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exosomal pd-l1: an effective liquid biopsy target to predict immunotherapy response

National Science Review 2019年第6期6卷 1103-1104页

作者： Yanling Song lingling Wu Chaoyong Yang Institute of Molecular Medicine Renji HospitalSchool of Medicine Shanghai Jiao Tong University MOE Key laboratory of Spectrochemical Analysis & Instrumentation Key Laboratory for Chemical Biology of Fujian Province State Key Laboratory of Physical Chemical of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University

Up-regulation of programmed deathligand 1(pd-l1) may allow cancer cells to evade the host immune system by recognizing the immune checkpoint programmed death-1(pd-1) on T cells to promote self-tolerance by suppressing T-cell inflammatory activity [1]. Blocking the interaction between pd-l1 and pd-1 has positive anti-tumor effects [2].

关键词： exosomal pd-l1 an effective liquid biopsy target to predict immunotherapy response

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The link between intracellular calcium signaling and exosomal pd-l1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： Md Rakibul Alam Md Mizanur Rahman Zhiguo li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(pd-l1)that binds with re-ceptor program death protein 1(pd-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking pd-1/pd-l1 *** notable treatment outcomes,some pa-tients show poor drug *** pd-l1 plays a vital role in lowering the treatment response,showing resistance to pd-1/pd-l1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal pd-l1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular pd-l1 ***,to enhance the pd-1/pd-l1 blockage therapy response,the reduction of exosomal pd-l1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of pd-l1-containing exosome levels that could reduce the anti-pd-1/pd-l1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells exosomal pd-l1 Exosomes biogenesis Immunosuppression Immunotherapy

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