Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia

作     者：Ying-Zhi Zhou Yu-Tao Diao Hao Li Hui-Qing Li Qing Ma Jia Cui 

作者机构：School of Economics Shandong University 27# Shanda Nanlu Jinan 250100 Shandong Province China Department of Epidemiology and Health Statistics School of Public Health 44# Wenhuaxi Road Jinan 250012 China Tumor CenterQilu Hospital of Shandong University107# Wenhuaxi RoadJinan 250012Shandong ProvinceChina Department of EpidemiologyInstitute of Basic MedicineShandong Academy of Medical Sciences18877# Jingshi RoadJinan 250062Shandong ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第27期

页      面：3445-3449页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The Project of National Natural Science Foundation of China,No.30571601 the 2004 Key Special Project of Scientific and Technological Development in Shandong Province,China,No.2004GG1108039 the 2007 Special Foundation for Postdoctoral Innovation Subject in Shandong Province of China,No.200702034 

主　　题：Aldehyde dehydrogenase 2 Polymorphism Alcohol Smoking Esophageal squamous cell dysplasia History of esophageal cancer 

摘      要：AIM:To demonstrate the possible associations between genetic polymorphisms of aldehyde dehydrogenase-2(ALDH2) and esophageal squamous cell dysplasia(ESCD).METHODS:All participants came from an area of high incidence of esophageal cancer and underwent an endoscopic staining examination;biopsies were taken from a non-staining area of the mucosa and diagnosed by histopathology.Based on the examinations,the subjects were divided into the control group with normal esophageal squamous epithelial cells and the ESCD group.ALDH2 genotypes of 396 cases were determined including 184 ESCD cases and 212 controls.The odds ratio(OR) and 95% confidence intervals(95% CI) were calculated by binary logistic regression models.RESULTS:The distribution of ALDH2 genotypes showed significant differences between the two groups.The adjustment factors were gender and age in the logistic regression models.Compared with 2*2/2*2 genotype,2*1/2*1 genotype was found to be a risk factor for ESCD,and the OR(95% CI) was 4.50(2.21-9.19).There were significant correlations between ALDH2 genotypes and alcohol drinking/smoking/history of esophageal cancer.CONCLUSION:The ALDH2 polymorphism is significantly associated with ESCD.