscopic Screening for Esophageal Cancer in China"trial

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Chinese Medical Journal 2021年第9期134卷 1079-1086页

作者： Min-Min Wang Chuan-Hai Guo Feng-Lei Li Rui-Ping Xu Zhen Liu Ya-Qi Pan Fang-Fang Liu Ying Liu Hong Cai Meng-Fei Liu Zhong-Hu He Yang Ke Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of GeneticsPeking University Cancer Hospital and InstituteBeijing 100142China Hua County People's Hospital AnyangHenan 456400China Anyang Cancer Hospital AnyangHenan 455000China

Background:The association of lipids and cancer has varied greatly among different cancer types,lipid components and study populations.This study is aimed to investigate the association of serum lipids and the risk of malignant lesions in esophageal squamous epithelium.Methods:In the"Endoscopic Screening for Esophageal Cancer in China"(ESECC)trial,serum samples were collected and tested for total cholesterol(TC),triglycerides,low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol at the time of subject enrollment.Cases were defined as malignant esophageal lesions identified by baseline endoscopic examination or by follow-up to May 31,2018.Controls were randomly selected using incidence density sampling in the same cohort.Conditional logistic models were applied to identify the association of serum lipids and the risk of malignant esophageal lesions.Effect modification was evaluated by testing interaction terms of the factor under assessment and these serum lipid indicators.Results:No consistent association between serum lipid levels and esophageal malignant lesions were found in a pooled analysis of 211 cases and 2101 controls.For individuals with a Family history of esophageal cancer(EC),high TC,and LDL-C were associated with a significantly increased risk of having malignant lesions(odds ratio[OR]Highvs.Low TC=2.22,95%confidence interval[CI]:1.14-4.35;ORHighvs.Low LDL-C=1.93,95%CI:1.01-3.65).However,a negative association was observed in participants without an EC Family history(ORHighvs.Low TC=0.69,95%CI:0.48-0.98,Pinteraction=0.002;ORHighvs.Low LDL-C=0.50,95%CI:0.34-0.76,PinteractionFamily history.The stratified analysis would be crucial for population-based studies investigating the association of serum lipids and cancer.The mechanism by which a Family history of EC modifies this association warrants further investigation.

关键词： Effect modification Esophageal squamous cell carcinoma Family history Genetic susceptibility Lipids and lipoprotein

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A comparison of genetic risk score with Family history for estimating prostate cancer risk

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Asian Journal of Andrology 2016年第4期18卷 515-519页

作者： Brian T Helfand Division of Urology NorthShore University HealthSystem University of Chicago Pritzker School of Medicine 2650 Ridge Avenue Evanston IL 60201 USA.

Prostate cancer （PCa） testing is recommended by most authoritative groups for high-risk men including those with a Family history of the disease. However, Family history information is often limited by patient knowledge and clinician intake, and thus, many men are incorrectly assigned to different risk groups. Alternate methods to assess PCa risk are required. In this review, we discuss how genetic variants, referred to as PCa-risk single-nucleotide polymorphisms, can be used to calculate a genetic risk score （GRS）. GRS assigns a relatively unique value to all men based on the number of PCa-risk SNPs that an individual carries. This GRS value can provide a more precise estimate of a man＇s PCa risk. This is particularly relevant in situations when an individual is unaware of his Family history. In addition, GRS has utility and can provide a more precise estimate of risk even among men with a positive Family history. It can even distinguish risk among relatives with the same degree of family relationships. Taken together, this review serves to provide support for the clinical utility of GRS as an independent test to provide supplemental information to Family history. As such, GRS can serve as a platform to help guide-shared decision-making processes regarding the timing and frequency of PCa testing and biopsies.

关键词： Family history genetic risk score prostate cancer single-nucleotide polymorphisms

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The impact of Family history of hepatocellular carcinoma on its patients' survival

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 160-164页

作者： Wing Chiu Dai Sheung Tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Ronnie TP Poon Chung Mau Lo Department of Surgery The University of Hong Kong 102 Pokfulam Road Hong Kong China State Key Laboratory for Liver Research The University of Hong Kong 102 Pokfulam Road Hong Kong China

BACKGROUND:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the disease.The aim of this study is to evaluate the impact of such a history on HCC patients’ survival.METHODS:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively collected.The patients were quizzed on their various characteristics including family HCC history.RESULTS:Totally 475(10.48%) patients had a Family history of HCC.They presented the disease at a significantly earlier age(median 53 vs 59 years,PFamily history of HCC had better overall survival than those without such a history.We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients.However,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified.

