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Giant abdominal osteosarcoma causing intestinal obstruction treated with resection and adjuvant chemotherapy

Giant abdominal osteosarcoma causing intestinal obstruction treated with resection and adjuvant chemotherapy

作     者:Alexandros Diamantis Grigorios Christodoulidis Dionysia Vasdeki Foteini Karasavvidou Evangelos Margonis Konstantinos Tepetes 

作者机构:Depart-ment of General SurgeryUniversity Hospital of Larisa Division of Anatomic Pathology Univer-sity Hospital of Larisa 

出 版 物:《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志(英文版)(电子版))

年 卷 期:2017年第9卷第2期

页      面:68-72页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主  题:Osteosarcoma Sarcoma Extraskeletal Intestinal obstruction Abdominal mass Soft tissue 

摘      要:Extraskeletal osteosarcoma(ESOS)is an uncommon tumor that accounts for 1% of all soft tissue sarcomas and 4% of all osteosarcomas. Its presentation may be atypical,while pain has been described as the most common symptom. Radiological findings include a large mass in the soft-tissues with massive calcifications,but no attachment to the adjacent bone or periosteum. We present the case of a 73-year-old gentle man who presented with a palpable,tender abdominal mass and symptoms of bowel obstruction. Computer tomography images revealed a large space-occupying heterogeneous,hyper dense soft tissue mass involving the small intestine. Explorative laparotomy revealed a large mass in the upper mesenteric root of the small intestine,measuring 22 cm × 12 cm × 10 cm in close proximity with the cecum,which was the cause of the bowel obstruction. Pathology confirmed the diagnosis of an ESOS. ESOS is an uncommon malignant soft tissue tumor with poor prognosis and a 5-year survival rate of less than 37%. Regional recurrence and distant metastasis to lungs,regional lymph nodes and liver can occur within the first three years of diagnosis in a high rate(45% and 65% respectively). Wide surgical resection of the mass followed by adjuvant chemotherapy or radiotherapy has been the treatment of choice.

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