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extraskeletal Chondroma in the Popliteal Region: A Case Report

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Chinese Medical Sciences Journal 2015年第4期30卷 270-272页

作者： Bing-yan Mao Department of Orthopaedic Surgery Shimen Hospital of Changsha Medical University

extraskeletal chondroma is a rare benigntumor that usually develops in the soft tissue,which commonly occurs in the limbs of adults andgenerally presents as painless masses without thesurrounding tissues involvement. The diagnosis mainlydepends on computed tomography, magnetic resonanceimaging （MRI） examination, and postoperative pathologicalexamination. This paper reports a case of extraskeletalchondroma in the popliteal region.

关键词： extraskeletal chondroma popliteal region

Perigastric extraskeletal Ewing's sarcoma: A case report

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World Journal of Gastroenterology 2009年第2期15卷 245-247页

作者： Radoje B Colovic Nikica M Grubor Marjan T Micev Slavko V Matic Henry Dushan Edward Atkinson Stojan M Latincic Institute for Digestive Diseases Clinical Center of Serbia Koste Todorovica 6 Belgrade 11000 Serbia Imperial College School of Medicine St Mary's Hospital Praed Street London W2 1NY United Kingdom

Ewing's sarcoma (ES) is a neoplasm of undifferentiated small round cells, which occurs in the bones and deep soft tissues of children and adolescents. We present a rare case of a 44-year-old woman with gastric ES presenting with epigastric pain and weight loss. Ultrasound and computed tomography scans indicated a solid/cystic mass in the pancreatic tail. At laparotomy, the tumor was found attached to the posterior surface of the stomach, completely free from the pancreas, with no lymphadenopathy or local metastases. The polynodal, partly pseudocystic, dark-red soft tumor was excised. Histopathology revealed an anaplastic small-round-cell tumor with strong membranous CD99 immunoexpression. Additionally, there was patchy immunostaining for S-100 protein, vimentin, protein gene product (PGP) 9.5 and neuron-specifi c enolase, and weak focal CD117 cytoplasmic immunoreactivity. The patient had no adjuvant chemotherapy; her postoperative recovery was uneventful, and she remains symptom-free, and without any sign of recurrence at 20 mo. To the best of our knowledge, this is only the third ever case of gastric ES.

关键词： Stomach extraskeletal Ewing's sarcoma

Gastrointestinal Stromal Tumor (GIST) with Chondroid-Myxoid-Chordoid Features Mimicking extraskeletal Myxoid Chondrosarcoma

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Open Journal of Pathology 2012年第3期2卷 85-89页

作者： Sonia Brar Christian Tvetenstrand Jagmohan Sidhu Department of Medicine UHS Hospitals Johnson City USA Department of Pathology and Laboratory Medicine UHS Hospitals Johnson City USA Department of Surgery UHS Hospitals Johnson City USA

Epithelioid gastrointesinal tumors (GISTs) are less likely to have c-kit gene mutations (and express CD117) than spindle cell GISTs. CD117 negative/c-kit negative GISTs can have platelet-derived growth factor alpha (PDGFRα) gene mutations, overexpress PDGFRα protein and respond to imatinib mesylate. Many cases of CD117-negative/CD117-weakly positive, c-kit mutation negative and PDGFRα mutation positive myxoid epithelioid GISTs and one case of CD117-positive GIST with chondro-myxoid features mimicking chondrosarcoma have been reported. We report a case of myxoid epithelioid GIST with predominance of chondroid and chordoid areas resembling an extraskeletal myxoid chondrosarcoma that was strongly positive for CD117, PDGFRα and DOG1 (Discovered on GIST 1) by immunohistochemistry, but lacked c-kit and PDGFRα gene mutations. It is possible that CD117 is strongly positive if a myxoid epithelioid GIST has chondroid/chordoid appearance, but a larger study is needed to confirm this association. CD117 expression in GISTs is important, because GISTs showing CD117 positivity respond to imatinib. No comment can be made about the prognostic significance of chondroid/chordoid appearance in the GISTs.

关键词： Gastrointestinal Stromal Tumor GIST PDGFRα CD117 c-kit extraskeletal Myxoid Chondrosarcoma

Huge peripheral primitive neuroectodermal tumor of the small bowel mesentery at nonage:A case report and review of the literature

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World Journal of Clinical Cases 2016年第9期4卷 306-309页

作者： Zhe Liu Yuan-Hong Xu Chun-Lin Ge Jin Long Rui-Xia Du Ke-Jian Guo Department of Pancreatic Surgery the First Hospital of China Medical University Department of Otorhinolaryngology Fengtian HospitalShenyang Medical University

extraskeletal Ewing's sarcoma/peripheral primitive neuroectodermal tumor(E-EWS/pP NET) is a rare aggressive malignant small round cell tumor. In this report, we present the case of a 15-year-old boy who suffered from acute abdominal pain accompanied by hematemesis and melena, and was eventually diagnosed with E-EWS/p PNET. To date, there have been only five reported cases of E-EWS/pP NET of the small bowel including the patient in this report. To the best of our knowledge, this is the first documentation of a pP NET of the small bowel mesentery at nonage. All these have made this report rare and significant.