关键词： hepatocellular carcinoma Family history resection survival risk factor

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Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 556-563页

作者： Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless Department of Medicine Division of Gastroenterology and HepatologyJohns Hopkins University Guangdong provincial Key Laboratory of Colorectal and Pelvic Floor Diseases the Sixth Affiliated Hospital of Sun Yat-sen University Department of Gastroenterology the Sixth Affiliated Hospital of Sun Yat-sen University Department of Medicine Med Star Health Internal Medicine Department of Health and Sport Sciences Federal University of Acre Department of Medicine Faculty of Medicine and Health SciencesAn-Najah National University Ravindra Nath Tagore Medical College St Vincent Hospital Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health

AIM To investigate the differences in Family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD Family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of Family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in Family history during the continuing rise in IBD may provide further insight into the etiology of CD.

关键词： Crohn’s disease Family history Disease outcome Inflammatory bowel disease Epidemiology genetics Environment Medication Surgery

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Changes of insulin resistance and plasma levels of Ang Ⅱ and NO in normal offspring with a Family history of es sential hypertension

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South China Journal of Cardiology 2012年第1期13卷 36-39,45页

作者：贾辉辉吴娜傅增泮 Qingdao University Medical College Department of Cardiology Qingdao Municipal Hospital Department of Cardiology Affiliated Hospital of Qingdao University Medical College

Backgound Essential hypertension （EH） is a polygenic inheritable disease,generally known as a combined result of genetic and environmental elements.It is possible that IR、AngiotensinⅡ（AngⅡ） and NO play important roles in the pathogenesis of EH.Methods Sixty normal subjects with a Family history of EH,aged 30 to 40 years old,were recruited and randomized into two groups：30 with one parent and 30 with both parents with EH,and 30 subjects without Family history of EH as controls.The plasma level of NO was determined by electrophotometer while the plasma level of fast insulin （FINS） and AngⅡ were determined by radioimmuno-assay,and insulin resistance index （IRI） was calculated.Results ① The plasma levels of FINS,AngⅡ,NO increased significantly in study groups compared with those in the control group（P 0.01）,while there were no differences in the levels of AngII,NO between the two study groups （P 0.05）.② The plasma level of AngII were positively correlated with that of NO（r=0.378,P 0.01）.Conclusions The higher levels of IR and plasma AngII and NO exist before the development of EH in normal offspring with a Family history of EH,and maybe they are initial agents in the pathogenesis of EH.It indicates that the people with IR and high levels of plasma AngⅡand NO with a Family history of EH are at higher risk to develop EH.

关键词： hypertension insulin resistance NO angiotensinⅡ Family history

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Multiple lentigines syndrome with positive Family history:a case report and review of the literature

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Clinical Research Communications 2023年第1期6卷 15-18页

作者： Jing Xu Yi Chen Ling Huang Chang-Wen Ni Si-Qi Yang Hu Ren Ru-Bin Yang Department of Dermatology The First Affiliated Hospital of Dali UniversityYunnan 671003China Department of Dermatology The Third Hospital of MianyangSichuan 621054China

Multiple lentigines syndrome is an autosomal dominant genetic disease,and its expressivity and penetrance are variable.It is also known as LEOPARD syndrome(LS).The genes known to be associated with LS include PTPN11,RAF1 and BRAF.The diagnosis of LS(OMIM 151100)is based on the observation of key features in the clinical background.LS caused by a germline PTPN11 mutation are characterized as multisystemic anomalies and variable marked phenotypes such as multiple lentigines and cafénoir spots,electrocardiographic conduction abnormalities,ocular hypertelorism/obstructive cardiomyopathy,pulmonary stenosis,abnormal genitalia,retardation of growth,and deafness.Phenotype overlap complicates clinical discrimination within RASopathies,making the diagnosis of LS more confusing and challenging.Besides,LS patients do not usually present with all these typical clinical features,increasing the possibility of underdiagnosis or misdiagnosis.Herein,we report a case of a 41-year-old male presenting with multiple dark pigmented macules all over the body,thoracic deformity and Family history.And we followed up the patients.

