Estrogen receptor a gene PvulI polymorphism and coronary artery disease： a meta-analysis of 21 studies

作     者：Jie DING Hui XU Xiang YIN Fu-rong ZHANG Xiao-ping PAN Yi-an GU Jun-zhu CHEN Xiao-gang GUO 

作者机构：Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Xiuzhou District Gaozhao Street Community Health Service Center Jiaxing 314031 China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Columbia University Medical Center New York NY l0032 USA 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2014年第15卷第3期

页      面：243-255页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Project supported by the Zhejiang Provincial Natural Science Foundation of China (No. LY12H02006) and the Health Bureau of Zhcjiang Province (No. 2011RCB016)  China 

主　　题：Estrogen receptor a gene Polymorphism Meta-analysis Coronary artery disease (CAD) 

摘      要：The association between the estrogen receptor a gene （ESR1） Pvull polymorphism （c.454-397T〉C） and coronary artery disease （CAD） is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios （ORs） with 95% confidence intervals （CIs） were used to assess the relationship between Pvull polymorphism and CAD. The poly- morphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 Pvull polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 Pvull polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 Pvull polymorphism has an important role in CAD susceptibility.