关键词： extraskeletal Ewing’s sarcoma Peripheral primitive neuroectodermal tumor Nonage Small bowel mesentery Spontaneous rupture

Giant abdominal osteosarcoma causing intestinal obstruction treated with resection and adjuvant chemotherapy

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World Journal of Gastrointestinal Surgery 2017年第2期9卷 68-72页

作者： Alexandros Diamantis Grigorios Christodoulidis Dionysia Vasdeki Foteini Karasavvidou Evangelos Margonis Konstantinos Tepetes Depart-ment of General Surgery University Hospital of Larisa Division of Anatomic Pathology Univer-sity Hospital of Larisa

extraskeletal osteosarcoma(ESOS)is an uncommon tumor that accounts for 1% of all soft tissue sarcomas and 4% of all osteosarcomas. Its presentation may be atypical,while pain has been described as the most common symptom. Radiological findings include a large mass in the soft-tissues with massive calcifications,but no attachment to the adjacent bone or periosteum. We present the case of a 73-year-old gentle man who presented with a palpable,tender abdominal mass and symptoms of bowel obstruction. Computer tomography images revealed a large space-occupying heterogeneous,hyper dense soft tissue mass involving the small intestine. Explorative laparotomy revealed a large mass in the upper mesenteric root of the small intestine,measuring 22 cm × 12 cm × 10 cm in close proximity with the cecum,which was the cause of the bowel obstruction. Pathology confirmed the diagnosis of an ESOS. ESOS is an uncommon malignant soft tissue tumor with poor prognosis and a 5-year survival rate of less than 37%. Regional recurrence and distant metastasis to lungs,regional lymph nodes and liver can occur within the first three years of diagnosis in a high rate(45% and 65% respectively). Wide surgical resection of the mass followed by adjuvant chemotherapy or radiotherapy has been the treatment of choice.

关键词： Osteosarcoma Sarcoma extraskeletal Intestinal obstruction Abdominal mass Soft tissue

Two Cancers Arising from Different Mesenchymal Origins: An Unexpected Connection over Time and Space

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Case Reports in Clinical Medicine 2019年第5期8卷 99-104页

作者： Natascha Putri Sze Min Lek Nicholas Brian Shannon Joey Wee-Shan Tan Grace Hwei Ching Tan Claramae Shulyn Chia Melissa Ching Ching Teo Choon Hua Thng Timothy Kwang Yong Tay Chin-Ann Johnny Ong Tina Puay Theng Koh Division of Surgical Oncology National Cancer Centre Singapore Singapore City Singapore Division of Oncologic Imaging National Cancer Centre Singapore Singapore City Singapore Department of Anatomical Pathology Singapore General Hospital Singapore City Singapore

Sarcomas are rare tumours, accounting for 1% of all malignancies. They are histologically diverse, presenting with more than 50 different subtypes. Sarcoma can be broadly divided into two categories—soft tissue sarcoma and bone sarcoma. extraskeletal osteosarcoma is a unique subtype which is histologically similar to bone osteosarcoma but resides within soft tissue and has no attachments to bone. We present a rare case of a patient who initially presented with an extraskeletal osteosarcoma that was complicated by a chronic chest wall sinus and lymphedema of the left arm. He later developed enlarging left chest wall nodules at the same region that were proven to be dedifferentiated liposarcoma on biopsy 20 years later. We examine the occurrence of both extremely rare diseases of differing pathologies over the same site but separated by an extraordinarily long interval, and possible new associations to account for this phenomenon.

关键词： Sarcoma extraskeletal Osteosarcoma Dedifferentiated Liposarcoma Osteogenic Sarcoma

Primary Chondrosarcoma of the Mammary Gland of a Spayed American Akita Bitch: A Case Report

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Open Journal of Veterinary Medicine 2012年第2期2卷 81-83页

作者： Frank Herbert Comhaire Inge Matteeusen Hilde De Cock Dierenartsen Praktijk Healthy Paws De Pinte Belgium MedVet Inc. Antwerpen Belgium Private Consultant Sint Martens-Latem Belgium

An eleven-year-old spayed American Akita bitch rapidly developed a mammary tumour which was surgically removed. The histological examination revealed the tumour to be a sarcoma that presented positive immunohistochemical staining against vimentin and protein S 100. There was no staining against pan-actin. Based on the histological aspect and the pattern of immunohistochemical staining the diagnosis of primary extraskeletal chondrosarcoma of the mammary gland was considered most probable. Two months later the patient was euthanized with recurrent local tumour and metastases in the lungs.

关键词： Chondrosarcoma extraskeletal Akita Mammary Tumour

Primary chondrosarcoma of the liver:case report and literature review

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Journal of Medical Colleges of PLA(China) 2011年第3期26卷 128-133页

作者： Zhu Zhen Guo Jia Dong Hui Cong Wenming Department of Pathology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of Ultrasonography Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

We present a rare case of primary chondrosarcoma of the liver in a 57-year-old man with pre-existing hepatitis B virus-related chronic *** MRI scans showed a huge cystic-solid occupation of 18 cm×17 cm×11 cm in the right hepatic *** tumor was completely resected,and the histological findings identified low-grade cartilaginous component with typical ring-and-arc chondroid matrix ***,the neoplastic cells were positive for vimentin and S-100 *** patient received once postoperative adjuvant transcatheter arterial chemoembolization(TACE)at the 2nd month after discharge,and he is still alive for more than 13 months without recurrence and *** the best of our knowledge,this is the first case of primary chondrosarcoma of the liver.

关键词： Chondrosarcoma extraskeletal Primary Liver