关键词： multiple lentigines syndrome LEOPARD syndrome Family history

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Prevalence of Family history of Cancer among Gastric Cancer Patients at Brazilian National Cancer Institute

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Health 2017年第1期9卷 25-37页

作者： Tamara Figueiredo Maria Teresa Santos Guedes Luis Paulo Souza e Souza Antonio Abílio Santa Rosa Antonio Carlos Accetta Maria Aparecida de Luca Nascimento Lais Santiago Deivite Danilo Ferreira Alcantara Department of Postgraduate in Adult Health Federal University of Minas GeraisBelo HorizonteBrazil Department of Radiotherapy Health Foundation Dilson de Quadros GodinhoMontes ClarosBrazil National Tumor/DNA Bank National Cancer Institute Rio de JaneiroBrazil Department of Postgraduate Course in Nursing and Biosciences Federal University of Rio de Janeiro StateRio de JaneiroBrazil Department of Postgraduation in Public Health Federal University of Minas GeraisBelo HorizonteBrazil Department of Medicine Federal University of Sao Joao del ReiSao Joao del ReiBrazil Research Department of the Bonsucesso General Hospital Ethics Committee National Cancer InstituteRio de JaneiroBrazil Department of Abdominal-Pelvic Surgery National Cancer InstituteRio de JaneiroBrazil Department of Chemotherapy National Cancer InstituteRio de JaneiroBrazil

Background: Gastric cancer is the third most incident malignancy and the fifth leading cause of death in the world. In Brazil, it is the fourth most common tumour in men and the fifth in women. Familial aggregation of this tumour is being studied and discussed by experts. Aim: Determine the frequency of Family history of cancer in patients with gastric cancer, suggesting familial aggregation or increased risk for hereditary cancer syndromes. Methods: This is a retrospective cross-sectional study carried out from January 2011 to March 2015 at the Department of Abdominal and Pelvic Surgery of the Brazilian National Cancer Institute (INCA). Data were collected from electronic medical records and analyzed using SPSS Statistics? version 20. Results: 873 patients with gastric adenocarcinoma were analyzed. A Family history of cancer was reported by 451 patients (51.6%), which reported cancer in 878 relatives, of which 110 (12.6%), reported having more than three relatives with any type of cancer. The most prevalent malignancies among these relatives were gastric cancer (21.3%) and breast cancer (9.5%). Conclusion: Most of the patients had cancer Family history, being gastric cancer the most common. The high percentage of cancer Family history confirms the importance of collecting this information, whose lack reflects professional negligence, as Family history study can serve as a low-cost tool, favoring prevention and early diagnosis, situations where morbidity and mortality are smaller, thus reducing health costs and assistance and preserving lives.

关键词： Stomach Neoplasms Family history Hereditary Aggregation Hospital Records Cross-Sectional Studies

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Novel subtype of obesity influencing the outcomes of sleeve gastrectomy:Familial aggregation of obesity

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World Journal of Gastroenterology 2024年第13期30卷 1887-1898页

作者： Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Department of General Surgery The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of Postgraduate Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina Department of General Surgery Shandong Provincial Qianfoshan HospitalCheeloo College of Medicine Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276005Shandong ProvinceChina

BACKGROUND Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy(SG)between patients with familial aggregation of obesity(FAO)and patients with sporadic obesity(SO)have not been elucidated.AIM To explore the impact of SG on weight loss and the alleviation of obesity-related comorbidities in individuals with FAO.METHODS A total of 193 patients with obesity who underwent SG were selected.Patients with FAO/SO were matched 1:1 by propensity score matching and were categorized into 4 groups based on the number of first-degree relatives with obesity(1 SO vs 1FAO,2SO vs 2FAO).The baseline characteristics,weight loss outcomes,prevalence of obesity-related comorbidities and incidence of major surgeryrelated complications were compared between groups.RESULTS We defined FAO as the presence of two or more first-degree relatives with obesity.Patients with FAO did not initially show significant differences in baseline data,short-term postoperative weight loss,or obesity-related comorbidities when compared to patients with SO preoperatively.However,distinctions between the two groups became evident at the two-year mark,with statistically significant differences in both percentage of total weight loss(P=0.006)and percentage of excess weight loss(P<0.001).The FAO group exhibited weaker remission of type 2 diabetes mellitus(T2DM)(P=0.031),hyperlipidemia(P=0.012),and non-alcoholic fatty liver disease(NAFLD)(P=0.003)as well as a lower incidence of acid reflux(P=0.038).CONCLUSION FAO patients is associated with decreased mid-to-long-term weight loss outcomes;the alleviation of T2DM,hyperlipidemia and NAFLD;and decreased incidence of acid reflux postoperatively.

关键词： Obesity Bariatric surgery Sleeve gastrectomy Family history Weight loss

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