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estrogen receptor a gene PvulI polymorphism and coronary artery disease： a meta-analysis of 21 studies

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第3期15卷 243-255页

作者： Jie DING Hui XU Xiang YIN Fu-rong ZHANG Xiao-ping PAN Yi-an GU Jun-zhu CHEN Xiao-gang GUO Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Xiuzhou District Gaozhao Street Community Health Service Center Jiaxing 314031 China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Columbia University Medical Center New York NY l0032 USA

The association between the estrogen receptor a gene （ESR1） Pvull polymorphism （c.454-397T〉C） and coronary artery disease （CAD） is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios （ORs） with 95% confidence intervals （CIs） were used to assess the relationship between Pvull polymorphism and CAD. The poly- morphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 Pvull polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 Pvull polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 Pvull polymorphism has an important role in CAD susceptibility.

关键词： estrogen receptor a gene Polymorphism Meta-analysis Coronary artery disease (CAD)

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Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women

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Acta Pharmacologica Sinica 2005年第7期26卷 860-864页

作者： Hong XU~(1,2) Ji-rong LONG~3 Miao-xin LI~1 Hong-wen DENG~(1,3) 1 Laboratory of Molecular and Statistical genetics,College of Life Sciences,Hu-nan Normal University,Changsha 410081,China 2 Department of Physiology,Jiangxi Medical College,Nanchang 330006,China 3 Osteoporosis Research Center and Department of Biomedical Sciences,Creighton University Medical Center,601 N 30th St,Suite 6787,Omaha,NE 68131,USA Laboratory of Molecular and Statistical genetics College of Life Sciences Hu-nan Normal University Changsha 410081 China

Aim:To evaluate whether estrogen receptor α(ER-α)and vitamin D receptor(VDR)genes are associated with the age at menarche in Chinese ***:A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII,XbaI,and VDR Apal loci using polymerase chain reaction(PCR)-restriction frag-ment length polymorphism(RFLP).Results:Neither the ER-α gene nor the VDRgene individually had significant effects on the age at menarche in our subjects(P>0.10).However,evidence of interaction effects between the two genes wereobserved:with the aa genotype at the VDR ApaI locus,subjects with haplotypePX at the ER-α gene had,on average,6 months later onset of menarche than thenon-carriers(P=0.01).Conclusion:We found that neither the ER-α gene or theVDR gene had a significant association with the age at menarche ***,potential interaction effects between the two genes were observed inChinese women.

关键词： menarche association haplotype estrogen receptor a gene vitamin D receptor gene

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