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Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia

World Journal of Gastroenterology 2010年第27期16卷 3445-3449页

作者： Ying-Zhi Zhou Yu-Tao Diao Hao Li Hui-Qing Li Qing Ma Jia Cui School of Economics Shandong University 27# Shanda Nanlu Jinan 250100 Shandong Province China Department of Epidemiology and Health Statistics School of Public Health 44# Wenhuaxi Road Jinan 250012 China Tumor Center Qilu Hospital of Shandong University107# Wenhuaxi RoadJinan 250012Shandong ProvinceChina Department of Epidemiology Institute of Basic MedicineShandong Academy of Medical Sciences18877# Jingshi RoadJinan 250062Shandong ProvinceChina

AIM:To demonstrate the possible associations between genetic polymorphisms of aldehyde dehydrogenase-2(ALDH2) and esophageal squamous cell dysplasia(ESCD).METHODS:All participants came from an area of high incidence of esophageal cancer and underwent an endoscopic staining examination;biopsies were taken from a non-staining area of the mucosa and diagnosed by *** on the examinations,the subjects were divided into the control group with normal esophageal squamous epithelial cells and the ESCD ***2 genotypes of 396 cases were determined including 184 ESCD cases and 212 *** odds ratio(OR) and 95% confidence intervals(95% CI) were calculated by binary logistic regression ***:The distribution of ALDH2 genotypes showed significant differences between the two *** adjustment factors were gender and age in the logistic regression *** with 2*2/2*2 genotype,2*1/2*1 genotype was found to be a risk factor for ESCD,and the OR(95% CI) was 4.50(2.21-9.19).There were significant correlations between ALDH2 genotypes and alcohol drinking/smoking/history of esophageal ***:The ALDH2 polymorphism is significantly associated with ESCD.

关键词： Aldehyde dehydrogenase 2 Polymorphism Alcohol Smoking esophageal squamous cell dysplasia History of esophageal cancer

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Diagnosis and therapy of esophageal squamous cell dysplasia and early esophageal squamous cell cancer

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Gastroenterology Report 2017年第4期5卷 247-257,I0001页

作者： Charumathi Raghu Subramanian George Triadafilopoulos Internal Medicine Guthrie clinicSayrePAUSA and Division of Gastroenterology and Hepatology Stanford UniversityStanfordCAUSA

esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC)comprise the majority of esophageal cancers,and they differ from each other in several *** the incidence of EAC is increasing in the West,ESCC is still the predominant cancer type *** dysplasia is considered to be a premalignant lesion to ESCC;however,the exact probability and timeline of malignant transformation are not known,hence the lack of guidelines for management of such *** carries a poor prognosis if not detected early,so there has been a trend towards early detection and *** modalities include endoscopic ultrasound,white light endoscopy,non-endoscopic methods such as biomarkers,*** diagnosis can identify a subset of patients who could benefit from less invasive endoscopic eradication *** review aims to discuss the different modalities for diagnosis and treatment of early esophageal squamous lesions,including the newer endoscopic therapies,and comparison of different techniques.

关键词： esophageal squamous cell carcinoma esophageal squamous cell dysplasia endoscopic resection radiofrequency ablation

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Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program

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World Journal of Gastroenterology 2016年第39期22卷 8770-8778页

作者： Hao Zhang Hao Li Qing Ma Fang-Yan Yang Tao-Yu Diao Department of Gastroenterology The Third Hospital of JinanJinan 250132Shangdong ProvinceChina Tumor Center Qilu Hospital of Shandong UniversityJinan 250012Shangdong ProvinceChina Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021Shangdong ProvinceChina Department of Epidemiology and Biostatistics West China School of Public HealthSichuan UniversityChengdu 610041Sichuan ProvinceChina Institute of Basic Medicine Shandong Academy of Medical SciencesJinan 250062Shangdong ProvinceChina

AIM To determine the association of p53, carcinoembryonic antigen(CEA) and CA19-9 protein expression with esophageal *** An iodine staining endoscopic screening program of esophageal lesions was carried out in the high-incidence area of Feicheng County, China. Seventy-seven patients with basal cell hyperplasia(BCH), 247 with low-grade dysplasia(LGD), 51 with high-grade dysplasia(HGD), 134 with invasive cancer, and 80 normal controls diagnosed by mucous membrane biopsy pathology were enrolled. Immunohistochemical detection of p53, CEA and CA19-9 proteins was performed. In the ROCcurve analysis, the expression of a single biomarker and the expression of a combination of biomarkers were used to predict the risk of these four esophageal *** The positive rates of p53 protein expression in invasive cancer, HGD, LGD, BCH and the normal control groups were 53.0%, 52.9%, 35.6%, 27.3% and 20.0%, respectively; the positive rates of CA19-9 protein expression were 44.0%, 33.3%, 16.5%, 9.2% and 6.2%, respectively; the positive rates of CEA protein expression were 74.6%, 60.8%, 23.3%, 23.7% and 16.2%, respectively. The positive rates of the combined expression of the three biomarkers were 84.3%, 76.5%, 47.6%, 42.9% and 27.5%, respectively. In the receiver operating characteristic curves of the combination of the three biomarkers, the specificity was 88.8% for the normal controls, and the sensitivity was 58.2% for invasive cancer, 25.5% for HGD, 11.2% for LGD, and 6.5% for *** p53, CEA and CA19-9 protein expression was correlated with esophageal carcinogenesis, and testing for the combination of these biomarkers is useful for identifying high-risk patients with precancerous lesions.

关键词： esophageal squamous cell cancer esophageal squamous cell dysplasia p53 Carcinoembryonic antigen CA19-9 Immunohistochemistry Prediction

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